The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Korolishin V.A.

Burdenko Neurosurgery Center

Stepanov I.A.

Irkutsk State Medical University

beloborodov V.A.

Irkutsk State Medical University

Brinyuk E.S.

Burdenko Neurosurgical Center

Konovalov N.A.

Burdenko Neurosurgical Center

Effect of renin-angiotensin-aldosterone system inhibitors on functional activity of the spinal cord and nerve roots in patients with degenerative lumbar spine diseases

Authors:

Korolishin V.A., Stepanov I.A., beloborodov V.A., Brinyuk E.S., Konovalov N.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(5): 41‑45

DOI: 10.17116/neiro20218505141

Read: 3333 times

Download PDF (RU)
Download PDF
Contact the author
Table of contents

EFFECT OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INHIBITORS ON FUNCTIONAL ACTIVITY OF THE SPINAL CORD AND NERVE ROOTS IN PATIENTS WITH DEGENERATIVE LUMBAR SPINE DISEASES
EFFECT OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INHIBITORS ON FUNCTIONAL ACTIVITY OF THE SPINAL CORD AND NERVE ROOTS IN PATIENTS WITH DEGENERATIVE LUMBAR SPINE DISEASES

To cite this article:

Korolishin VA, Stepanov IA, beloborodov VA, Brinyuk ES, Konovalov NA. Effect of renin-angiotensin-aldosterone system inhibitors on functional activity of the spinal cord and nerve roots in patients with degenerative lumbar spine diseases. Burdenko's Journal of Neurosurgery. 2021;85(5):41‑45. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20218505141

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Complications of gunshot wounds and blunt inju­ries of the spine and spinal cord in early period. Burdenko's Journal of Neurosurgery. 2025;(4):30-38
Postoperative pain as a cause of hype­rtension progression in women with preeclampsia after cesa­rean section. Russian Journal of Pain. 2025;(2):83-90
Prediction of restoration of functional acti­vity of pare­tic limbs in patients who have suffered an ischemic stroke. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(3):31-40
Analysis of the causes of late diagnosis of vascular myelopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):117-123
Abstract:

High neuroprotective activity of renin-angiotensin-aldosterone system (RAAS) inhibitors in patients with vascular diseases of the brain and spinal cord has been confirmed.

OBJECTIVE

To evaluate the effect of renin-angiotensin-aldosterone system inhibitors on functional activity of the spinal cord and nerve roots in patients with degenerative lumbar spine diseases.

MATERIAL AND METHODS

A retrospective observational cohort study was performed. We evaluated clinical and radiological parameters (gender, age of patients, type of antihypertensive drug, concomitant diseases, ODI (6) and SF-36 (7) scores of patient quality of life), functional recovery, increase of signal intensity and its area in T2WIs, localization and maximum spinal canal stenosis, as well as maximum spinal cord and nerve root compression.

RESULTS

The study included 117 medical records of respondents (88 men and 29 women aged 56.9±13.2 years) who underwent lumbar spine surgery for degenerative diseases. Arterial hypertension was verified in 68 (58.1%) patients, diabetes mellitus in 22 (18.8%) respondents. Age (p=0.002), diabetes mellitus (p=0.007), arterial hypertension (p=0.015) and antihypertensive therapy (p=0.023) were significantly associated with worse clinical and neurological status of patients. Binary logistic regression model demonstrated that only arterial hypertension was significantly associated with low preoperative quality of life (p=0.002).

CONCLUSION

Intake of AT II-1 receptor blockers and angiotensin converting enzyme inhibitors for arterial hypertension is a significant predictor of decrease in signal intensity of the spinal cord and its roots according to T2WIs.

Keywords:

renin-angiotensin-aldosterone system
angiotensin II
angiotensin II-1 receptor blockers
angiotensin converting enzyme inhibitors
lumbar spine
degenerative diseases
spinal cord
spinal cord roots
functional activity

Authors:

Korolishin V.A.

Burdenko Neurosurgery Center

Stepanov I.A.

Irkutsk State Medical University

beloborodov V.A.

Irkutsk State Medical University

Brinyuk E.S.

Burdenko Neurosurgical Center

Konovalov N.A.

Burdenko Neurosurgical Center

Received:

22.03.2021

Accepted:

05.08.2021

Close metadata

References:

  1. Prasad GL, Menon GR. Simple Cost-Effective Surgeries for Degenerative Lumbar Spine Disease. World Neurosurgery. 2017;98:861.  https://doi.org/10.1016/j.wneu.2016.08.076
  2. Graham P. Lumbar Degenerative Disease with Intervertebral Disk Herniation. Orthopedic Nursing. 2018;37(1):68-69.  https://doi.org/10.1097/NOR.0000000000000427
  3. Wang JC, Dailey AT, Mummaneni PV, Ghogawala Z, Resnick DK, Watters WC, Groff MW, Choudhri TF, Eck JC, Sharan A, Dhall SS, Kaiser MG. Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 8: lumbar fusion for disc herniation and radiculopathy. Journal of Neurosurgery. Spine. 2014;21(1):48-53.  https://doi.org/10.3171/2014.4.SPINE14271
  4. Keorochana G, Setrkraising K, Woratanarat P, Arirachakaran A, Kongtharvonskul J. Clinical outcomes after minimally invasive transforaminal lumbar interbody fusion and lateral lumbar interbody fusion for treatment of degenerative lumbar disease: a systematic review and meta-analysis. Neurosurgical Review. 2018;41(3):755-770.  https://doi.org/10.1007/s10143-016-0806-8
  5. Jensen MC, Kelly AP, Brant-Zawadzki MN. MRI of degenerative disease of the lumbar spine. Magnetic Resonance Quarterly. 1994;10(3):173-190. 
  6. Karsy M, Bisson EF. Surgical Versus Nonsurgical Treatment of Lumbar Spondylolisthesis. Neurosurgery Clinics of North America. 2019;30(3):333-340.  https://doi.org/10.1016/j.nec.2019.02.007
  7. Sandrow-Feinberg HR, Houlé JD. Exercise after spinal cord injury as an agent for neuroprotection, regeneration and rehabilitation. Brain Research. 2015;1619:12-21.  https://doi.org/10.1016/j.brainres.2015.03.052
  8. Sulejczak D, Taraszewska A, Chrapusta SJ, Dziewulska D, Nakielski P, Rafałowska J. Nanofiber mat spinal cord dressing-released glutamate impairs blood-spinal cord barrier. Folia Neuropathologica. 2016;54(4):392-404.  https://doi.org/10.5114/fn.2016.64818
  9. Nishimura Y, Ito T, Saavedra JM. Angiotensin II AT(1) blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats. Stroke. 2000;31(10):2478-2486. https://doi.org/10.1161/01.str.31.10.2478
  10. Güler A, Sahin MA, Ucak A, Onan B, Inan K, Oztaş E, Arslan S, Uysal B, Demirkiliç U, Tatar H. Protective effects of angiotensin II type-1 receptor blockade with olmesartan on spinal cord ischemia-reperfusion injury: an experimental study on rats. Annals of Vascular Surgery. 2010;24(6):801-808.  https://doi.org/10.1016/j.avsg.2010.03.023
  11. Lin CM, Tsai JT, Chang CK, Cheng JT, Lin JW. Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Drug Design, Development and Therapy. 2015;9:4709-4717. https://doi.org/10.2147/DDDT.S86616
  12. Kobalava ZhD, Konradi AO, Nedogoda SV, Arutyunov GP, Baranova EI, Barbarash OL, Villeval’de SV, Galyavich AS, Glezer MG, Drapkina OM, Kotovskaya YuV, Libis RA, Lopatin YuM, Nedoshivin AO, Ostroumova OD, Ratova LG, Tkacheva ON, Chazova IE, Chesnikova AI, Chumakova GA. Memorandum of experts of the Russian Society of Cardiology on the recommendations of the European Society of Cardiology/The European Society for Arterial Hypertension for the treatment of arterial hypertension in 2018. Rossijskij kardiologicheskij zhurnal. 2018;23(12):131-142. (In Russ.). https://doi.org/10.15829/1560-4071-2018-12-131-142
  13. von Elm E, Altman DG, Egger M, Stuart JP, Peter CG, Jan PV, STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies. International Journal of Surgery. 2014;12(12):1495-1499. https://doi.org/10.1016/j.ijsu.2014.07.013
  14. Skierka AS, Michels KB. Ethical principles and placebo-controlled trials — interpretation and implementation of the Declaration of Helsinki’s placebo paragraph in medical research. BMC Medical Ethics. 2018;19(1):24.  https://doi.org/10.1186/s12910-018-0262-9
  15. Belousov YuB. Klinicheskaya farmakologiya: nacional’noe rukovodstvo. Pod red. Belousova Yu.B., Kukesa V.G., Lepahina V.K., Petrova V.I. M.: GEOTAR-Media; 2014. (In Russ.).
  16. Peart WS. Renin-Angiotensin system. Quarterly Journal of Experimental Physiology. 1982;67(3):401-406.  https://doi.org/10.1113/expphysiol.1982.sp002655
  17. Navar LG, Nishiyama A. Intrarenal formation of angiotensin II. Contributions to Nephrology. 2001;135:1-15.  https://doi.org/10.1159/000060154
  18. Volicer L. Angiotensin. Ceskoslovenska Farmacie. 1965;14(8):431-437. 
  19. von Bohlen und Halbach O. Angiotensin IV in the central nervous system. Cell and Tissue Research. 2003;311(1):1-9.  https://doi.org/10.1007/s00441-002-0655-3
  20. Ganten D, Speck G. The brain renin-angiotensin system: a model for the synthesis of peptides in the brain. Biochemical Pharmacology. 1978;27(20):2379-2389. https://doi.org/10.1016/0006-2952(78)90348-9
  21. Huber G, Schuster F, Raasch W. Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases. Pharmacological Research. 2017;125(Pt A):729-730.  https://doi.org/10.1016/j.phrs.2017.06.016
  22. Farag E, Sessler DI, Ebrahim Z, Kurz A, Morgan J, Ahuja S, Maheshwari K, John Doyle D. The renin angiotensin system and the brain: New developments. Journal of Clinical Neuroscience. 2017;46:1-8.  https://doi.org/10.1016/j.jocn.2017.08.055
  23. Villapol S, Saavedra JM. Neuroprotective effects of angiotensin receptor blockers. American Journal of Hypertension. 2015;28(3):289-299.  https://doi.org/10.1093/ajh/hpu197
  24. Mehalic TF, Pezzuti RT, Applebaum BI. Magnetic resonance imaging and cervical spondylotic myelopathy. Neurosurgery. 1990;26(2):217-227.  https://doi.org/10.1097/00006123-199002000-00006
  25. Karadimas SK, Moon ES, Yu WR, Satkunendrarajah K, Kallitsis JK, Gatzounis G, Fehlings MG. A novel experimental model of cervical spondylotic myelopathy (CSM) to facilitate translational research. Neurobiology of Disease. 2013;54:43-58.  https://doi.org/10.1016/j.nbd.2013.02.013
  26. Karadimas SK, Klironomos G, Papachristou DJ, Papanikolaou S, Papadaki E, Gatzounis G. Immunohistochemical profile of NF-κB/p50, NF-κB/p65, MMP-9, MMP-2, and u-PA in experimental cervical spondylotic myelopathy. Spine. 2013;38(1):4-10.  https://doi.org/10.1097/BRS.0b013e318261ea6f
  27. Perdomo-Pantoja A, Chara A, Kalb S, Casaos J, Ahmed AK, Pennington Z, Cottrill E, Shah S, Jiang B, Manbachi A, Zygourakis C, Witham TF, Theodore N. The effect of renin-angiotensin system blockers on spinal cord dysfunction and imaging features of spinal cord compression in patients with symptomatic cervical spondylosis. The Spine Journal. 2020;20(4):519-529.  https://doi.org/10.1016/j.spinee.2019.12.002
  28. Fleegal-DeMotta MA, Doghu S, Banks WA. Angiotensin II modulates BBB permeability via activation of the AT(1) receptor in brain endothelial cells. Journal of Cerebral Blood Flow and Metabolism. 2009;29(3):640-647.  https://doi.org/10.1038/jcbfm.2008.158
  29. Sano H, Hosokawa K, Kidoya H, Takakura N. Negative regulation of VEGF-induced vascular leakage by blockade of angiotensin II type 1 receptor. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26(12):2673-2680. https://doi.org/10.1161/01.ATV.0000245821.77155.c3
  30. Lucius R, Gallinat S, Rosenstiel P, Herdegen T, Sievers J, Unger T. The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats. The Journal of Experimental Medicine. 1998;188(4):661-670.  https://doi.org/10.1084/jem.188.4.661
  31. Reinecke K, Lucius R, Reinecke A, Rickert U, Herdegen T, Unger T. Angiotensin II accelerates functional recovery in the rat sciatic nerve in vivo: role of the AT2 receptor and the transcription factor NF-kappaB. FASEB Journal. 2003;17(14):2094-2096. https://doi.org/10.1096/fj.02-1193fje
  32. Li ZQ, Zhao YP, Jia WY, Wang X, Chen B, Shahbaz M, Nie L, Cheng L. Surgical Treatment of Cervical Spondylotic Myelopathy Associated Hypertension — A Retrospective Study of 309 Patients. PLoS One. 2015;10(7):e0133828. https://doi.org/10.1371/journal.pone.0133828
  33. Peng B, Pang X, Li D, Yang H. Cervical spondylosis and hypertension: a clinical study of 2 cases. Medicine. 2015;94(10):e618. https://doi.org/10.1097/MD.0000000000000618
  34. Itoki K, Kurokawa R, Shingo T, Kim P. Effect of Myoarchitectonic Spinolaminoplasty on Concurrent Hypertension in Patients with Cervical Spondylotic Myelopathy. Neurospine. 2018;15(1):77-85.  https://doi.org/10.14245/ns.1836020.010
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.