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Cherkasov N.S.

Mental Health Research Centre

Kolykhalov I.V.

Mental Health Research Center

Non-cognitive psychopathological symptoms in mild cognitive impairment

Authors:

Cherkasov N.S., Kolykhalov I.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(10‑2): 41‑51

DOI: 10.17116/jnevro202112110241

Read: 3555 times

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Table of contents

NON-COGNITIVE PSYCHOPATHOLOGICAL SYMPTOMS IN MILD COGNITIVE IMPAIRMENT
NON-COGNITIVE PSYCHOPATHOLOGICAL SYMPTOMS IN MILD COGNITIVE IMPAIRMENT

To cite this article:

Cherkasov NS, Kolykhalov IV. Non-cognitive psychopathological symptoms in mild cognitive impairment. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(10‑2):41‑51. (In Russ.)
https://doi.org/10.17116/jnevro202112110241

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

Noncognitive psychopathological symptoms (NPS) in elderly patients are increasingly attracting the attention of researchers in the field of neurodegenerative diseases. The question is raised whether these symptoms are risk factors or initial manifestations of the neurodegeneration process. This article provides information on the prevalence of late-onset NPS together with mild cognitive impairment (MCI), combination of which reflects the risk of developing dementia. The characteristic of mild behavioral impairment syndrome, which is currently used along with the concept of MCI, is given. The authors summarized data of the studies published over the past 10 years on the effect of NPS on the progression of cognitive impairment. Topics related to the differential diagnosis of these disorders, as well as existing approaches to treatment, are considered.

Keywords:

geriatric psychiatry
neurodegenerative diseases
non-cognitive symptoms
mild cognitive impairments
mild behavioral impairment

Authors:

Cherkasov N.S.

Mental Health Research Centre

Kolykhalov I.V.

Mental Health Research Center

Received:

18.07.2021

Accepted:

16.08.2021

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References:

  1. Ataollahi Eshkoor S, Mun CY, Ng CK, Hamid TA. Mild cognitive impairment and its management in older people. Clin Interv Aging. Published online April 2015;687.  https://doi.org/10.2147/CIA.S73922
  2. Mallo SC, Ismail Z, Pereiro AX, et al. Assessing Mild Behavioral Impairment with the Mild Behavioral Impairment-Checklist in People with Mild Cognitive Impairment. J Alzheimers Dis. 2018;66(1):83-95.  https://doi.org/10.3233/JAD-180131
  3. Monastero R, Mangialasche F, Camarda C, Ercolani S, Camarda R. A Systematic Review of Neuropsychiatric Symptoms in Mild Cognitive Impairment. J Alzheimer’s Dis. 2009;18(1):11-30.  https://doi.org/10.3233/JAD-2009-1120
  4. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256(3):183-194.  https://doi.org/10.1111/j.1365-2796.2004.01388.x
  5. Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of Neuropsychiatric Symptoms in Dementia and Mild Cognitive Impairment. JAMA. 2002;288(12):1475. https://doi.org/10.1001/jama.288.12.1475
  6. Gavrilova SI, Fedorova YaB, Roshchina IF, Korovaitseva GI. Prognosis of the syndrome of mild cognitive impairment: the data of the biennial follow-up study. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2007;107(1):4-10. (In Russ.).
  7. Fischer CE, Ismail Z, Schweizer TA. Delusions Increase Functional Impairment in Alzheimer’s Disease. Dement Geriatr Cogn Disord. 2012;33(6):393-399.  https://doi.org/10.1159/000339954
  8. Karttunen K, Karppi P, Hiltunen A, et al. Neuropsychiatric symptoms and Quality of Life in patients with very mild and mild Alzheimer’s disease. Int J Geriatr Psychiatry. 2011;26(5):473-482.  https://doi.org/10.1002/gps.2550
  9. Balestreri L, Grossberg A, Grossberg GT. Behavioral and Psychological Symptoms of Dementia as a Risk Factor for Nursing Home Placement. Int Psychogeriatrics. 2000;12(S1):59-62.  https://doi.org/10.1017/S1041610200006773
  10. Fischer CE, Ismail Z, Schweizer TA. Impact of neuropsychiatric symptoms on caregiver burden in patients with Alzheimer’s disease. Neurodegener Dis Manag. 2012;2(3):269-277.  https://doi.org/10.2217/nmt.12.19
  11. Peters ME, Schwartz S, Han D, et al. Neuropsychiatric Symptoms as Predictors of Progression to Severe Alzheimer’s Dementia and Death: The Cache County Dementia Progression Study. Am J Psychiatry. 2015;172(5):460-465.  https://doi.org/10.1176/appi.ajp.2014.14040480
  12. Cerejeira J, Lagarto L, Mukaetova-Ladinska EB. Behavioral and Psychological Symptoms of Dementia. Front Neurol. 2012;3:23-29.  https://doi.org/10.3389/fneur.2012.00073
  13. Gavrilova SI. Pre-dementia neurocognitive disorder: diagnostic and therapeutic aspects. V.M. Bekhterev review of psychiatry and medical psychology. 2018;1:89-98. (In Russ.). https://www.bekhterevreview.com/jour/article/view/133/113
  14. Rozzini L, Vicini Chilovi B, Conti M, et al. Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment. Dement Geriatr Cogn Disord. 2008;25(1):32-36.  https://doi.org/10.1159/000111133
  15. Dotson VM, Beydoun MA, Zonderman AB. Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment. Neurology. 2010;75(1):27-34.  https://doi.org/10.1212/WNL.0b013e3181e62124
  16. Fernandez-Martínez M, Zarranz Imirizaldu JJ, Somme J, Salazar AM. P1-148: Neuropsychiatric symptoms in amnestic mild cognitive impairment: Increased risk and faster progression to dementia. Alzheimer’s Dement. 2011;7:159-159.  https://doi.org/10.1016/j.jalz.2011.05.428
  17. Caracciolo B, Bäckman L, Monastero R, Winblad B, Fratiglioni L. The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: A cohort study of a community dwelling elderly population. J Neurol Neurosurg Psychiatry. 2011;82(7):788-793.  https://doi.org/10.1136/jnnp.2010.225003
  18. Steenland K, Karnes C, Seals R, Carnevale C, Hermida A, Levey A. Late-life depression as a risk factor for mild cognitive impairment or alzheimer’s disease in 30 us alzheimer’s disease centers. Handb Depress Alzheimer’s Dis. 2015;31(2):69-80.  https://doi.org/10.3233/978-1-61499-542-5-69
  19. Mauri M, Sinforiani E, Zucchella C, Cuzzoni MG, Bono G. Progression to dementia in a population with amnestic mild cognitive impairment: Clinical variables associated with conversion. Funct Neurol. 2012;27(1):49-54. 
  20. Kim SH, Kang HS, Kim HJ, et al. Neuropsychiatric predictors of conversion to dementia both in patients with amnestic mild cognitive impairment and those with subcortical vascular MCI. Clin Neurol Neurosurg. 2013;115(8):1264-1270. https://doi.org/10.1016/j.clineuro.2012.11.029
  21. Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG. The Association of Neuropsychiatric Symptoms in MCI with Incident Dementia and Alzheimer Disease. Am J Geriatr Psychiatry. 2013;21(7):685-695.  https://doi.org/10.1016/j.jagp.2013.01.006
  22. Richard E, Reitz C, Honig LH, et al. Late-life depression, mild cognitive impairment, and dementia. JAMA Neurol. 2013;70(3):383-389.  https://doi.org/10.1001/jamaneurol.2013.603
  23. Somme J, Fernandez-MartÃnez M, Molano A, Jose Zarranz J. Neuropsychiatric Symptoms in Amnestic Mild Cognitive Impairment: Increased Risk and Faster Progression to Dementia. Curr Alzheimer Res. 2013;10(1):86-94.  https://doi.org/10.2174/156720513804871453
  24. Brodaty H, Connors MH, Ames D, Woodward M. Progression from mild cognitive impairment to dementia: A 3-year longitudinal study. Aust NZJ Psychiatry. 2014;48(12):1137-1142. https://doi.org/10.1177/0004867414536237
  25. Geda YE, Roberts RO, Mielke MM, et al. Baseline Neuropsychiatric Symptoms and the Risk of Incident Mild Cognitive Impairment: A Population-Based Study. Am J Psychiatry. 2014;171(5):572-581.  https://doi.org/10.1176/appi.ajp.2014.13060821
  26. Donovan NJ, Amariglio RE, Zoller AS, et al. Subjective Cognitive Concerns and Neuropsychiatric Predictors of Progression to the Early Clinical Stages of Alzheimer Disease. Am J Geriatr Psychiatry. 2014;22(12):1642-1651. https://doi.org/10.1016/j.jagp.2014.02.007
  27. Banks SJ, Raman R, He F, et al. The Alzheimer’s Disease Cooperative Study Prevention Instrument Project: Longitudinal Outcome of Behavioral Measures as Predictors of Cognitive Decline. Dement Geriatr Cogn Dis Extra. 2014;4(3):509-516.  https://doi.org/10.1159/000357775
  28. Forrester SN, Gallo JJ, Smith GS, Leoutsakos JMS. Patterns of neuropsychiatric symptoms in mild cognitive impairment and risk of dementia. Am J Geriatr Psychiatry. 2016;24(2):117-125.  https://doi.org/10.1016/j.jagp.2015.05.007
  29. Pink A, Stokin GB, Bartley MM, et al. Neuropsychiatric symptoms, APOE 4, and the risk of incident dementia: A population-based study. Neurology. 2015;84(9):935-943.  https://doi.org/10.1212/WNL.0000000000001307
  30. Osone A, Arai R, Hakamada R, Shimoda K. Cognitive and brain reserve in conversion and reversion in patients with mild cognitive impairment over 12 months of follow-up. J Clin Exp Neuropsychol. 2016;38(10):1084-1093. https://doi.org/10.1080/13803395.2016.1191620
  31. Blanco Martín E, Ugarriza Serrano I, Elcoroaristizabal Martín X, et al. Dysexecutive syndrome in amnesic mild cognitive impairment: A multicenter study. BMC Neurol. 2016;16(1):1-8.  https://doi.org/10.1186/s12883-016-0607-2
  32. Acosta I, Borges G, Aguirre-Hernandez R, Sosa AL, Prince M. Neuropsychiatric symptoms as risk factors of dementia in a Mexican population: A 10/66 Dementia Research Group study. Alzheimer’s Dement. 2018;14(3):271-279.  https://doi.org/10.1016/j.jalz.2017.08.015
  33. Bidzan M, Bidzan L, Bidzan-Bluma I. Neuropsychiatric symptoms and faster progression of cognitive impairments as predictors of risk of conversion of mild cognitive impairment to dementia. Arch Med Sci. 2017;13(5):1168-1177. https://doi.org/10.5114/aoms.2017.68943
  34. Gallucci M, Battista ME Di, Battistella G, Falcone C, Bisiacchi PS, Di Giorgi E. Neuropsychological tools to predict conversion from amnestic mild cognitive impairment to dementia. The TREDEM registry. Aging, Neuropsychol Cogn. 2018;25(4):550-560.  https://doi.org/10.1080/13825585.2017.1349869
  35. Kim JW, Byun MS, Sohn BK, et al. Clinical Dementia Rating Orientation Score as an Excellent Predictor of the Progression to Alzheimer’s Disease in Mild Cognitive Impairment. Psychiatry Investig. 2017;14(4):420.  https://doi.org/10.4306/pi.2017.14.4.420
  36. Burke SL, Cadet T, Alcide A, O’Driscoll J, Maramaldi P. Psychosocial risk factors and Alzheimer’s disease: the associative effect of depression, sleep disturbance, and anxiety. Aging Ment Heal. 2018;22(12):1577-1584. https://doi.org/10.1080/13607863.2017.1387760
  37. Kassem AM, Ganguli M, Yaffe K, Hanlon JT, Lopez OL, Wilson JW. Anxiety symptoms and risk of dementia and mild cognitive impairment in the oldest old women. Aging & Mental Health. Physiol Behav. 2017;22(4):474-482.  https://doi.org/10.1080/13607863.2016.1274370
  38. Taragano FE, Allegri RF, Heisecke SL, et al. Risk of Conversion to Dementia in a Mild Behavioral Impairment Group Compared to a Psychiatric Group and to a Mild Cognitive Impairment Group. J Alzheimer’s Dis. 2018;62(1):227-238.  https://doi.org/10.3233/JAD-170632
  39. Leoutsakos JS, Wise EA, Lyketsos CG, Smith GS. Trajectories of neuropsychiatric symptoms over time in healthy volunteers and risk of MCI and dementia. Int J Geriatr Psychiatry. 2019;34(12):1865-1873. https://doi.org/10.1002/gps.5203
  40. Ting C, Rajji TK, Ismail Z, et al. Differentiating the Cognitive Profile of Schizophrenia from That of Alzheimer Disease and Depression in Late Life. Hashimoto K, ed. PLoS One. 2010;5(4):e10151. https://doi.org/10.1371/journal.pone.0010151
  41. Jalal H, Ganesh A, Lau R, Lysack J, Ismail Z. Cholinesterase-inhibitor Associated Mania: A Case Report and Literature Review. Can J Neurol Sci/J Can des Sci Neurol. 2014;41(2):278-280.  https://doi.org/10.1017/S0317167100016735
  42. Ismail Z, Smith EE, Geda Y, et al. Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment. Alzheimer’s Dement. 2016;12(2):195-202.  https://doi.org/10.1016/j.jalz.2015.05.017
  43. Cummings J. The Role of Neuropsychiatric Symptoms in Research Diagnostic Criteria for Neurodegenerative Diseases. Am J Geriatr Psychiatry. Published online 2020;1-9.  https://doi.org/10.1016/j.jagp.2020.07.011
  44. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Arlington, VA: American Psychiatric Association, 2013. https://doi.org/10.1176/appi.books.9780890425596
  45. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s Dement. 2011;7(3):263-269.  https://doi.org/10.1016/j.jalz.2011.03.005
  46. Kørner A, Lopez AG, Lauritzen L, Andersen PK, Kessing LV. Acute and transient psychosis in old age and the subsequent risk of dementia: A nationwide register-based study. Geriatr Gerontol Int. 2009;9(1):62-68.  https://doi.org/10.1111/j.1447-0594.2009.00505.x
  47. Köhler S, Allardyce J, Verhey FRJ, et al. Cognitive Decline and Dementia Risk in Older Adults With Psychotic Symptoms: A Prospective Cohort Study. Am J Geriatr Psychiatry. 2013;21(2):119-128.  https://doi.org/10.1016/j.jagp.2012.10.010
  48. Masters MC, Morris JC, Roe CM. «Noncognitive» symptoms of early Alzheimer disease: A longitudinal analysis. Neurology. 2015;84(6):617-622.  https://doi.org/10.1212/WNL.0000000000001238
  49. Leoutsakos J-MS, Forrester SN, Lyketsos CG, Smith GS. Latent Classes of Neuropsychiatric Symptoms in NACC Controls and Conversion to Mild Cognitive Impairment or Dementia. J Alzheimer’s Dis. 2015;48(2):483-493.  https://doi.org/10.3233/JAD-150421
  50. Kantarci K, Weigand SD, Przybelski SA, et al. MRI and MRS predictors of mild cognitive impairment in a population-based sample. Neurology. 2013;81(2):126-133.  https://doi.org/10.1212/WNL.0b013e31829a3329
  51. Taragano FE, Allegri RF. Mild Behavioral Impairment: The Early Diagnosis. Int Psychogeriatr. Published online 2003;386. 
  52. Lyketsos CG. Neuropsychiatric symptoms of dementia: Nature and treatment. 9th Int Conf Alzheimer’s Dis Relat Disord. 2004; Philadelph.
  53. Taragano FE, Allegri RF, Lyketsos C. Mild behavioral impairment: A prodromal stage of dementia. Dement Neuropsychol. 2008;2(4):256-260.  https://doi.org/10.1590/S1980-57642009DN20400004
  54. Burhanullah MH, Tschanz JT, Peters ME, et al. Neuropsychiatric Symptoms as Risk Factors for Cognitive Decline in Clinically Normal Older Adults: The Cache County Study. Am J Geriatr Psychiatry. 2020;28(1):64-71.  https://doi.org/10.1016/j.jagp.2019.03.023
  55. Matsuoka T, Ismail Z, Narumoto J. Prevalence of Mild Behavioral Impairment and Risk of Dementia in a Psychiatric Outpatient Clinic. Abbate C, ed. J Alzheimer’s Dis. 2019;70(2):505-513.  https://doi.org/10.3233/JAD-190278
  56. Wise EA, Rosenberg PB, Lyketsos CG, Leoutsakos J. Time course of neuropsychiatric symptoms and cognitive diagnosis in National Alzheimer’s Coordinating Centers volunteers. Alzheimer’s Dement Diagnosis, Assess Dis Monit. 2019;11(1):333-339.  https://doi.org/10.1016/j.dadm.2019.02.006
  57. Creese B, Brooker H, Ismail Z, et al. Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults. Am J Geriatr Psychiatry. 2019;27(8):823-834.  https://doi.org/10.1016/j.jagp.2019.01.215
  58. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology. 1994;44(12):2308-2308. https://doi.org/10.1212/WNL.44.12.2308
  59. Ismail Z, Agüera-Ortiz L, Brodaty H, et al. The Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations. J Alzheimer’s Dis. 2017;56(3):929-938.  https://doi.org/10.3233/JAD-160979
  60. Mallo SC, Ismail Z, Pereiro AX, et al. Assessing mild behavioral impairment with the mild behavioral impairment checklist in people with subjective cognitive decline. Int Psychogeriatrics. 2019;31(2):231-239.  https://doi.org/10.1017/S1041610218000698
  61. Dillon C, Serrano, Castro, Heisecke, Taragano, Perez Leguizamon P. Behavioral symptoms related to cognitive impairment. Neuropsychiatr Dis Treat. Published online September 2013;1443. https://doi.org/10.2147/NDT.S47133
  62. Peters ME, Rosenberg PB, Steinberg M, et al. Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study. Am J Geriatr Psychiatry. 2013;21(11):1116-1124. https://doi.org/10.1016/j.jagp.2013.01.049
  63. Liew TM. Symptom Clusters of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Their Comparative Risks of Dementia: A Cohort Study of 8530 Older Persons. J Am Med Dir Assoc. 2019;20(8):1054.e1-1054.e9.  https://doi.org/10.1016/j.jamda.2019.02.012
  64. Canevelli M, Blasimme A, Vanacore N, Bruno G, Cesari M. Mild behavioral impairment: Ethical, methodological and clinical reflections. Neurosci Biobehav Rev. 2016;69:402-403.  https://doi.org/10.1016/j.neubiorev.2016.08.025
  65. Sultzer DL. Mild Behavioral Impairment: A New Domain of Late-Life Psychiatric Symptoms. Am J Geriatr Psychiatry. 2019;27(8):835-837.  https://doi.org/10.1016/j.jagp.2019.03.010
  66. Gatchel JR, Rabin JS, Buckley RF, et al. Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults. JAMA Netw Open. 2019;2(8):e198964. https://doi.org/10.1001/jamanetworkopen.2019.8964
  67. Orgeta V, Qazi A, Spector A, Orrell M. Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: Systematic review and meta-analysis. Br J Psychiatry. 2015;207(4):293-298.  https://doi.org/10.1192/bjp.bp.114.148130
  68. Holmes C, Wilkinson D, Dean C, Dean C, Vethanayagam S, Olivieri S, Langley A, Pandita-Gunawardena ND, Hogg F, Clare C, Damms J. The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease. Neurology. 2004;63:214-219.  https://doi.org/10.1212/01.wnl.0000129990.32253.7b
  69. Rodda J, Morgan S, Walker Z. Are cholinesterase inhibitors effective in the management of the behavioural and psychological symptoms of dementia in Alzheimer’s disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine. Int Psychogeriatr. 2009;21:813-824.  https://doi.org/10.1017/S1041610209990354
  70. Kolykhalov IV, Rassadina GA. Comparative evaluation of the effectiveness of inhibitors acetylcholinesterase in treatment of behavioral and psychotic disorders in in-patients with dementia. Psychiatry. 2009;1(37):51-56. (In Russ.).
  71. Courtney C, Farrell D, Gray R, et al. Long-term donepezil treatment in 565 patients with Alzheimer’s disease (AD2000): randomised double-blind trial. Lancet. 2004;363:2105-2115. https://doi.org/10.1016/S0140-6736(04)16499-4
  72. Rockwood K, Mintzer J, Truyen L, Wessel T, Wilkinson D. Effects of a flexible galantamine dose in Alzheimer’s disease: a randomised, controlled trial. J Neurol Neurosurg Psychiatry 2001;71:589-595.  https://doi.org/10.1136/jnnp.71.5.589
  73. Lu PH, Edland SD, Teng E, Tingus K, Petersen RC, Cummings JL, Alzheimer’s Disease Cooperative Study Group. Donepezil delays progression to AD in MCI subjects with depressive symptoms. Neurology. 2009;72(24):2115-2121. https://doi.org/10.1212/WNL.0b013e3181aa52d3
  74. Reynolds CF 3rd, Butters MA, Lopez O, Pollock BG, Dew MA, Mulsant BH, Lenze EJ, Holm M, Rogers JC, Mazumdar S, Houck PR, Begley A, Anderson S, Karp JF, Miller MD, Whyte EM, Stack J, Gildengers A, Szanto K, Bensasi S, Kaufer DI, Kamboh MI, DeKosky ST. Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy. Arch Gen Psychiatry. 2011;68(1):51-60.  https://doi.org/10.1001/archgenpsychiatry.2010.184
  75. Kolykhalov IV. Non-cognitive psychopathological symptoms as early manifestations of dementia: diagnostics and therapy. Pharmateca. 2018;367(14):52-58. (In Russ.). https://doi.org/10.18565/pharmateca.2018.14.52-58
  76. Gavrilova SI, Preuss UW, Wong JWM, Hoerr R, Kaschel R, Bachinskaya N. Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: A randomized, placebo-controlled, double-blind, multicenter trial. Int J Geriatr Psychiatry. 2014;29(10):1087-1095. https://doi.org/10.1002/gps.4103
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The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
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