Severe postoperative intracranial hemorrhagic complications in a neurosurgical patient with von Willebrand disease not diagnosed before surgery (a case report and literature review)

Lubnin A.Yu.

Moscow Regional Research Institute of Obstetrics and Gynecology, Ministry of Health of the Moscow Region, Moscow, Russia, N.N. Burdenko Research Institute of Neurosurgery, Moscow, Russia, Department of Obstetrics and Gynecology, M.F. Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russia

RSCI AuthorID: 370609
Scopus AuthorID: 57192157123
ORCID: 0000-0003-2595-5877

Konovalov A.N.

Burdenko Neurosurgical Institute, Moscow, Russian Federation

Lasunin N.V.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Abramov T.A.

Burdenko National Research Center for Neurosurgery of the Ministry of Health of the Russian Federation, Moscow, Russia

Bulanov A.Yu.

St. Petersburg, Russia

Galstyan G.M.

National Research Center for Hematology, Moscow, Russia

Polevodova O.A.

National Research Center for Hematology, Moscow, Russia

Moshkin A.V.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

ORCID: 0000-0002-9965-4578

Gadjieva O.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Manushkova A.A.

Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047

Severe postoperative intracranial hemorrhagic complications in a neurosurgical patient with von Willebrand disease not diagnosed before surgery (a case report and literature review)

Authors:

Lubnin A.Yu., Konovalov A.N., Lasunin N.V., Abramov T.A., Bulanov A.Yu., Galstyan G.M., Polevodova O.A., Moshkin A.V., Gadjieva O.A., Manushkova A.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2018;82(3): 56‑65

DOI: 10.17116/neiro201882356

Read: 6190 times

To cite this article:

Lubnin AYu, Konovalov AN, Lasunin NV, et al. . Severe postoperative intracranial hemorrhagic complications in a neurosurgical patient with von Willebrand disease not diagnosed before surgery (a case report and literature review). Burdenko's Journal of Neurosurgery. 2018;82(3):56‑65. (In Russ., In Engl.)
https://doi.org/10.17116/neiro201882356

Подписка 2025-2 (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Five-year follow-up after neurosurgery complicated by facial neuropathy. Burdenko's Journal of Neurosurgery. 2024;(4):50-55

Disseminated ependymal dysembryoplastic neuroepithelial tumor: a case report and literature review. Burdenko's Journal of Neurosurgery. 2024;(4):92-99

Disease-free survival after surgical and combined treatment of newly diagnosed craniopharyngiomas in adults. Burdenko's Journal of Neurosurgery. 2024;(5):54-59

Modern concepts of topographic-anatomical classification of craniopharyngiomas: literature review. Burdenko's Journal of Neurosurgery. 2024;(5):110-117

HARDI-CSD tractography in determining the structure of diencephalic pathways in craniopharyngiomas. Burdenko's Journal of Neurosurgery. 2025;(1):30-36

Anatomical and surgical research in neurosurgery. Traditions and trends. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;(1):56-65

The article describes a rare clinical case of a patient with previously undiagnosed von Willebrand disease and basal meningioma; an intracranial neurosurgical intervention was complicated by delayed intracranial hematomas, both at the resected tumor site and distantly. The diagnosis of von Willebrand disease was established only after special hematology tests and only after surgery. Despite the use of specific therapy, the patient died due to intracranial hemorrhagic complications in the postoperative period. The paper discusses the problem of preoperative diagnosis of asymptomatic hemostasis disorders in neurosurgical patients and potential ways of its solution.

Keywords:

hemostasis disorders

von Willebrand disease

neurosurgery

postoperative hematomas

Authors:

Lubnin A.Yu.

RSCI AuthorID: 370609
Scopus AuthorID: 57192157123
ORCID: 0000-0003-2595-5877

Konovalov A.N.

Burdenko Neurosurgical Institute, Moscow, Russian Federation

Lasunin N.V.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Abramov T.A.

Burdenko National Research Center for Neurosurgery of the Ministry of Health of the Russian Federation, Moscow, Russia

Bulanov A.Yu.

St. Petersburg, Russia

Galstyan G.M.

National Research Center for Hematology, Moscow, Russia

Polevodova O.A.

National Research Center for Hematology, Moscow, Russia

Moshkin A.V.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

ORCID: 0000-0002-9965-4578

Gadjieva O.A.

Manushkova A.A.

Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047

List of references:

Federici AB. Clinical and laboratory diagnosis of vWD. Hemathology. 2014;1:524-530. https://doi.org/10.1182/asheducation-2014.1.524
Gerlach R, Krause M, Seifert V, Goerlinger K. Hemostatic and hemorrhagic problems in neurosurgical patients. Acta Neurochir. 2009;151:873-900. https://doi.org/10.1007/s00701-009-0409z
Hamilton MG, Golfimos JG, Pineo GF, Couldwell WT. Handbook of bleeding and coagulation for neurosurgery. Thieme. NY. 2015;423. ISBN 978-1-60406-544-2
Mensah PK, Gooching R. Surgery in patients with inherited bleeding disorders. Anaesthesia. 2015;70:Suppl. 1:112-120;e39-e40. https://doi.org/10.1111/anae.12899
Palmer J, Sparrow O, Iannotti F. Postoperative hematoma: a 5-years survey and identification of avoidable risk factors. Neurosurgery. 1994;35:1061-1065.
Kalfas IH, Little JR. Postoperative hemorrhage: a survey of 4992 intracranial procedures. Neurosurgery. 1988;23:343-347.
Branchford BR, DiPaola J. Making a diagnosis of vWD. Hematology Am Soc Hematol Educ Program. 2012;2012:161-167. https://doi.org/10.1182/asheducation-2012.1.161
Nittby HB, Maltese A, Stahl N. Early postoperative haemathomas in neurosurgery. Acta Neurochir. 2016;158:837-846. https://doi.org/10.1007/s00701-016-2778-4
Lubnin AYu, Karnauchov VV, Moshkin AV, Rylova AV, Shimansky VN. Neurosurgical intervention in a patients received double desagregant theraphy. a case report and literature review. Journal Voprosi Neurochirurgii. 2016;3:91-98. (In Russ.) https://doi.org/10.17116/neuro201680391-98
Rylova AV, Lubnin AYu. A new problem: patient with coronary artery stents. Choose from two evils lesser. Anesthesiologia i reanimatologia. 2013;4:71-76. (In Russ.)
Gerlach R, Raabe A, Scharer I. Postoperative hematoma after surgery for intracranial meningeomas: causes, avoidable risk factors and clinical outcomes. Neurol Res. 2004;26:61-66.
Lillicrap D. Von Willebrand disease: advances in pathogenic understanding, diagnosis, and theraphy. Hematology Am Soc Hematol Educ Program. 2013;2013:254-260. https://doi.org/10.1182/asheducation-2013.1.254
Montgomery RR. von Willebrand disease. In: Goodnight SH, Hathaway WE. (eds.). Disorders of hemostasis and thrombosis. A clinical guide. 2nd ed. McGraw-Hill. USA. 2001;115-126.
Leebeek FWG, Eikenboom JCJ. Von Willebrand’s Disease. New Engl J Med. 2016;375:2067-2080. https://doi.org/10.1056/NEJMra1601561
Shetty S, Kasatkar P, Ghosh K. Pathophysiology of acquired von Willebrand disease: a concise review. Eur J Haematol. 2011;87:99-106. https://doi.org/10.1111/j.1600-0609.2011.01636
Jain A. A rare case of chronic myeloid leukemia with acquired von Willebrand disease presenting as subdural hematoma. J Cancer Res Ther. 2015;11:1022. https://doi.org/10.4103/0973-1482.146136
Scrobohaci ML, Daniel MT, Levy Y, Marolleau JP, Brouet JC. Expression of GpIb on plasma cells in a patient with monoclonal IgG and acquired von Willebrand disease. Br J Haematol. 1993;84:471-475.
Van Durme CMPG, Idema RN, van Guldener C. Two rare complications of glioblastoma multiforme: persistent hiccup and acquired haemophilia A. Netherlands J Med. 2008;66:286-288.
Mikami T, Masauzi N, Niwa J, Houkin K. Acquired factor VIII inhibitors in a patient associated with neurosurgery: case report and review of the literature. Neurosurgery. 2005;57(3):E595.
Li J, Shen H, Hou T. Acquired Hemophilia A in a patient with lumbar disc herniation. Spine. 2009;34:E305-E308.
Ceconi C, Fox KM, Remme WJ, EUROPA Investigators. Pertinent Investigators and the Statistical Committee. ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT. Cardiovasc Res. 2007;73:237-246.
Nakau R, Nomura M, Kida S, Yamashita J, Kinoshita A, Nitta H, Muramatsu N. Subarachnoid hemorrhage associated with von Willebrand’s disease. Neurol Med Chir. 2005;45:631-634.
Park JJ, Kim Ch-H, Lee J-G. Von-Willebrand disease presenting as intractable epistaxis after nasal polipectomy. Case Rep Otolaryng. 2014;2014;Article ID 902071;4. https://doi.org/10.1155/2014/902071
Gastaman G, Hillarp A, Goodeve A. Laboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysis. Haemophilia. 2014;20:65-70. https://doi.org/10.1111/hae.12410
O’Brien SH. Bleeding scores: are they really useful? Hemathology Am Soc Hematol Educ Program. 2012;2012:152-156. https://doi.org/10.1182/asheducation-2012.1.152
Quiroga T, Mezzano D. Is my patient a bleeder? A diagnostic frame- work for mild bleeding disorders. Hematology Am Soc Hematol Educ Program. 2012; 466-474. https://doi.org/10.1182/asheducation-2012.1.466
Rydz N, James PD. The evolution and value of bleeding assessment tools. J Thromb Haemost. 2012;10:2223-2229. https://doi.org/10.1111/j.1538-7836.2012.04923.x
Koscielny J, Ziemer S, Radtke H, Schmutzler M, Pruss A, Sinha P, Salama A, Kiesewetter H, Latza R. A practical concept for preoperative identification of patients with impaired primary hemostasis. Clin Appl Thrombosis Hemostasis. 2004;10:195-204.

Close metadata