Delta-He a new biomarker for a surgical clinic

Teryaeva NB, Gadzhieva OA, Nazarov VV, Bashiryan BA, Kadasheva AB, Cherekaev VA, Tlisova MN. Delta-He a new biomarker for a surgical clinic. Burdenko's Journal of Neurosurgery. 2022;86(4):60‑65. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20228604160

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

Close metadata

BACKGROUND

Delta-He the difference between hemoglobin content in reticulocytes and erytrocytes is a relatively new laboratory indicator that is easily measured in everyday practice. This parameter is directly related to iron bioavailability for hemoglobin synthesis and can reflect various conditions accompanied by cytokine expression including systemic inflammation.

OBJECTIVE

To analyze the prospects for practical application of hemoglobin delta in assessment of neurosurgical patients throughout in-hospital treatment.

MATERIAL AND METHODS

We analyzed complete blood counts (Sysmex XN-1000 analyzer) with optical determination of reticulocyte hemoglobin and automatic calculation of Delta-He in 82 neurosurgical patients. Exclusion criteria were severe decompensated comorbidities, exacerbation of chronic infectious processes, cancer of other organs. Blood sampling for analysis of delta-hemoglobin was carried out before all diagnostic and therapeutic measures. Reference interval is indicated by the analyzer manufacturer as 1.7-4.4 pg.

RESULTS

Delta-He values at admission ranged from -1.8 to 6.1 pg. There was a consistent decrease of these values throughout 3-4 postoperative days. Then, the values could increase or continued to decrease. Increment of the index was noted in 76 patients (92.7%). Such dynamics was observed in case of uncomplicated postoperative period. Further decrease of Delta-He was observed in 6 patients (7.3%). These ones were characterized by a longer recovery after surgery, and the events required additional medical or surgical correction were recorded. Negative dynamics of Delta-He values could precede clinical manifestations of certain complication. Clarification of diagnosis and correction of therapy were accompanied by gradual increase of Delta-He values.

CONCLUSION

Estimation of Delta-He values over time can be used for monitoring of patients and effectiveness of therapy. From a practical point of view, it is important that examination can be performed at any time of the day.

Keywords:

neurosurgery

biomarkers

hemoglobin delta

hepcidin

systemic inflammation

complications

Authors:

Teryaeva N.B.

Burdenko Neurosurgical Center

ORCID: 0000-0001-8535-8535

Gadzhieva O.A.

Burdenko Neurosurgery Center

ORCID: 0000-0002-9850-050X

Nazarov V.V.

Burdenko Neurosurgical Center

ORCID: 0000-0002-5938-6548

Bashiryan B.A.

Burdenko Neurosurgical Center

ORCID: 0000-0002-5559-2678

Kadasheva A.B.

Burdenko Neurosurgical Center

ORCID: 0000-0003-1416-6936

Cherekaev V.A.

Burdenko Neurosurgical Center

ORCID: 0000-0001-6881-7082

Tlisova M.N.

Burdenko Neurosurgical Center

ORCID: 0000-0003-3868-7664

Received:

11.01.2022

Accepted:

31.03.2022

Close metadata

References:

Danielson K, Beshara S, Qureshi A, Heimbürger O, Lindholm B, Hansson M, Hylander B, Germanis G, Stenvinkel P, Barany P. Delta-He: a novel marker of inflammation predicting mortality and ESA response in peritoneal dialysis patients. Clinical Kidney Journal. 2014;7(3):275-281. https://doi.org/10.1093/ckj/sfu038
Weimann A, Cremer M, Hernaiz-Driever P, Zimmermann M. Delta-He, Ret-He and a New Diagnostic Plot for Differential Diagnosis and Therapy Monitoring of Patients Suffering from Various Disease-Specific Types of Anemia. Clinical Laboratory. 2016;62(4):667-677. https://doi.org/10.7754/clin.lab.2015.150830
Schoorl M, Schoorl M, Linssen J, Villanueva MM, NoGuera JAV, Martinez PH, Bartels PCM. Efficacy of Advanced Discriminating Algorithms for Screening on Iron-Deficiency Anemia and β-Thalassemia Trait: A Multicenter Evaluation. American Journal of Clinical Pathology. 2012;138(2):300-304. https://doi.org/10.1309/AJCP20UTTCAYKUDX
Schoorl M, Schoorl M, van Pelt J, Bartels PCM. Application of innovative hemocytometric parameters and algorithms for improvement of microcytic anemia discrimination. Hematology Reports. 2015;7(2):5843. https://doi.org/10.4081/hr.2015.5843
Henriot I, Launay E, Boubaya M, Cremet L, Illiaquer M, Caillon H, Desjonqueres A, Gillet B, Bene MC, Eveillard M. New parameters on the hematology analyzer XN-10 (SysmexTM) allow to distinguish childhood bacterial and viral infections. International Journal of Laboratory Hematology. 2017;39(1):14-20. https://doi.org/10.1111/ijlh.12562
Pagani A, Nai1 A, Silvestri L, Camaschella C. Hepcidin and Anemia: A Tight Relationship. Frontiers in Physiology. 2019;10:1294. https://doi.org/10.3389/fphys.2019.01294
Petrova J, Manolov V, Vasilev V, Tzatchev K, Marinov B. Ischemic stroke, inflammation, iron overload — Connection to a hepcidin. International Journal of Stroke. 2016;11(1):16-17. https://doi.org/10.1177/1747493015607509
de Mast Q, van Dongen-Lases EC, Swinkels DW, Nieman A-E, Meta Roestenberg M, Druilhe P, Arens ThA, Luty AJ, Hermsen CC, Sauerwein RW, van der Ven AJ. Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection. British Journal of Haematology. 2009;145(5):657-664. https://doi.org/10.1111/j.1365-2141.2009.07664.x/
Epstein J, Breslow MJ. The stress response of critical illness. Critical Care Clinics. 1999;15(1):17-v. https://doi.org/10.1016/s0749-0704(05)70037-3
Desborough JP. Stress response to trauma and surgery. British Journal of Anaesthesia. 2000;85(1):109-117. https://doi.org/10.1093/bja/85.1.109
Burton D, Nicholson G, Hall G. Endocrine and metabolic response to surgery. Critical Care & Pain. 2004;4(5):144-147. https://doi.org/10.1093/bjaceaccp/mkh046
Bokerija LA, Teryaeva NB, Egorova MO, Goluhova EZ, Zhvanija TO. Biochemical parameters of blood of the postoperative period in closed heart operations. Byulleten’ NTSSSKH im. A.N. Bakuleva RAMN Serdechno-sosudistyye zabolevaniya. 2003;4(7):47-52. (In Russ).
Teryaeva NB, Belyaev AYu, Usachev DYu, Fadeeva LM, Lukshin VA. Dehydroepiandrosterone-sulfate as a stress response effector. Rossijskij fiziologicheskij zhurnal imeni I.M. Sechenova. 2017;103(1):98-106. (In Russ).
Черекаев В.А., Кадашева А.Б., Гольбин Б.А., Белов А.И., Козлов А.В., Решетов И.В., Spallone A., Ласунин Н.В., Спирин Д.С. Хирургия опухолей основания черепа, распространяющихся в глазницу, околоносовые пазухи, полость носа, крылонебную и подвисочную ямки: принципы лечения отдельных видов новообразований. Вопросы нейрохирургии имени Н.Н. Бурденко. 2014;78(2):12-21.
Cherekaev VA, Kadasheva AB, Gol’bin BA, Belov AI, Kozlov AV, Reshetov IV, Spallone A, Lasunin NV, Spirin DS. Surgery of skull base tumors extending into the orbit, paranasal sinuses, nasal cavity, pterygopalatine and infratemporal fossas: treatment principles in certain types of tumors. Voprosy Neirokhirurgii imeni N.N. Burdenko. 2014;78(2):12-21. (In Russ.).
Nazarov VV, Cherekaev V., Kobyakov GL, Reshetov IV, Spirin DS, Kozlov VA, Belov AI, Kadasheva AB. Surgical aspects of the treatment of malignant tumors of the base of the skull. Neirokhirurgiya. 2016;1:6. (In Russ.).
Kadasheva A. Review of «Life Quality of Patients With Benign Tumors of the Anterior and Middle Part of the Skull Base After Surgery and During Follow-Up [in Russian]» by Kadasheva AB, Cherekaev VA, Shifrin MA, Kozlov AV, Golbin DA, Tsukanova TV, Galkin MV, Belov AI, Radchenkov NS in Zh Vopr Neirokhir Im NN Burdenko;79: 44-54, 2015. Journal of Craniofacial Surgery. 2016;27(7):1912-1913.