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Miroshnichenko I.I.

Mental Health Research Center, Moscow

Iakovleva O.B.

Safarova T.P.

Shipilova E.S.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia" RAMN, Moskva

Baymeeva N.V.

Mental Health Research Center, Moscow

The content of N-acetylaspartate in depressed elderly patients during therapy with antidepressants and actovegin

Authors:

Miroshnichenko I.I., Iakovleva O.B., Safarova T.P., Shipilova E.S., Baymeeva N.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(4): 38‑42

DOI: 10.17116/jnevro201911904138

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To cite this article:

Miroshnichenko II, Iakovleva OB, Safarova TP, Shipilova ES, Baymeeva NV. The content of N-acetylaspartate in depressed elderly patients during therapy with antidepressants and actovegin. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(4):38‑42. (In Russ.)
https://doi.org/10.17116/jnevro201911904138

 
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Objective. To assess the plasma level of N-acetylaspartate (NAA) before and after combined therapy with antidepressants and actovegin in a group of elderly patients diagnosed with depression. Material and methods. Nineteen patients, 7 men and 12 women, mean age 70.5±5.8 years, were studied using clinical examination and psychometric scales as well as computed tomography (CT). NAA plasma levels were determined. The duration of treatment with antidepressants (venlafaxine, fluvoxamine) and actovegin was 28 days, patients were examined at baseline and on the 28th day of treatment. Results and conclusion. The NAA plasma level was reduced in patients compared to healthy volunteers. The increase of this indicator after treatment reflected a significant improvement on clinical and psychometric measures. The dynamics of NAA changes (increase or decrease) showed heterogeneity in the group of patients, which was not related to the efficacy of treatment but was correlated with comorbid diseases, in particular vascular diseases, and CT changes (leukoaraiosis). The authors consider the results of this study as preliminary.

Keywords:

depression in older adults
antidepressants
actovegin
N-acetylaspartate

Authors:

Miroshnichenko I.I.

Mental Health Research Center, Moscow

Iakovleva O.B.

Safarova T.P.

Shipilova E.S.

FGBU "Nauchnyĭ tsentr psikhicheskogo zdorov'ia" RAMN, Moskva

Baymeeva N.V.

Mental Health Research Center, Moscow

List of references:

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  12. Baymeeva NV, Miroshnichenko II. N-acetylaspartate is a biomarker of psychiatric and neurological disorders. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2015;115: 8:54-58. (In Russ.) https://doi.org/10.17116/jnevro20151158194-98
  13. Ruggieri M, Tortorella C, Ceci E. Age-related changes of serum N-acetylaspartate in healthy control. Research letters. J Age and Ageing. 2011;40(3):391-394. https://doi.org/10.1093/ageing/afr021
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  20. Baymeeva NV, Platova AI, Safarova TP, Yakovleva OB, Sheshenin VS, Shipilova ES, Kornilov VV, Miroshnichenko II. Rol’ biomarkerov v diagnostike i terapii depressii. Digest Theses of XXIV Ross. Nat. Congress «Man and medicine». M. 2017;120. (In Russ.)
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