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Astaf'eva L.I.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Zhukov O.B.

Peoples’ Friendship University of Russia, Moscow, Russia;
European Medical Center, Moscow, Russia

Kadashev B.A.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Klochkova I.S.

Burdenko Neurosurgical Institute, Moscow, Russian Federation

Kobiakov G.L.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Poddubskiy A.A.

Burdenko Neurosurgical Institute, Moscow, Russia

Kalinin P.L.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Reproductive disorders and preservation of fertility in males with benign and malignant brain tumors

Authors:

Astaf'eva L.I., Zhukov O.B., Kadashev B.A., Klochkova I.S., Kobiakov G.L., Poddubskiy A.A., Kalinin P.L.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2019;83(2): 59‑65

DOI: 10.17116/neiro20198302159

Read: 3997 times

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Table of contents

REPRODUCTIVE DISORDERS AND PRESERVATION OF FERTILITY IN MALES WITH BENIGN AND MALIGNANT BRAIN TUMORS
REPRODUCTIVE DISORDERS AND PRESERVATION OF FERTILITY IN MALES WITH BENIGN AND MALIGNANT BRAIN TUMORS

To cite this article:

Astaf'eva LI, Zhukov OB, Kadashev BA, Klochkova IS, Kobiakov GL, Poddubskiy AA, Kalinin PL. Reproductive disorders and preservation of fertility in males with benign and malignant brain tumors. Burdenko's Journal of Neurosurgery. 2019;83(2):59‑65. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20198302159

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Brain tumors rank third in the incidence rate among cancer nosologies. However, improvement of neurosurgical treatment methods and the use of modern regimens of chemotherapy and radiotherapy have increased survival of patients with benign and malignant brain tumors. A significant proportion of patients with brain tumors are young people in the reproductive age who are interested in maintaining their fertility. Surgical removal of tumors, mainly in the hypothalamo-pituitary area as well as the use of chemotherapy and radiotherapy for malignant brain tumors of any localization may be complicated by hypogonadism and infertility. At present, a simple and reliable method of preserving male fertility is sperm cryopreservation. Neurosurgeons as well as oncologists and radiologists should inform patients with brain tumors about a potential risk of hypogonadism and infertility after treatment and about opportunities of sperm cryopreservation, which increases the chances of having future genetic progeny.

Keywords:

hypogonadism
male infertility
brain tumors
hypothalamo-pituitary tumors
spermatozoa cryopreservation

Authors:

Astaf'eva L.I.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Zhukov O.B.

Peoples’ Friendship University of Russia, Moscow, Russia;
European Medical Center, Moscow, Russia

Kadashev B.A.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Klochkova I.S.

Burdenko Neurosurgical Institute, Moscow, Russian Federation

Kobiakov G.L.

GBU NII neĭrokhirurgii im. N.N. Burdenko

Poddubskiy A.A.

Burdenko Neurosurgical Institute, Moscow, Russia

Kalinin P.L.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Close metadata

References:

  1. Ostrom QT, Gittleman H, Xu J, Kromer C, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS.CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2009—2013. Neuro Oncol. 2016 Oct 1;18(suppl_5):v1-v75. https://doi.org/10.1093/neuonc/now207
  2. Lambertini M, Del Mastro L, Pescio MC, Andersen CY, Azim HA Jr, Peccatori FA, Costa M, Revelli A, Salvagno F, Gennari A, Ubaldi FM, La Sala GB, De Stefano C, Wallace WH, Partridge AH, Anserini P. Cancer and fertility preservation: international recommendations from an expert meeting. BMC Med. 2016 Jan 4;14:1. https://doi.org/10.1186/s12916-015-0545-7
  3. Horne G, Atkinson AD, Pease EH, Logue JP, Brison DR, Lieberman BA. Live birth with sperm cryopreserved for 21 years prior to cancer treatment: Case report. Hum Reprod. 2004 Apr 22;19(6):1448-1449. https://doi.org/10.1093/humrep/deh249 PMID: 15163644
  4. Feldschuh J, Brassel J, Durso N, Levine A. Successful sperm storage for 28 years. Fertil Steril. 2005 Oct;84(4):1017.e3-1017.e4. https://doi.org/10.1016/j.fertnstert.2005.05.015 PMID: 16213859
  5. Ministerstvo zdravookhraneniya Rossiiskoi Federatsii. Prikaz Minzdrava Rossii №107n on 30.08.12 № 107n (red. on 11.06.15) «O poryadke ispol’zovaniya vspomogatel’nykh reproduktivnykh tekhnologii, protivopokazaniyakh i ogranicheniyakh k ikh primeneniyu». URL: http://www.consultant. ru/document/cons_doc_LAW_142595/
  6. Bystrova OV, Kalugina AS, Tsybatova EV, Tapil’skaya NI, Dinikina YuV, Lisyanskaya AS, Manikhas GM. Sposoby vosstanovleniya fertil’nosti u onkologicheskikh bol’nykh. Prakticheskaya onkologiya. 2009;10:4(40):245-253. (In Russ.)
  7. Makarova NP, Romanov AYu, Dus TA, Kalinina EA. Possibilities and problems of clinical embryology in IVF-patients with oncological diseases. Prakticheskaya onkologiya. 2017;18(3):275-284. (In Russ.)
  8. Sokhranenie fertil’nosti muzhchin. Pod red. Zhukova OB. M.: Spetsial’noe izdatel’stvo meditsinskikh knig. 2017. (In Russ.)
  9. Dedov I, Rozhivanov R, Rozhinskaya L, Vorontsov A, Kurbatov D. Sexual function in men with functioning and nonfunctioning pituitary adenomas. Vrach. 2011;7:90-92. (In Russ.)
  10. Cury ML, Fernandes JC, Machado HR, Elias LL, Moreira AC, Castro M. Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome. Arq Bras Endocrinol Metabol. 2009;53(1):31-39.
  11. Ferrante E, Ferraroni M, Castrignanò T, Menicatti L, Anagni M, Reimondo G, Del Monte P, Bernasconi D, Loli P, Faustini-Fustini M, Borretta G, Terzolo M, Losa M, Morabito A, Spada A, Beck-Peccoz P, Lania AG. Non- functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors. Eur J Endocrinol. 2006;155(6):823-829. https://doi.org/10.1530/eje.1.02298
  12. Giniyatullina EN, Dzeranova LK, Rozhinskaya LYa, Grigor’ev AYu. Reproduktivnye narusheniya pri giperprolaktinemii opukholevogo geneza u muzhchin (klinicheskie sluchai). Vestnik reprod. zdorov’ya. 2008;2:59-63. (In Russ.)
  13. Astaf’eva LI, Kadashev BA, Kalinin PL, Kutin MA, Shkarubo AN, Fomichev DV, Faĭzullaev RB, Alekseev SN, Sidneva YuG, Tenedieva VD, Tropinskaya OF. Clinical presentation, diagnostics and results of primary conservative treatment of large and giant prolactin-secreting pituitary adenomas. Zh Vopr Neirokhir Im NN. Burdenko. 2008;(4):36-39; discussion 39. (In Russ.)
  14. Rush S, Cooper PR. Symptom resolution, tumor control, and side effects following postoperative radiotherapy for pituitary macroadenomas. Int J Radiat Oncol Biol Phys. 1997 Mar 15;37(5):1031-1034.
  15. Honegger J, Buchfelder M, Fahlbusch R. Surgical treatment of craniopharyngiomas: endocrinological results. J Neurosurg. 1999 Feb;90(2):251-257. https://doi.org/10.3171/jns.1999.90.2.0251
  16. Klochkova IS, Astafieva LI, Konovalov AN, Kalinin PL, Kutin MA, Fomichev DV, Sharipov OI. Endocrine disorders with craniopharyngioma in adults before and after surgery. Problems of endocrinology. 2016;62(5):61-62. (In Russ.) https://doi.org/10.14341/probl201662561-62
  17. Jungwirth A, Giwercman A, Tournaye H et al. European Association of Urology Working Group on Male Infertility. European Association of Urology guidelines on Male Infertility: the 2012 update. Eur Urol. 2012 Aug;62(2): 324-332. https://doi.org/10.1016/j.eururo.2012.04.048
  18. Shalitin S, Gal M, Goshen Y, et al. Endocrine outcome in long-term survivors of childhood brain tumors. Horm Res Paediatr. 2011;76(2):113-122. https://doi.org/10.1159/000327584
  19. Constine LS, Woolf PD, Cann D, et al. Hypothalamic -pituitary dysfunction after radiation for brain tumors. N Engl J Med. 1993 Jan 14;328(2):87-94.
  20. Agha A, Sherlock M, Brennan S, O’Connor SA, O’Sullivan E, Rogers B, Faul C, Rawluk D, Tormey W, Thompson CJ. Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. J Clin Endocrinol Metab. 2005 Dec;90(12):6355-6360. https://doi.org/10.1210/jc.2005-1525
  21. Gubernatorova EE, Pavlova MG, Melnichenko GA, Mazerkina NA, Sych YuP, Zheludkova OG, Tenedieva VD, Pogorelova AS, Kotlyarevskaya EYu. Endocrine and reproductive abnormalities in the men treated for medulloblastoma and acute lymphoblastic leukemia in the childhood. Problems of endocrinology. 2014;60(1):18-23. (In Russ.) https://doi.org/10.14341/probl201460118-23
  22. Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, Beck LN, Brennan LV, Oktay K; American Society of Clinical Oncology; American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. American Society of Clinical Oncology. J Clin Oncol. 2006 Jun 20;24(18):2917-2931. https://doi.org/10.1200/JCO.2006.06.5888
  23. Oktay K, Harvey BE, Partridge AH, Quinn GP, Reinecke J, Taylor HS, Wallace WH, Wang ET, Loren AW. Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update. J Clin Oncol. 2018 Jul 1;36(19):1994-2001. https://doi.org/10.1200/JCO.2018.78.1914
  24. Mueller BA, Chow EJ, Kamineni A et al. Pregnancy outcomes in female childhood and adolescent cancer survivors: a linked cancer-birth registry analysis. Arch Pediatr Adolesc Med. 2009 Oct;163(10):879-886. https://doi.org/10.1001/archpediatrics.2009.112
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