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Troshneva A.Yu.

Russian Medical Academy for Continuous Professional Education

Ametov A.S.

Russian Medical Academy of Continuing Postgraduate Education

Parkinson’s disease and type 2 diabetes mellitus: interrelation of pathogenetic mechanisms and general therapeutic approaches

Authors:

Troshneva A.Yu., Ametov A.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(11‑2): 12‑18

DOI: 10.17116/jnevro202212211212

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Table of contents

PARKINSON’S DISEASE AND TYPE 2 DIABETES MELLITUS: INTERRELATION OF PATHOGENETIC MECHANISMS AND GENERAL THERAPEUTIC APPROACHES
PARKINSON’S DISEASE AND TYPE 2 DIABETES MELLITUS: INTERRELATION OF PATHOGENETIC MECHANISMS AND GENERAL THERAPEUTIC APPROACHES

To cite this article:

Troshneva AYu, Ametov AS. Parkinson’s disease and type 2 diabetes mellitus: interrelation of pathogenetic mechanisms and general therapeutic approaches. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(11‑2):12‑18. (In Russ.)
https://doi.org/10.17116/jnevro202212211212

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The review article discusses the epidemiological, clinical and pathophysiological aspects of the relationship between Parkinson’s disease (PD) and type 2 diabetes mellitus (DM2). DM2 increases the risk of PD, correlates with the rate of its progression and severity of motor and cognitive deficits. The key link in the pathogenesis of both diseases can be insulin resistance that occurs in peripheral tissues in DM2 and in the brain in PD. In this regard, the use of antidiabetic drugs as neuroprotective agents opens up the possibility of developing a new strategy for targeted therapy that modifies the course of PD.

Keywords:

Parkinson’s disease
diabetes mellitus
insulin resistance
neurodegeneration

Authors:

Troshneva A.Yu.

Russian Medical Academy for Continuous Professional Education

Ametov A.S.

Russian Medical Academy of Continuing Postgraduate Education

Received:

22.07.2022

Accepted:

23.07.2022

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