The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Turgunkhujaev O.E.

Burnazyan Federal Medical and Biological Agency;
Network Of Family Medical Centers No. 1

Kupreychik V.L.

Moscow Multidisciplinary Clinical Center «Kommunarka»

Brand P.Y.

Network Of Family Medical Centers No. 1

Bril E.V.

Burnazyan Federal Medical and Biophysical Center

Mills’ syndrome

Authors:

Turgunkhujaev O.E., Kupreychik V.L., Brand P.Y., Bril E.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(10): 138‑142

DOI: 10.17116/jnevro2022122101138

Views: 2116

Downloaded: 106

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Turgunkhujaev OE, Kupreychik VL, Brand PY, Bril EV. Mills’ syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(10):138‑142. (In Russ.)
https://doi.org/10.17116/jnevro2022122101138

 
МСФ на ЯМ
Close metadata

Mills’ syndrome is an idiopathic, slowly progressive ascending spastic hemiparesis. Some authors consider it as a unilateral variant of progressive lateral sclerosis. Due to the rarity of the disease and the slow clinical course, this article presents a clinical case and discusses the diagnostic criteria for the syndrome.

Keywords:

Mills’ syndrome
progressive hemiparesis
hemiparetic form of amyotrophic sclerosis

Authors:

Turgunkhujaev O.E.

Burnazyan Federal Medical and Biological Agency;
Network Of Family Medical Centers No. 1

Kupreychik V.L.

Moscow Multidisciplinary Clinical Center «Kommunarka»

Brand P.Y.

Network Of Family Medical Centers No. 1

Bril E.V.

Burnazyan Federal Medical and Biophysical Center

Received:

29.07.2022

Accepted:

04.08.2022

List of references:

  1. Mills CK. A case of unilateral progressive ascending paralysis, probably representing a new form of degenerative disease. J Nerv Ment Dis. 1900;27(4):195-200. 
  2. Mills CK. Unilateral ascending paralysis and unilateral descending paralysis. Their clinical varieties and their pathologic causes. J Am Med Assoc. 1906;47(20):1638-1645.
  3. Ponomarev VV. Sindrom Millsa: opisanie nabljudenija i obzor literatury. Neurological Journal. 2013;1:23-29. (In Russ.).
  4. Habirov FA, Kuhnina TM, Sjus’kova AR. Sindrom Millsa — redkij piramidnyj sindrom. Vertebronevrologija. 2004;11(1-2):126-129. (In Russ.).
  5. Jaiser SR, Mitra D, Williams TL, Baker MR. Mills’ syndrome revisited. J Neurol. 2019;266(3):667-679. 
  6. Maragakis NJ, Holland NR, Corse AM. Hemiparetic Primary Lateral Sclerosis: Revisiting Mills Syndrome. Case Rep Neurol. 2015;7(3):191-195.  https://doi.org/10.1159/000440713
  7. Gastaut JL, Bartolomei F. Mills’ syndrome: ascending (or descending) progressive hemiplegia: a hemiplegic form of primary lateral sclerosis? J Neurol Neurosurg Psychiatry. 1994;57(10):1280-1281. https://doi.org/10.1136/jnnp.57.10.1280
  8. Fernandes PM, Turner MR, Zeidler M, Smith C, Davenport R. Progressive hemiparesis in a 75-year-old man. Pract Neurol. 2015;15(1):63-71.  https://doi.org/10.1136/practneurol-2014-000950
  9. Thompson AJ, Banwell BL, Barkhof F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17(2):162-173.  https://doi.org/10.1016/S1474-4422(17)30470-2
  10. Kassubek J, Ludolph AC, Müller H-P. Neuroimaging of motor neuron diseases. Ther Adv Neurol Disord. 2012;5(2):119-127.  https://doi.org/10.1177/1756285612437562
  11. de Carvalho M, Kiernan MC, Pullman SL, et al. Neurophysiological features of primary lateral sclerosis. Amyotroph Lateral Scler Front Degener. 2020;21(sup1):11-17.  https://doi.org/10.1080/21678421.2020.1837174
  12. Tokimura R, Murakami T, Ugawa Y. Central motor conduction time reveals upper motor neuron involvement masked by lower motor neuron impairment in a significant portion of patients with amyotrophic lateral sclerosis. Clin Neurophysiol. 2020;131(8):1896-1901. https://doi.org/10.1016/j.clinph.2020.05.021
  13. Kuipers-Upmeijer J, de Jager AEJ, Hew JM, et al. Primary lateral sclerosis: clinical, neurophysiological, and magnetic resonance findings. J Neurol Neurosurg Psychiatry. 2001;71(5):615-620.  https://doi.org/10.1136/jnnp.71.5.615
  14. Huynh W, Simon NG, Grosskreutz J, et al. Assessment of the upper motor neuron in amyotrophic lateral sclerosis. Clin Neurophysiol. 2016;127(7):2643-2660. https://doi.org/10.1016/j.clinph.2016.04.025
  15. Statland JM, Barohn RJ, Dimachkie MM, et al. Primary Lateral Sclerosis. Neurol Clin. 2015;33(4):749-760.  https://doi.org/10.1016/j.ncl.2015.07.007
  16. Mills CK, Spiller WG. A case of progressively developing hemiplegia. Later becoming triplegia, resulting from primary degeneration of the pyramidal tracts. J Nerv Ment Dis. 1989;30:385-397. 
  17. Geevasinga N, den Bos M, Menon P, Vucic S. Utility of Transcranial Magnetic Simulation in Studying Upper Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis. Brain Sci. 2021;11(7):23-29.  https://doi.org/10.3390/brainsci11070906
  18. Schriefer TN, Hess CW, Mills KR, Murray NMF. Central motor conduction studies in motor neurone disease using magnetic brain stimulation. Electroencephalogr Clin Neurophysiol. 1989;74(6):431-437.  https://doi.org/10.1016/0168-5597(89)90032-4
  19. Ellis CM, Simmons A, Dawson JM, et al. Distinct hyperintense MRI signal changes in the corticospinal tracts of a patient with motor neuron disease. Amyotroph Lateral Scler Mot Neuron Disord. 1999;1(1):41-44.  https://doi.org/10.1080/146608299750138777

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.