The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Gavrilov S.G.

Pirogov Russian National Research Medical University

Vasilieva G.Yu.

Institute of Bio-Medical Problems of the Russian Academy of Sciences

Vasiliev I.M.

Institute of Bio-Medical Problems of the Russian Academy of Sciences

Efremova O.I.

Pirogov Russian National Research Medical University

Grishenkova A.S.

Pirogov Russian National Research Medical University

Neurobiological aspects of venous pelvic pain

Authors:

Gavrilov S.G., Vasilieva G.Yu., Vasiliev I.M., Efremova O.I., Grishenkova A.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11): 74‑79

DOI: 10.17116/jnevro201911911174

Read: 1036 times

Download PDF (RU)
Contact the author
Table of contents

NEUROBIOLOGICAL ASPECTS OF VENOUS PELVIC PAIN
NEUROBIOLOGICAL ASPECTS OF VENOUS PELVIC PAIN

To cite this article:

Gavrilov SG, Vasilieva GYu, Vasiliev IM, Efremova OI, Grishenkova AS. Neurobiological aspects of venous pelvic pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11):74‑79. (In Russ.)
https://doi.org/10.17116/jnevro201911911174

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

Mechanisms of the development of pain in chronic venous diseases (CVD), including pelvic congestion syndrome (PCS), are understudied. The existing hypotheses of the occurrence of venous pelvic pain (VVP) do not allow to answer the question why some patients have no pain syndrome while others have very pronounced pain despite the same morphofunctional changes in the pelvic veins. This review presents current hypotheses of the VPP development, data on some vasoactive neuropeptides (endothelin, calcitonin gene-related peptide, and substance P), their role in the modulation of vascular tone and sensation of pain, possible association between neurogenic inflammation and VPP and provides a rationale for studying the activity of these neurotransmitters in the treatment of PCS and pelvic pain.

Keywords:

venous pelvic pain
pelvic congestion syndrome
neuropeptides
endothelin
calcitonin gene-related peptide
substance P
treatment of venous pain

Authors:

Gavrilov S.G.

Pirogov Russian National Research Medical University

Vasilieva G.Yu.

Institute of Bio-Medical Problems of the Russian Academy of Sciences

Vasiliev I.M.

Institute of Bio-Medical Problems of the Russian Academy of Sciences

Efremova O.I.

Pirogov Russian National Research Medical University

Grishenkova A.S.

Pirogov Russian National Research Medical University

Received:

25.04.2019

Accepted:

04.07.2019

Close metadata

References:

  1. Taylor HC. Vascular congestion and hyperemia; their effect on function and structure in the female reproductive organs. Part I. Am J Obstet Gynecol. 1949;57(2):211-230.  https://doi.org/10.1016/0002-9378(49)90422-6
  2. Hobbs JT. The pelvic congestion syndrome. Practitioner. 1976;216:529-540. 
  3. Ignacio EA, Dua R, Sarin S, Harper AS, Yim D, Mathur V, Venbrux AC. Pelvic congestion syndrome: diagnosis and treatment. Semin Intervent Radiol. 2008;25:361-368.  https://doi.org/10.1055/s-0028-1102998
  4. Dos Santos SJ, Holdstock JM, Harrison CC, Lopez AJ, Whiteley MS. Ovarian Vein Diameter Cannot Be Used as an Indicator of Ovarian Venous Reflux. Eur J Vasc Endovasc Surg. 2015;49(1):90-94.  https://doi.org/10.1016/j.ejvs.2014.10.013
  5. Gavrilov SG, Moskalenko EP, Karalkin AV, Lebedev IS, Son DA, Turishcheva OO. Can the Diameter of Pelvic Veins be a Predictor of Pelvic Congestion Syndrome? Flebologiya. 2017;11(1):28-31. (In Russ.). https://doi.org/10.17116/flebo201711128-31
  6. Laborda A, Medrano J, de Blas I, Urtiaga I, Carnevale FC, de Gregorio MA. Endovascular treatment of pelvic congestion syndrome: visual analog scale (VAS) long-term follow-up clinical evaluation in 202 patients. Cardiovasc Intervent Radiol. 2013;36:1006-1014. https://doi.org/10.1007/s00270-013-0586-2
  7. Borghi C, Dell’Atti L. Pelvic congestion syndrome: the current state of the literature. Arch Gynecol Obstet. 2016;293(2):291-301.  https://doi.org/10.1007/s00404-015-3895-7
  8. Cheong YC, Smotra G, Williams AC. Non-surgical interventions for the management of chronic pelvic pain. Cochrane Database Syst Rev. 2014;3:CD008797. https://doi.org/10.1002/14651858.CD008797.pub2
  9. Danziger N. Pathophysiology of pain in venous disease. J Mal Vasc. 2007;32(1):1-7.  https://doi.org/10.1016/j.jmv.2006.10.001
  10. Wall and Melzack’s Textbook of Pain. 5th ed. Ed. by McMahon S.B., Koltzenburg M. Elsevier Churchill Livingstone. 2005;1239. https://doi.org/10.1016/B978-0-443-07201-7.X5001-2
  11. Omoigui S. The biochemical origin of pain: the origin of all pain is inflammation and the inflammatory response. Part 2 of 3 — inflammatory profile of pain syndromes. Med Hypotheses. 2007;69(6):1169-1178. https://doi.org/10.1016/j.mehy.2007.06.033
  12. Dinakar P, Stillman AM. Pathogenesis of Pain. Semin Pediatr Neurol. 2016;23(3):201-208.  https://doi.org/10.1016/j.spen.2016.10.003
  13. Webb DJ. Endogenous endothelin generation maintains vascular tone in humans. J Hum Hypertens. 1995;9(6):459-463. 
  14. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332(6163):411-415  https://doi.org/10.1038/332411a0
  15. Agu O, Hamilton G, Baker DM, Dashwood MR. Endothelin receptors in the aetiology and pathophysiology of varicose veins. Eur J Vasc Endovasc Surg. 2002;23(2):165-171.  https://doi.org/10.1053/ejvs.2001.1569
  16. Yang L, Qi GY, Cao YX, Liu J, Zhao M. The relationship between endothelin receptors and chronic venous insufficiency of lower extremities. Zhonghua Wai Ke Za Zhi. 2008;46(17):1325-1328. https://doi.org/10.3321/j.issn:0529-5815.2008.17.012
  17. Gyftopoulos K, Chondrogianni C, Papadaki H. Increased expression of endothelin-1 and its receptors in varicocele: an immunohistochemical study. Fertil Steril. 2011;95(8):2554-6.e1-2.  https://doi.org/10.1016/j.fertnstert.2011.04.062
  18. Pietrzycka A, Kózka M, Urbanek T, Stpniewski M, Kucharzewski M. Effect of Micronized Purified Flavonoid Fraction Therapy on Endothelin-1 and TNF-α Levels in Relation to Antioxidant Enzyme Balance in the Peripheral Blood of Women with Varicose Veins. Curr Vasc Pharmacol. 2015;13(6):801-808.  https://doi.org/10.2174/1570161113666150827124714
  19. Rosenfeld MG, Mermod JJ, Amara SG, Swanson LW, Sawchenko PE, Rivier J, Vale WW, Evans RM. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature. 1983;304(5922):129-135.  https://doi.org/10.1038/304129a0
  20. Brain SD, Grant AD. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev. 2004;84(3):903-934.  https://doi.org/10.1152/physrev.00037.2003
  21. Aubdool AA, Kodji X, Brain SD. Calcitonin Gene-Related Peptide (CGRP). Reference Module in Biomedical Sciences. Elsevier. 2017. https://doi.org/10.1016/B978-0-12-801238-3.95757-X
  22. Aubdool AA, Kodji X, Brain SD. Calcitonin Gene-Related Peptide (CGRP). Encyclopedia of Endocrine Diseases (Second Edition). 2017;4:204-212.  https://doi.org/10.1016/B978-0-12-801238-3.95757-X
  23. Raddant AC, Russo AF. Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation. Expert Rev Mol Med. 2011;13:e36.  https://doi.org/10.1017/S1462399411002067
  24. Stones RW, Thomas DC, Beard RW. Suprasensitivity to calcitonin gene-related peptide but not vasoactive intestinal peptide in women with chronic pelvic pain. Clin Auton Res. 1992;2(5):343-348.  https://doi.org/10.1007/BF01824305
  25. Stones RW. Chronic Pain in Women: New Perspectives on Pathophysiology and Management. Reproductive Medicine Review. Cambridge University Press. 2000;8(3):229-240. 
  26. Shawket S, Dickerson C, Hazleman B, Brown MJ. Selective suprasensitivity to calcitonin gene-related peptide in the hands in Raynaud’s phenomenon. Lancet. 1989;(334)8676:1354-1357. https://doi.org/10.1016/S0140-6736(89)91966-1
  27. Smillie S-J, Brain SD. Calcitonin gene-related peptide (CGRP) and its role in hypertension. Neuropeptides. 2011;45:93-104.  https://doi.org/10.1016/j.npep.2010.12.002
  28. Kee Z, Kodji X, Brain SD. The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects. Front Physiol. 2018;9:1249. https://doi.org/10.3389/fphys.2018.01249
  29. Qiao LY, Grider JR. Up-regulation of calcitonin gene-related peptide and receptor tyrosine kinase TrkB in rat bladder afferent neurons following TNBS colitis. Exp Neurol. 2007;204(2):667-679.  https://doi.org/10.1016/j.expneurol.2006.12.024
  30. Pan XQ, Gonzalez JA, Chang S, Chacko S, Wein AJ, Malykhina AP. Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways. Exp Neurol. 2010;225(2):262-273.  https://doi.org/10.1016/j.expneurol.2010.05.012
  31. Mistrova E, Kruzliak P, Chottova-Dvorakova M. Role of substance P in the cardiovascular system. Neuropeptides. 2016;58:41-51.  https://doi.org/10.1016/j.npep.2015.12.005
  32. Abdala AP, Haibara AS, Colombari E. Cardiovascular responses to substance P in the nucleus tractus solitarii: microinjection study in conscious rats. Am J Physiol Heart Circ Physiol. 2003;285(2):891-898.  https://doi.org/10.1152/ajpheart.00869.2002
  33. Hökfelt T, Elfvin LG, Schultzberg M, Goldstein M, Nilsson G. On the occurrence of substance P-containing fibers in sympathetic ganglia: immunohistochemical evidence. Brain Res. 1977;132(1):29-41.  https://doi.org/10.1016/0006-8993(77)90704-1
  34. Stones RW, Loesch A, Beard RW, Burnstock G. Substance P: endothelial localization and pharmacology in the human ovarian vein. Obstet Gynecol. 1995;85(2):273-278.  https://doi.org/10.1016/0029-7844(94)00368-N
  35. Origoni M, Leone Roberti Maggiore U, Salvatore S, Candiani M. Neurobiological mechanisms of pelvic pain. Biomed Res Int. 2014;2014:903848. https://doi.org/10.1155/2014/903848
  36. Mitsikostas DD, Reuter U. Calcitonin gene-related peptide monoclonal antibodies for migraine prevention: comparisons across randomized controlled studies. Curr Opin Neurol. 2017;30(3):272-280.  https://doi.org/10.1097/WCO.0000000000000438
  37. Taskin O, Sahin L, Gavrilov SG, Lazarashvili Z. Medical treatment of pelvic congestion syndrome. Phlebolymphology. 2016;(23)3:146-153. 
  38. Gavrilov SG, Turischeva OO. Conservative treatment of pelvic congestion syndrome: indications and opportunities. Curr Med Res Opin. 2017;33(6):1099-1103. https://doi.org/10.1080/03007995.2017.1302414
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.