S100B protein in the blood of children with autism spectrum disorders

Golubova T.F.

Scientific Research Institute of Children’s Balneology, Physiotherapy and Medical Rehabilitation, Evpatoria, Russia

Tsukurova L.A.

Kraevaia klinicheskaia bol'nitsa #1 im. prof. S.V. Ochapovskogo, Krasnodar

Korsunskaya L.L.

Georgievsky Medical Academy, Simferopol, Russia, Crimean Federal University Vernadsky, Simferopol, Russia

Osipyan R.R.

Kuban State Medical University, Krasnodar, Russia

Vlasenko S.V.

Georgievsky Medical Academy, Simferopol, Russia, Crimean Federal University Vernadsky, Simferopol, Russia

Savchuk E.A.

Vernadsky Crimean Federal University, Georgievsky Medical Academy , Simferopol, Russia

S100B protein in the blood of children with autism spectrum disorders

Authors:

Golubova T.F., Tsukurova L.A., Korsunskaya L.L., Osipyan R.R., Vlasenko S.V., Savchuk E.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(12): 76‑83

DOI: 10.17116/jnevro201911912176

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To cite this article:

Golubova TF, Tsukurova LA, Korsunskaya LL, Osipyan RR, Vlasenko SV, Savchuk EA. S100B protein in the blood of children with autism spectrum disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(12):76‑83. (In Russ.)
https://doi.org/10.17116/jnevro201911912176

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Objective. To evaluate the plasma content of S100B protein in children with autism spectrum disorders (ASD). Material and methods. Forty-five children with autism (item F84 of ICD-10), aged from 6 to 15 years, were examined. The control group (KG) consisted of 25 healthy children. The study included examination by specialists, an assessment of the severity of the disease using the Children’s Rating Scale of Autism scale (CARS), evaluation of S100B in blood serum. Results. The content of S100B in children with autism was significantly higher in comparison with KG. The level of S100B in children with ASD with abnormal development of brain structures (MRI) was significantly higher compared with KG and a group of children without signs of disturbance of brain structures. S100B levels were higher in children with severe ASD, and differed from controls in children with moderate ASD. Conclusions. The majority of children with ASD show signs of stress of neuroprotective mechanisms, and children with anomalies of brain structures have signs of hypoxia of the brain and damage of the blood-brain barrier.

Keywords:

autism

children

Children’s Rating Scale of Autism (CARS)

S100B protein

disturbance of the blood-brain barrier

Authors:

Golubova T.F.

Scientific Research Institute of Children’s Balneology, Physiotherapy and Medical Rehabilitation, Evpatoria, Russia

Tsukurova L.A.

Kraevaia klinicheskaia bol'nitsa #1 im. prof. S.V. Ochapovskogo, Krasnodar

Korsunskaya L.L.

Georgievsky Medical Academy, Simferopol, Russia, Crimean Federal University Vernadsky, Simferopol, Russia

Osipyan R.R.

Kuban State Medical University, Krasnodar, Russia

Vlasenko S.V.

Georgievsky Medical Academy, Simferopol, Russia, Crimean Federal University Vernadsky, Simferopol, Russia

Savchuk E.A.

Vernadsky Crimean Federal University, Georgievsky Medical Academy , Simferopol, Russia

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