Effects of neyromidin and cerebrolysin on clinical and electrophysiological patterns of neurodynamic disorders during traumatic brain injury were studied. The study involved 50 patients, aged from 21 to 58 years, with mild craniocerebral injury in subacute period. Patients were stratified into two groups. Patients of the first group (n=25) were treated with the general drugs (vasoactive and nootropic preparations, vitamins) as well as with neyromidin in dosage of 15 mg intramuscularly 1 time a day during 10 days. The second group of patients (n=25) received both general treatment and 10 ml of cerebrolysin intravenously 1 time a day during 10 days. The whole investigation lasted for 20 days. Besides the standard neurological examination, the Hamilton anxiety rating scale (HARS), Multidimensional Fatigue Symptom Inventory-short form (MFSI-SH, general fatigue was assessed) and Kerdo index were administered. We have also evaluated somatosensory evoked potentials and performed magnetic diagnostics to calculate central motor conduction time. The analysis of the results suggests that the two investigated drugs have a beneficial effect on the neurodynamic disorders in case of the craniocerebral injury. Nevertheless, the impact of neyromidin was more apparent and valid throughout the whole study.