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Pronin A.I.

City Clinical Hospital №52 of Moscow Health Department

Dolgushin M.B.

Blokhin Russian Cancer Research Center, Moscow, Russia

Lyuosev A.S.

Blokhin Russian Cancer Research Center, Kashirskoe Shosse, 23, Moscow, Russia, 115478

Odzharova A.A.

Blokhin Russian Cancer Research Center, Moscow, Russia

Nevzorov D.I.

Blokhin Russian Cancer Research Center, Kashirskoe Shosse, 23, Moscow, Russia, 115478

Nechipay E.A.

Blokhin Russian Cancer Research Center, Kashirskoe Shosse, 23, Moscow, Russia, 115478

Gasparyan T.G.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

Capabilities of 18F-FET PET/CT in a patient with brain glioma (a case report and literature review)

Authors:

Pronin A.I., Dolgushin M.B., Lyuosev A.S., Odzharova A.A., Nevzorov D.I., Nechipay E.A., Gasparyan T.G.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2018;82(2): 95‑99

DOI: 10.17116/oftalma201882295-99

Read: 8833 times

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Table of contents

CAPABILITIES OF 18F-FET PET/CT IN A PATIENT WITH BRAIN GLIOMA (A CASE REPORT AND LITERATURE REVIEW)
CAPABILITIES OF 18F-FET PET/CT IN A PATIENT WITH BRAIN GLIOMA (A CASE REPORT AND LITERATURE REVIEW)

To cite this article:

Pronin AI, Dolgushin MB, Lyuosev AS, Odzharova AA, Nevzorov DI, Nechipay EA, Gasparyan TG. Capabilities of 18F-FET PET/CT in a patient with brain glioma (a case report and literature review). Burdenko's Journal of Neurosurgery. 2018;82(2):95‑99. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma201882295-99

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Positron emission tomography combined with computed tomography (PET/CT) enables assessment of not only anatomical and structural but also metabolic changes in tumor mass. 18F-fluoroethyl tyrosine (18F-FET) PET/CT is based on evaluation of transport of 18F-labeled tyrosine in tissues. We present a clinical case of a patient with a newly diagnosed brain tumor, demonstrating the capabilities of 18F-FET PET/CT in assessing the reliable volume and degree of tumor anaplasia, which is important when choosing the treatment approach for a patient.

Keywords:

PET/CT
18F-FET
glioma
anaplastic astrocytoma

Authors:

Pronin A.I.

City Clinical Hospital №52 of Moscow Health Department

Dolgushin M.B.

Blokhin Russian Cancer Research Center, Moscow, Russia

Lyuosev A.S.

Blokhin Russian Cancer Research Center, Kashirskoe Shosse, 23, Moscow, Russia, 115478

Odzharova A.A.

Blokhin Russian Cancer Research Center, Moscow, Russia

Nevzorov D.I.

Blokhin Russian Cancer Research Center, Kashirskoe Shosse, 23, Moscow, Russia, 115478

Nechipay E.A.

Blokhin Russian Cancer Research Center, Kashirskoe Shosse, 23, Moscow, Russia, 115478

Gasparyan T.G.

Department of Oncological Neurosurgery, Blokhin Russian Cancer Research Center, Moscow, Russia

Close metadata

References:

  1. Bondy M, Scheurer M, Malmer B, Barnholtz-Sloan J, Davis F, Il’yasova D, Kruchko C, McCarthy B, Rajaraman P, Schwartzbaum J, Sadetzki S, Schlehofer B, Tihan T, Wiemels J, Wrensch M, Buffler P. Brain tumor epidemiology: consensus from the brain tumor epidemiology consortium. Cancer. 2008;113(S7):1953-1968. https://doi.org/10.1002/cncr.23741
  2. Absalyamova OV, Aleshin VA, Anikeeva OYu, Bekyashev AKh, Belov DM, Gorbunova VA, Karakhan VB, Kobyakov GL, Konovalov AN, Kornienko VN, Krivoshapkin AL, Loshakov VA, Medvedev SV, Mitrofanov AA, Mikhina ZP, Moskvina EA, Naskhletashvili DR, Olyushin VE, Poddubskii AA, Potapov AA, Ryzhova MV, Tanyashin SV, Trunin YuYu, Ulitin AYu, Shishkina LV. Klinicheskie rekomendatsii po diagnostike i lecheniyu bol’nykh s pervichnymi opukholyami golovnogo mozga. М. 2014;8-10. (In Russ.) https://doi.org/10.14341/ket2007346-8
  3. Weise G, Stoll G. Magnetic resonance imaging of blood brain/nerve barrier dysfunction and leukocyte infiltration: closely related or discordant? Frontiers in Neurology. 2012;3. https://doi.org/10.3389/fneur.2012.00178
  4. Jain R, Ellika S, Scarpace L, Schultz L, Rock J, Gutierrez J, Patel S, Ewing J, Mikkelsen T. Quantitative estimation of permeability surface-area product in astroglial brain tumors using perfusion CT and correlation with histopathologic grade. American Journal of Neuroradiology. 2008;29(4):694-700. https://doi.org/10.3174/ajnr.a0899
  5. Dolgushin MB, Pronin IN, Fadeeva LM, Turkin AM, Il’yalov SR, Rotin DL, Golanov AV, Anpilogov VE, Kornienko VN. Impulsnaya posledovatel’nost’ SWAN (3,0 TESLA MRT) i KT-perfuziya v kompleksnoi otsenke strukturnykh osobennostei metastazov v golovnom mozge i zlokachestvennykh gliom. Luchevaya diagnostika i terapiya. 2012;(3):41-50. (In Russ.)
  6. Sergeev PV, Polyaev YuA, Yudin AL, Shimanovskii NL. Kontrastnye sredstva. M.: Izvestiya. 2007;496. (In Russ.)
  7. la Fougere C, Suchorska B, Bartenstein P, Kreth F, Tonn J. Molecular imaging of gliomas with PET: opportunities and limitations. Neuro-Oncology. 2011;13(8):806-819. https://doi.org/10.1093/neuonc/nor054
  8. Pauleit D, Stoffels G, Bachofner A, Floeth F, Sabel M, Herzog H, Tellmann L, Jansen P, Reifenberger G, Hamacher K, Coenen H, Langen K. Comparison of 18F-FET and 18F-FDG PET in brain tumors. Nuclear Medicine and Biology. 2009;36(7):779-787. https://doi.org/10.1016/j.nucmedbio.2009.05.005
  9. Galldiks N, Rapp M, Stoffels G, Fink G, Shah N, Coenen H, Sabel M, Langen K. Response assessment of bevacizumab in patients with recurrent malignant glioma using [18F] Fluoroethyl-l-tyrosine PET in comparison to MRI. European Journal of Nuclear Medicine and Molecular Imaging. 2012;40(1):22-33. https://doi.org/10.1007/s00259-012-2251-4
  10. Hara T, Kosaka N, Shinoura N, Kondo T. PET imaging of brain tumor with (methyl-11C) choline. The Journal of Nuclear Medicine. 1997;38(6):842.
  11. Langen K, Jarosch M, Mühlensiepen H, Hamacher K, Bröer S, Jansen P, Zilles K, Coenen H. Comparison of fluorotyrosines and methionine uptake in F98 rat gliomas. Nuclear Medicine and Biology. 2003;30(5):501-508. https://doi.org/10.1016/s0969-8051(03)00023-4
  12. Kwee S, Ko J, Jiang C, Watters M, Coel M. Solitary brain lesions enhancing at MR imaging: evaluation with fluorine 18-Fluorocholine PET. Radiology. 2007;244(2):557-565. https://doi.org/10.1148/radiol.2442060898
  13. Wyss M, Spaeth N, Biollaz G, Pahnke J, Alessi P, Trachsel E, Treyer V, Weber B, Neri D, Buck A. Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis. Journal of Nuclear Medicine. 2007;48(4):608-614. https://doi.org/10.2967/jnumed.106.036251
  14. Langen K, Hamacher K, Weckesser M, Floeth F, Stoffels G, Bauer D, Coenen H, Pauleit D. O-(2-[18F]fluoroethyl)-l-tyrosine: uptake mechanisms and clinical applications. Nuclear Medicine and Biology. 2006;33(3):287-294. https://doi.org/10.1016/j.nucmedbio.2006.01.002
  15. Weckesser M, Matheja P, Rickert C, Löttgen J, Palkovic S, Riemann B, Paulus W, Wassmann H, Schober O. Evaluation of the extension of cerebral gliomas by scintigraphy. Strahlentherapie und Onkologie. 2000;176(4):180-185. https://doi.org/10.1007/s000660050054
  16. Stöber B, Tanase U, Herz M, Seidl C, Schwaiger M, Senekowitsch-Schmidtke R. Differentiation of tumour and inflammation: characterisation of [methyl-3H]methionine (MET) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cells. European Journal of Nuclear Medicine and Molecular Imaging. 2006;33(8):932-939. https://doi.org/10.1007/s00259-005-0047-5
  17. Del Amo E, Urtti A, Yliperttula M. Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2. European Journal of Pharmaceutical Sciences. 2008;35(3):161-174. https://doi.org/10.1016/j.ejps.2008.06.015
  18. Jansen N, Suchorska B, Wenter V, Eigenbrod S, Schmid-Tannwald C, Zwergal A, Niyazi M, Drexler M, Bartenstein P, Schnell O, Tonn J, Thon N, Kreth F, la Fougere C. Dynamic 18F-FET PET in newly diagnosed astrocytic low-grade glioma identifies high-risk patients. Journal of Nuclear Medicine. 2013;55(2):198-203. https://doi.org/10.2967/jnumed.113.122333
  19. Pöpperl G, Kreth FW, Herms J, Koch W, Mehrkens JH, Gildehaus FJ, Kretzschmar HA, Tonn JC. Tatsch K. Analysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods? Journal of nuclear medicine. 2006;47(3):393-403.
  20. Pöpperl G, Kreth F, Mehrkens J, Herms J, Seelos K, Koch W, Gildehaus F, Kretzschmar H, Tonn J, Tatsch K. FET PET for the evaluation of untreated gliomas: correlation of FET uptake and uptake kinetics with tumour grading. European Journal of Nuclear Medicine and Molecular Imaging. 2007;34(12):1933-1942. https://doi.org/10.1007/s00259-007-0534-y
  21. Jansen N, Graute V, Armbruster L, Suchorska B, Lutz J, Eigenbrod S, Cumming P, Bartenstein P, Tonn J, Kreth F, la Fougère C. MRI-suspected low-grade glioma: is there a need to perform dynamic FET PET? European Journal of Nuclear Medicine and Molecular Imaging. 2012;39(6):1021-1029. https://doi.org/10.1007/s00259-012-2109-9
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