Herpes encephalitis makes up more than 20% of all viral encephalitises in countries with moderate climate. Over the period of 1971-2008, 112 inpatients with herpes encephalitis have been examined and treated. Outcomes were as follows: 90 (80%) patients recovered and 22 (20%) patients died. The diagnostic criteria were the relation with herpes simplex virus type I (HSV-1) by immunological and clinical data in the presence of clinical symptoms of viral encephalitis for recovered patients and clinical symptoms of acute encephalitis, morphological foci of necrosis in the brain, relation with HSV, the absence of other alternative diagnosis for dead patients. Based on the analysis of 112 patients, the authors present clinical symptoms of herpes encephalitis. The presentation is supported by 2 case reports.