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Turgunkhujaev O.E.

Burnazyan Federal Medical and Biological Agency;
Network Of Family Medical Centers No. 1

Kupreychik V.L.

Moscow Multidisciplinary Clinical Center «Kommunarka»

Brand P.Y.

Network Of Family Medical Centers No. 1

Bril E.V.

Burnazyan Federal Medical and Biophysical Center

Mills’ syndrome

Authors:

Turgunkhujaev O.E., Kupreychik V.L., Brand P.Y., Bril E.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(10): 138‑142

DOI: 10.17116/jnevro2022122101138

Read: 3521 times

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Table of contents

MILLS’ SYNDROME
MILLS’ SYNDROME

To cite this article:

Turgunkhujaev OE, Kupreychik VL, Brand PY, Bril EV. Mills’ syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(10):138‑142. (In Russ.)
https://doi.org/10.17116/jnevro2022122101138

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Mills’ syndrome is an idiopathic, slowly progressive ascending spastic hemiparesis. Some authors consider it as a unilateral variant of progressive lateral sclerosis. Due to the rarity of the disease and the slow clinical course, this article presents a clinical case and discusses the diagnostic criteria for the syndrome.

Keywords:

Mills’ syndrome
progressive hemiparesis
hemiparetic form of amyotrophic sclerosis

Authors:

Turgunkhujaev O.E.

Burnazyan Federal Medical and Biological Agency;
Network Of Family Medical Centers No. 1

Kupreychik V.L.

Moscow Multidisciplinary Clinical Center «Kommunarka»

Brand P.Y.

Network Of Family Medical Centers No. 1

Bril E.V.

Burnazyan Federal Medical and Biophysical Center

Received:

29.07.2022

Accepted:

04.08.2022

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References:

  1. Mills CK. A case of unilateral progressive ascending paralysis, probably representing a new form of degenerative disease. J Nerv Ment Dis. 1900;27(4):195-200. 
  2. Mills CK. Unilateral ascending paralysis and unilateral descending paralysis. Their clinical varieties and their pathologic causes. J Am Med Assoc. 1906;47(20):1638-1645.
  3. Ponomarev VV. Sindrom Millsa: opisanie nabljudenija i obzor literatury. Neurological Journal. 2013;1:23-29. (In Russ.).
  4. Habirov FA, Kuhnina TM, Sjus’kova AR. Sindrom Millsa — redkij piramidnyj sindrom. Vertebronevrologija. 2004;11(1-2):126-129. (In Russ.).
  5. Jaiser SR, Mitra D, Williams TL, Baker MR. Mills’ syndrome revisited. J Neurol. 2019;266(3):667-679. 
  6. Maragakis NJ, Holland NR, Corse AM. Hemiparetic Primary Lateral Sclerosis: Revisiting Mills Syndrome. Case Rep Neurol. 2015;7(3):191-195.  https://doi.org/10.1159/000440713
  7. Gastaut JL, Bartolomei F. Mills’ syndrome: ascending (or descending) progressive hemiplegia: a hemiplegic form of primary lateral sclerosis? J Neurol Neurosurg Psychiatry. 1994;57(10):1280-1281. https://doi.org/10.1136/jnnp.57.10.1280
  8. Fernandes PM, Turner MR, Zeidler M, Smith C, Davenport R. Progressive hemiparesis in a 75-year-old man. Pract Neurol. 2015;15(1):63-71.  https://doi.org/10.1136/practneurol-2014-000950
  9. Thompson AJ, Banwell BL, Barkhof F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17(2):162-173.  https://doi.org/10.1016/S1474-4422(17)30470-2
  10. Kassubek J, Ludolph AC, Müller H-P. Neuroimaging of motor neuron diseases. Ther Adv Neurol Disord. 2012;5(2):119-127.  https://doi.org/10.1177/1756285612437562
  11. de Carvalho M, Kiernan MC, Pullman SL, et al. Neurophysiological features of primary lateral sclerosis. Amyotroph Lateral Scler Front Degener. 2020;21(sup1):11-17.  https://doi.org/10.1080/21678421.2020.1837174
  12. Tokimura R, Murakami T, Ugawa Y. Central motor conduction time reveals upper motor neuron involvement masked by lower motor neuron impairment in a significant portion of patients with amyotrophic lateral sclerosis. Clin Neurophysiol. 2020;131(8):1896-1901. https://doi.org/10.1016/j.clinph.2020.05.021
  13. Kuipers-Upmeijer J, de Jager AEJ, Hew JM, et al. Primary lateral sclerosis: clinical, neurophysiological, and magnetic resonance findings. J Neurol Neurosurg Psychiatry. 2001;71(5):615-620.  https://doi.org/10.1136/jnnp.71.5.615
  14. Huynh W, Simon NG, Grosskreutz J, et al. Assessment of the upper motor neuron in amyotrophic lateral sclerosis. Clin Neurophysiol. 2016;127(7):2643-2660. https://doi.org/10.1016/j.clinph.2016.04.025
  15. Statland JM, Barohn RJ, Dimachkie MM, et al. Primary Lateral Sclerosis. Neurol Clin. 2015;33(4):749-760.  https://doi.org/10.1016/j.ncl.2015.07.007
  16. Mills CK, Spiller WG. A case of progressively developing hemiplegia. Later becoming triplegia, resulting from primary degeneration of the pyramidal tracts. J Nerv Ment Dis. 1989;30:385-397. 
  17. Geevasinga N, den Bos M, Menon P, Vucic S. Utility of Transcranial Magnetic Simulation in Studying Upper Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis. Brain Sci. 2021;11(7):23-29.  https://doi.org/10.3390/brainsci11070906
  18. Schriefer TN, Hess CW, Mills KR, Murray NMF. Central motor conduction studies in motor neurone disease using magnetic brain stimulation. Electroencephalogr Clin Neurophysiol. 1989;74(6):431-437.  https://doi.org/10.1016/0168-5597(89)90032-4
  19. Ellis CM, Simmons A, Dawson JM, et al. Distinct hyperintense MRI signal changes in the corticospinal tracts of a patient with motor neuron disease. Amyotroph Lateral Scler Mot Neuron Disord. 1999;1(1):41-44.  https://doi.org/10.1080/146608299750138777
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