Objective. To study clinical and psychological features of autonomic dysfunction in girls with impaired development of menstrual functions (algodismenorrhea type) and to assess the efficacy of noofen in the treatment of these disorders. Material and methods. Seventy-five women, aged 14—17 years, with algomenorrhea and manifestations of autonomic dysfunction were examined. Conventional neurological and psychological examinations, a 10-cm Visual Analogue Scale (VAS), the Multidimensional Fatigue Inventory (MFI-20), A.M. Vein questionnaire, Kerdo index, Spielberger—Khanin questionnaire were used. Patients were divided into two groups. Patients of the first group (n=45) received noofen in dosage 500 mg daily. Patients of the second group (n=30) received cyclic vitamin therapy (1 tablet from the 1st to the 14th day of the menstrual cycle and 2 tablets from the 14th to the 28th day). The duration of the study was 30 days. Results and conclusion. Girls with algodismenorrhea had various neurological complaints and autonomic disorders. They were characterized by higher anxiety and asthenia as well. The efficacy of noofen in treatment of this disease was shown.