Non-traumatic intracerebral hemorrhages of multiple localization are most often associated with coagulopathies, uncontrolled use of anticoagulants, vasculitis, thrombosis of venous sinuses, amyloid angiopathy, and other conditions. If secondary risk factors cannot be identified, such hemorrhages are regarded as primary multiple due to hypertension. Their pathogenesis is poorly studied, with most researchers suggesting a sequential rupture of blood vessels when the first hemorrhage contributes to developing another one through increasing intracranial and blood pressure. There are few observations of primary multiple intracerebral hemorrhages in scientific publications, so the optimal management of such patients is not defined. The article presents two clinical cases of patients with primary multiple hypertensive intracerebral hemorrhages, as well as a brief review of current publications on this issue.