Parameters of prosaccades and antisaccades as potential markers of anxiety disorders

Shalaginova I.G.; Vakoliuk I.A.; Ecina I.G.

doi:https://doi.org/10.17116/jnevro201611612161-67

Shalaginova I.G.

Immanuel Kant Baltic Federal University, Institute of Live System, Kaliningrad, Russia

Vakoliuk I.A.

Immanuel Kant Baltic Federal University, Institute of Live System, Kaliningrad, Russia

Ecina I.G.

Immanuel Kant Baltic Federal University, Institute of Live System, Kaliningrad, Russia

Parameters of prosaccades and antisaccades as potential markers of anxiety disorders

Authors:

Shalaginova I.G., Vakoliuk I.A., Ecina I.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12): 61‑67

DOI: 10.17116/jnevro201611612161-67

Read: 1661 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Shalaginova IG, Vakoliuk IA, Ecina IG. Parameters of prosaccades and antisaccades as potential markers of anxiety disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12):61‑67. (In Russ.)
https://doi.org/10.17116/jnevro201611612161-67

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Hysterical disorders in patients with hematological diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):71-78

Attention deficit hyperactivity disorder: pharmacotherapy in special situations. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10):59-65

Features of arterial hypertension in individuals with anxiety disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(11):44-51

Clinical stratification of psoriasis phenotypes considering neuroimmune markers and associated psycho-emotional disorders. Russian Journal of Clinical Dermatology and Venereology. 2026;(2):214-217

Abstract:

Objective. To evaluate the parameters of visually-induced saccades and antisaccades in drug-naïve patients with anxiety disorders. Material and methods. A sample consisted of 18 subjects, including 10 healthy people and 8 patients with the diagnosis of anxiety disorder (ICD-10 items F43.0, F41.0, F41.1, F42). The authors’ method of video-oculography was used to assess eye-movement reactions. Results and conclusion. An increase in latency of correct antisaccades (AS) and visually-induced saccades (VIS) in patients with anxiety disorders was found. The effectiveness of task performance did not differ compared to healthy controls. A decreased generation of predictive saccades was identified in the experimental group. Possible neurophysiological foundations of the saccadic dysfunctions are discussed.

Keywords:

anxiety disorders

saccades

visually-induced saccades

antisaccades

Authors:

Shalaginova I.G.

Immanuel Kant Baltic Federal University, Institute of Live System, Kaliningrad, Russia

Vakoliuk I.A.

Immanuel Kant Baltic Federal University, Institute of Live System, Kaliningrad, Russia

Ecina I.G.

Immanuel Kant Baltic Federal University, Institute of Live System, Kaliningrad, Russia

Close metadata

References:

Harris M, Reilly J, Thase M, Keshavan M, Sweeney J. Response suppression deficits in treatment-naïve first-episode patients with schizophrenia, psychotic bipolar disorder and psychotic major depression. Psychiatry Research. 2009;170(2-3):150-156. doi: 10.1016/j.psychres.2008.10.031
Gooding D, Basso M. The tell-tale tasks: A review of saccadic research in psychiatric patient populations. Brain and Cognition. 2008;68(3):371-390. doi: 10.1016/j.bandc.2008.08.024
Rommelse N, Van der Stigchel S, Sergeant J. A review on eye movement studies in childhood and adolescent psychiatry. Brain and Cognition. 2008;68(3):391-414. doi: 10.1016/j.bandc.2008.08.025
Bittencourt J, Velasques, Teixeira et al. Saccadic eye movement applications for psychiatric disorders. Neuropsychiatric Disease and Treatment. 2013;1393. doi: 10.2147/ndt.s45931
Spengler D, Trillenberg P, Sprenger A et al. Evidence from increased anticipation of predictive saccades for a dysfunction of fronto-striatal circuits in obsessive — compulsive disorder. Psychiatry Research. 2006;143(1):77-88. doi: 10.1016/j.psychres.2005.08.020
Picard H, Amado I, Bourdel M, Landgraf S, Olié J, Krebs M. Correlates between neurological soft signs and saccadic parameters in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2009;33(4):676-681. doi: 10.1016/j.pnpbp.2009.03.012
Grootens K, van Luijtelaar G, Buitelaar J, van der Laan A, Hummelen J, Verkes R. Inhibition errors in borderline personality disorder with psychotic-like symptoms. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2008;32(1):267-273. doi: 10.1016/j.pnpbp.2007.08.020
Syunyakov TS, Syunyakov SA, Dorofeeva OA. Biological foundations of anxiety vs drugs with anxiolytic effect. Psihiatrija i psihofarmakoterapija. 2011;13(6):9-15. (In Russ.).
Bar-Haim Y, Lamy D, Pergamin L, Bakermans-Kranenburg M, van IJzendoorn M. Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study. Psychological Bulletin. 2007;133(1):1-24. doi: 10.1037/0033-2909.133.1.1
Tien AY, Pearlson GD, Machlin SR, Bylsma FW, Hoehn-Saric R. Oculomotor performance in obsessive-compulsive disorder. American Journal of Psychiatry. 1992;149:641-646.
Rosenberg DR, Dick EL, O’Hearn K, Sweeney JA. Response-inhibition deficits in obsessive-compulsive disorder: An indicator of dysfunction in frontostriatal circuits. Journal of Psychiatry and Neuroscience. 1997;22:29-38.
Maruff P, Purcell R, Tyler P, Pantelis C, Currie J. Abnormalities of internally generated saccades in obsessive-compulsive disorder. Psychological Medicine. 1999;29:1377-1385.
Saslow M. Effects of сomponents of вisplacement-step stimuli upon latency for saccadic eye movement. J Opt Soc Am. 1967;57(8):1024. doi: 10.1364/josa.57.001024
Kubarko AI, Kubarko NP. Corrective saccades in patients with multiple sclerosis. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2008;108(6):47-51. (In Russ.).
van der Wee N, Hardeman H, Ramsey N et al. Saccadic abnormalities in psychotropic-naive obsessive—compulsive disorder without co-morbidity. Psychological Medicine. 2006;36(09):1321. doi: 10.1017/s0033291706007926
Kloft L, Kischkel E, Kathmann N, Reuter B. Evidence for a deficit in volitional action generation in patients with obsessive-compulsive disorder. Psychophysiology. 2010;48(6):755-761. doi: 10.1111/j.1469-8986.2010.01138.x
Derakshan N, Eysenck M. Anxiety, Processing Efficiency, and Cognitive Performance. European Psychologist. 2009;14(2):168-176. doi: 10.1027/1016-9040.14.2.168
Wieser M, Pauli P, Mühlberger A. Probing the attentional control theory in social anxiety: An emotional saccade task. Cognitive, Affective, & Behavioral Neuroscience. 2009;9(3):314-322. doi: 10.3758/cabn.9.3.314
Bell C, Bourke C, Colhoun H, Carter F, Frampton C, Porter R. The misclassification of facial expressions in generalised social phobia. Journal of Anxiety Disorders. 2011;25(2):278-283. doi: 10.1016/j.janxdis.2010.10.001
Ventre J, Zee D, Papageorgiou H, Reich S. Abnormalities of predictive saccades in hemi-parkinson's disease. Brain. 1992;115(4):1147-1165. doi: 10.1093/brain/115.4.1147
Broerse A, Crawford T, den Boer J. Parsing cognition in schizophrenia using saccadic eye movements: a selective overview. Neuropsychologia. 2001;39(7):742-756. doi: 10.1016/s0028-3932(00)00155-x
Nickoloff S, Radant A, Reichler R, Hommer D. Smooth pursuit and saccadic eye movements and neurological soft signs in obsessive-compulsive disorder. Psychiatry Research. 1991;38(2):173-185. doi: 10.1016/0165-1781(91)90042-n