Features of the immune profile of schizophrenic patients with catatonic syndrome

Zakharova N.V.; Zozulya S.A.; Sarmanova Z.V.; Bravve L.V.; Otman I.N.; Klyushnik T.P.

doi:https://doi.org/10.17116/jnevro202012006246

Zakharova N.V.

Alekseev Moscow Psychiatric Hospital No. 1

Zozulya S.A.

Mental Health Research Center

ORCID: 0000-0001-5390-6007

Sarmanova Z.V.

Mental Health Research Centre

Bravve L.V.

Alekseev Moscow Psychiatric Hospital No. 1

Otman I.N.

Mental Health Research Centre

Klyushnik T.P.

Mental Health Research Center

ORCID: 0000-0001-5148-3864

Features of the immune profile of schizophrenic patients with catatonic syndrome

Authors:

Zakharova N.V., Zozulya S.A., Sarmanova Z.V., Bravve L.V., Otman I.N., Klyushnik T.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(6‑2): 46‑53

DOI: 10.17116/jnevro202012006246

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To cite this article:

Zakharova NV, Zozulya SA, Sarmanova ZV, Bravve LV, Otman IN, Klyushnik TP. Features of the immune profile of schizophrenic patients with catatonic syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(6‑2):46‑53. (In Russ.)
https://doi.org/10.17116/jnevro202012006246

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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OBJECTIVE

An analysis of inflammatory and autoimmune markers in schizophrenic patients with- and without catatonic symptoms in comparison to healthy controls.

MATERIAL AND METHODS

A sample of 170 patients with paranoid schizophrenia was stratified by the presence of catatonic symptoms in the structure of psychosis (66 patients with catatonia and 104 patients without catatonia), inclusion threshold was >10 points on the Bush—Francis catatonia scale. The examination was carried out in the early days of inpatient treatment using psychopathological, psychometric and immunological methods.

RESULTS

Quantitative and qualitative differences in the spectrum of immune indicators in both groups of patients are revealed. A higher level of the immune system activation is found in the group with catatonic symptoms that indicates a worsening of the pathological process. A specific feature of the immunological profile of catatonic syndrome in schizophrenia is a decrease in ratio between leukocyte elastase and a1-proteinase inhibitor (leukocyte-inhibitory index) accompanied by the increase of other inflammatory markers that, presumably, indicates the deterioration of the phagocyte component of the inflammatory response.

CONCLUSION

The results suggest that the decrease in leukocyte-inhibitory index is a potential biomarker of catatonic syndrome in schizophrenia.

Keywords:

catatonia

schizophrenia

neuro-immune-test

inflammatory and autoimmune markers

leukocyte-inhibitory index

Authors:

Zakharova N.V.

Alekseev Moscow Psychiatric Hospital No. 1

Zozulya S.A.

Mental Health Research Center

ORCID: 0000-0001-5390-6007

Sarmanova Z.V.

Mental Health Research Centre

Bravve L.V.

Alekseev Moscow Psychiatric Hospital No. 1

Otman I.N.

Mental Health Research Centre

Klyushnik T.P.

Mental Health Research Center

ORCID: 0000-0001-5148-3864

Received:

06.04.2020

Accepted:

13.04.2020

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