Introduction. The combination of traumatic brain injury with extracranial lesions is observed in 50-70% of cases. The results of treatment of patients with concomitant traumatic brain injury are much worse than with isolated injuries, deaths on different data ranges from 12 to 69%. Purpose. To study the effect of diagnostic and therapeutic measures at different stages of health care co-head injury victims and to create an algorithm of the best diagnosis and treatment of patients according to specific region. Material and methods. 615 patients with concomitant TBI admitted to the Andijan branch of the Republican Research Centre of Emergency Medicine (Uzbekistan) between 2005 and 2011. Results. The average age of victims was 44.2±1.2 years (16-76 years). Diffuse brain damage was detected in 193 (31.4%) patients. Died in the hospital 95 (15.4%) of the injured. The most common cause was traffic accident. In the first days after injury leading cause of death was blood loss and shock, and only then - the massive intracranial injuries (damage?) and intracranial hematoma. Conclusion. Critical, in addition to establishing the nature of head trauma and associated injuries, is timely diagnosis and treatment of blood loss and shock.