The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Shabalina A.A.
Research Center of Neurology
Shamtieva K.V.
Research Center of Neurology
Krotenkova M.V.
Research Center of Neurology
Salt sensitivity and osmotic fragility are newly specified risk factors for age-related cerebral microangiopathy
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3): 77‑85
Views: 6370
Downloaded: 112
To cite this article:
Dobrynina LA, Shabalina AA, Shamtieva KV, Krotenkova MV, Kalashnikova LA. Salt sensitivity and osmotic fragility are newly specified risk factors for age-related cerebral microangiopathy. S.S. Korsakov Journal of Neurology and Psychiatry.
2021;121(3):77‑85. (In Russ.)
https://doi.org/10.17116/jnevro202112103177
To assess individual values of salt sensitivity and osmotic fragility on the patient’s erythrocytes and evaluate predictive ability of these parameters in the development of cerebral small vessel disease (CSVD).
The study included 73 patients with CSVD (48 women, mean age 60.1±6.5 years) and 19 volunteers (14 women, mean age 56.9±5.4 years). Their erythrocytes were used for the measurement of salt-sensitivity by a modified salt blood test and of osmotic fragility by the classical osmotic fragility test. Binary logistic regression was used to assess the ability of salt-sensitivity and osmotic fragility to predict CSVD development. ROC analysis was used to find out the optimal threshold values of these predictors, their sensitivity and specificity.
An increase in salt sensitivity (cut-off: 8.5 mm/h; sensitivity 64%, specificity 74%) and osmotic fragility (cut-off: 0.62 u.a.; sensitivity 52%, specificity 90%) or their simultaneous use (p of the model <0.000001, cut-off 0.62; sensitivity 88%, specificity 68%) are the independent predictors of CSVD. An increase in salt sensitivity and osmotic fragility is also independently associated with the acceleration of severity of white matter hyperintensities according to Fazekas stages (p=0.019 and 0.004, respectively).
The possibility of prediction of CSVD according to an increase in salt sensitivity and osmotic fragility allows us to consider them as the risk factors of CSVD. The standardization of these tests for use in clinical practice is necessary to identify the risk group for CSVD and its individual prevention.
Keywords:
Authors:
Shabalina A.A.
Research Center of Neurology
Shamtieva K.V.
Research Center of Neurology
Krotenkova M.V.
Research Center of Neurology
Received:
14.05.2020
Accepted:
09.06.2020
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.