Neurological status and structural changes in the tracheal lymphoid tissue in rats with different resistance to emotional stress of experimental hemorrhagic stroke

Klyueva L.A.; Koplik E.V.; Shvetsov E.V.; Vasyanina K.A.

doi:https://doi.org/10.17116/jnevro202012008245

Klyueva L.A.

Sechenov First Moscow State Medical University

Koplik E.V.

Anokhin Institute of Normal Physiology the Russian Academy Sciences

Shvetsov E.V.

Pirogov Russian National Research Medical University

Vasyanina K.A.

Sechenov First Moscow State Medical University

Neurological status and structural changes in the tracheal lymphoid tissue in rats with different resistance to emotional stress of experimental hemorrhagic stroke

Authors:

Klyueva L.A., Koplik E.V., Shvetsov E.V., Vasyanina K.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(8‑2): 45‑48

DOI: 10.17116/jnevro202012008245

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To cite this article:

Klyueva LA, Koplik EV, Shvetsov EV, Vasyanina KA. Neurological status and structural changes in the tracheal lymphoid tissue in rats with different resistance to emotional stress of experimental hemorrhagic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(8‑2):45‑48. (In Russ.)
https://doi.org/10.17116/jnevro202012008245

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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OBJECTIVE

To study neurological status and structural changes in the tracheal lymphoid tissue in rats with different resistance to emotional stress in experimental hemorrhagic stroke.

MATERIAL AND METHODS

Evaluation of neurological deficit on the Menzies scale and a histological study of structural features of tracheal lymphoid tissue were performed on days 1, 3 and 7 of experimental hemorrhagic stroke in 98 Wistar male rats with different resistance to emotional stress. Stroke simulation was preceded by animal testing to determine individual stress resistance.

RESULTS AND CONCLUSION

Neurological disorders are more pronounced in non-stress-resistant animals during all periods of observation. Lymphoid nodules of the tracheal wall of rats react with destruction of lymphoid cells and depletion of small lymphocytes observed in stress-resistant rats already on the 1^st day of a stroke. On the 3^rd day, the neurological deficit and changes in the cellular composition of the lymphoid formations of the trachea are most pronounced in both groups of rats. By the 7^th day, a positive trend towards the restoration of the structure of tracheal lymphoid tissue and normal neurological status is detected only in rats resistant to emotional stress.

Keywords:

stroke

neurological disorders

neurological deficit

lymphoid tissue

trachea

stress resistance

Authors:

Klyueva L.A.

Sechenov First Moscow State Medical University

Koplik E.V.

Anokhin Institute of Normal Physiology the Russian Academy Sciences

Shvetsov E.V.

Pirogov Russian National Research Medical University

Vasyanina K.A.

Sechenov First Moscow State Medical University

Received:

26.02.2019

Accepted:

05.03.2020

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References:

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