To evaluate prospects of immunocorrection in the treatment of patients with supratentorial meningiomas, we studied blood serum levels of interleukins 2, 4, 6, 10, 17, interferons α, β, γ, heat shock proteins HSP60, HSP70 using ELISA. A study included 32 patients with supratentorial meningiomas in the presurgical period and a control group of 38 patients with lumbar disc hernias. We found the multidirectional changes in the cytokine profile that demonstrated the existence of immune imbalance in patients with meningiomas. There was the increase in the levels of β-interferon, HSP60, interleukin 6 with the simultaneous decrease in α- and γ-interferons levels. The imbalance of cytokines in patients with meningiomas can have a negative impact on a clinical picture of the disease and worsen results of surgical treatment of tumors. To prevent secondary infectious complications after surgery, we recommend to administer glucocorticoids to decrease levels of interleukin 6 and α-interferon in the presurgical period.