Objectives. To study the degenerative and regenerative age-related changes in human hippocampus. Materials and methods. An immunohistochemical investigation of the hippocampus was carried out in 50 people, aged 25-89 years, who died for different reasons not connected with the cerebral injury or pathology. Expression of the following markers was determined: tau-protein, GFAP, CD105/endoglin, E-selectin, NCAM, Cdk2. Statistical analysis was performed with the program package Biostat. Results and conclusions. Gliogenesis and vasculogenesis processes were active in old and very old age. They may be conditioned by ischemic cerebral injuries and accompany the development of Alzheimer's disease.