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Gorozhanin A.V.

Botkin Moscow City Clinical Hospital

Kuzin A.V.

Russian Medical Academy of Continuous Professional Education;
A.V. Nassonova Research Institute of Rheumatology

Bludov A.B.

Blokhin Russian Cancer Research Center

Radenska-Lopovok S.G.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Russian Medical Academy of Continuous Professional Education

Smirnov A.V.

Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies

Kuzin D.A.

Sechenov First Moscow State Medical University

Krylov A.S.

Blokhin Russian Cancer Research Center

Severe spine lesion following alkaptonuria. Case report

Authors:

Gorozhanin A.V., Kuzin A.V., Bludov A.B., Radenska-Lopovok S.G., Smirnov A.V., Kuzin D.A., Krylov A.S.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(5): 104‑109

DOI: 10.17116/neiro202185051104

Read: 4158 times

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Table of contents

SEVERE SPINE LESION FOLLOWING ALKAPTONURIA. CASE REPORT
SEVERE SPINE LESION FOLLOWING ALKAPTONURIA. CASE REPORT

To cite this article:

Gorozhanin AV, Kuzin AV, Bludov AB, Radenska-Lopovok SG, Smirnov AV, Kuzin DA, Krylov AS. Severe spine lesion following alkaptonuria. Case report. Burdenko's Journal of Neurosurgery. 2021;85(5):104‑109. (In Russ., In Engl.)
https://doi.org/10.17116/neiro202185051104

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Alkaptonuria is a rare autosomal recessive disease. In these patients, melanin-like compounds as the final products of impaired metabolism of homogentisic acid are deposited mainly in connective tissue, including cartilage tissue of intervertebral discs. Similar to other degenerative spine diseases, lumbar segment is often damaged. The authors report a 67-year-old patient with alkaptonuria. Compression of cauda equina by damaged cartilage masses of intervertebral discs and spine ligaments with deposits of ochronotic pigment is described. Previously diagnosed alkaptonuria in this patient was confirmed by surgical findings (black pigmentation) and histological data.

Keywords:

alkaptonuria
ochronosis
back pain

Authors:

Gorozhanin A.V.

Botkin Moscow City Clinical Hospital

Kuzin A.V.

Russian Medical Academy of Continuous Professional Education;
A.V. Nassonova Research Institute of Rheumatology

Bludov A.B.

Blokhin Russian Cancer Research Center

Radenska-Lopovok S.G.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Russian Medical Academy of Continuous Professional Education

Smirnov A.V.

Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies

Kuzin D.A.

Sechenov First Moscow State Medical University

Krylov A.S.

Blokhin Russian Cancer Research Center

Received:

14.01.2021

Accepted:

05.08.2021

Close metadata

References:

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