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Katan E.A.

Orenburg State Medical University

Neurobiological effects of childhood abuse and neglect as a predisposing factor to substance use disorder

Authors:

Katan E.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(11): 141‑147

DOI: 10.17116/jnevro2020120111141

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To cite this article:

Katan EA. Neurobiological effects of childhood abuse and neglect as a predisposing factor to substance use disorder. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(11):141‑147. (In Russ.)
https://doi.org/10.17116/jnevro2020120111141

 
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The article presents data from research literature on the neurobiological consequences of abuse and neglect in childhood. It is shown that early life stress affects the trajectory of brain development, changes the patterns of cognitive behavioral control and reception of rewards, potentially increasing the risk of substance misuse. The combination of this factor with an immature prefrontal cortex can dramatically increase the liability to the development of substance dependence.

Keywords:

child abuse
child neglect
neurodevelopment
neuroimaging
substance use disorder

Authors:

Katan E.A.

Orenburg State Medical University

Received:

15.05.2020

Accepted:

28.06.2020

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