The article is devoted to the study of psychoautonomic features of patients with essential hypertension stage 1. The authors present the results of the clinical and psychological examinations of 62 patients with this pathology. These results show an increase in the levels of state and trait anxiety, which confirms the leading role of the psycho-emotional sphere in the formation of hypertensive reactions. This study evaluated the efficacy of the drug adaptol usage during 8 weeks in daily dose 1500 mg divided into three parts in the treatment of this group of patients. The results clearly demonstrate the positive effect of adaptol on psychoautonomic adaptation of patients with essential hypertension stage 1.