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Kriukova K.K.

Sechenov First Moscow State Medical University

Aleksandrova E.V.

Burdenko Neurosurgical Center

Voskresenskaya O.N.

Sechenov First Moscow State Medical University

Bragin A.G.

University of California of the Los Angeles

Podlepich V.V.

Burdenko Neurosurgical Center

Sokolova E.Yu.

Burdenko Neurosurgical Center

Lapteva K.N.

Burdenko Neurosurgical Center

Troshina E.M.

Burdenko Neurosurgical Center

Oshorov A.V.

Burdenko Neurosurgical Center

Potapov A.A.

Burdenko Neurosurgical Center

Early predictive biomarkers of posttraumatic epilepsy

Authors:

Kriukova K.K., Aleksandrova E.V., Voskresenskaya O.N., Bragin A.G., Podlepich V.V., Sokolova E.Yu., Lapteva K.N., Troshina E.M., Oshorov A.V., Potapov A.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(5): 110‑115

DOI: 10.17116/neiro202185051110

Read: 3461 times

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Table of contents

EARLY PREDICTIVE BIOMARKERS OF POSTTRAUMATIC EPILEPSY
EARLY PREDICTIVE BIOMARKERS OF POSTTRAUMATIC EPILEPSY

To cite this article:

Kriukova KK, Aleksandrova EV, Voskresenskaya ON, et al. Early predictive biomarkers of posttraumatic epilepsy. Burdenko's Journal of Neurosurgery. 2021;85(5):110‑115. (In Russ., In Engl.)
https://doi.org/10.17116/neiro202185051110

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Traumatic brain injury (TBI) affects about 50 million people in the world every year. Posttraumatic epilepsy (PTE) is a significant complication of TBI of any severity. PTE occurs in 20% of patients with TBI. Treatment of patients with PTE is particularly difficult due to obvious tendency towards drug resistance. Currently, there are no validated predictive biomarkers for PTE. Development of a system of validated predictive biomarkers would improve PTE prediction quality and therapeutic approach for these patients. This review is devoted to the current data on the most perspective predictive biomarkers of PTE for clinical practice.

Keywords:

post-traumatic seizures
cortical atrophy
pathological high-frequency oscillations
repetitive high-frequency oscillations and spikes
molecular genetic biomarkers
single nucleotide polymorphisms
glutamic acid decarboxylase gene
adenosine A1 receptor gene
neuronal glutamate transporters

Authors:

Kriukova K.K.

Sechenov First Moscow State Medical University

Aleksandrova E.V.

Burdenko Neurosurgical Center

Voskresenskaya O.N.

Sechenov First Moscow State Medical University

Bragin A.G.

University of California of the Los Angeles

Podlepich V.V.

Burdenko Neurosurgical Center

Sokolova E.Yu.

Burdenko Neurosurgical Center

Lapteva K.N.

Burdenko Neurosurgical Center

Troshina E.M.

Burdenko Neurosurgical Center

Oshorov A.V.

Burdenko Neurosurgical Center

Potapov A.A.

Burdenko Neurosurgical Center

Received:

23.01.2021

Accepted:

05.08.2021

Conflict of Interest :

The reported study was funded by RFBR according to the research project No. 20-315-90102.

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