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Dobrynina L.A.

Research Center of Neurology

Shabalina A.A.

Research Center of Neurology

Shamtieva K.V.

Research Center of Neurology

Krotenkova M.V.

Research Center of Neurology

Kalashnikova L.A.

Research Center of Neurology

Salt sensitivity and osmotic fragility are newly specified risk factors for age-related cerebral microangiopathy

Authors:

Dobrynina L.A., Shabalina A.A., Shamtieva K.V., Krotenkova M.V., Kalashnikova L.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3): 77‑85

DOI: 10.17116/jnevro202112103177

Read: 7640 times

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Table of contents

SALT SENSITIVITY AND OSMOTIC FRAGILITY ARE NEWLY SPECIFIED RISK FACTORS FOR AGE-RELATED CEREBRAL MICROANGIOPATHY
SALT SENSITIVITY AND OSMOTIC FRAGILITY ARE NEWLY SPECIFIED RISK FACTORS FOR AGE-RELATED CEREBRAL MICROANGIOPATHY

To cite this article:

Dobrynina LA, Shabalina AA, Shamtieva KV, Krotenkova MV, Kalashnikova LA. Salt sensitivity and osmotic fragility are newly specified risk factors for age-related cerebral microangiopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3):77‑85. (In Russ.)
https://doi.org/10.17116/jnevro202112103177

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

AIM/

To assess individual values of salt sensitivity and osmotic fragility on the patient’s erythrocytes and evaluate predictive ability of these parameters in the development of cerebral small vessel disease (CSVD).

MATERIAL AND METHODS

The study included 73 patients with CSVD (48 women, mean age 60.1±6.5 years) and 19 volunteers (14 women, mean age 56.9±5.4 years). Their erythrocytes were used for the measurement of salt-sensitivity by a modified salt blood test and of osmotic fragility by the classical osmotic fragility test. Binary logistic regression was used to assess the ability of salt-sensitivity and osmotic fragility to predict CSVD development. ROC analysis was used to find out the optimal threshold values of these predictors, their sensitivity and specificity.

RESULTS

An increase in salt sensitivity (cut-off: 8.5 mm/h; sensitivity 64%, specificity 74%) and osmotic fragility (cut-off: 0.62 u.a.; sensitivity 52%, specificity 90%) or their simultaneous use (p of the model <0.000001, cut-off 0.62; sensitivity 88%, specificity 68%) are the independent predictors of CSVD. An increase in salt sensitivity and osmotic fragility is also independently associated with the acceleration of severity of white matter hyperintensities according to Fazekas stages (p=0.019 and 0.004, respectively).

CONCLUSION

The possibility of prediction of CSVD according to an increase in salt sensitivity and osmotic fragility allows us to consider them as the risk factors of CSVD. The standardization of these tests for use in clinical practice is necessary to identify the risk group for CSVD and its individual prevention.

Keywords:

cerebral microangiopathy
cerebral small vessel disease
white matter hyperintensities
salt sensitivity
osmotic fragility
glycocalyx
Na+/K+-ATPas

Authors:

Dobrynina L.A.

Research Center of Neurology

Shabalina A.A.

Research Center of Neurology

Shamtieva K.V.

Research Center of Neurology

Krotenkova M.V.

Research Center of Neurology

Kalashnikova L.A.

Research Center of Neurology

Received:

14.05.2020

Accepted:

09.06.2020

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