The study aims to examine the neurological complications of patients with type 1 diabetes treated with different methods of insulin therapy. Material and methods. Thirty-four patients, aged from 18 to 40 years, with diabetes mellitus type 1 receiving insulinotherapy, with a duration of the disease 14.25±9.25 years, have been examined. By the time of the study the patients of the first group have been treated with continuous subcutaneous insulin infusion therapy (CSII) for 4.5±1.5 years following 11.3±5.4 years of standard basal-bolus therapy; the patients of the second group have been treated with basal-bolus insulin therapy for 12.7±7.7 years. Results and conclusion. Neurological status and the presence of vegetative symptoms of the patients were assessed, following tests were performed: MMSE, MoCA, HADS, TSS, NSS, NDS. The results demonstrated that the patients from the group of CSII therapy have had less signs and symptoms of neuropathy, cognitive disorders and better emotional condition than the patients from the group of basal-bolus therapy.