Clinical-epidemiological characteristics of multiple sclerosis and neuroopticomyelitis in the Central Asia

Khaybullin T.N.; Kirillova E.V.; Bikbaev R.M.; Boĭko A.N.

doi:https://doi.org/10.17116/jnevro20191192212

Khaybullin T.N.

Semey State Medical University, Semey, Kazahstan

Kirillova E.V.

Medical University of Semey, Semey, Kazakhstan

Bikbaev R.M.

Medical University of Semey, Semey, Kazakhstan

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Scopus AuthorID: 57224826008
ORCID: 0000-0001-6476-6417

Clinical-epidemiological characteristics of multiple sclerosis and neuroopticomyelitis in the Central Asia

Authors:

Khaybullin T.N., Kirillova E.V., Bikbaev R.M., Boĭko A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(2‑2): 12‑17

DOI: 10.17116/jnevro20191192212

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To cite this article:

Khaybullin TN, Kirillova EV, Bikbaev RM, Boĭko AN. Clinical-epidemiological characteristics of multiple sclerosis and neuroopticomyelitis in the Central Asia. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(2‑2):12‑17. (In Russ.)
https://doi.org/10.17116/jnevro20191192212

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

Objective. To study clinical-epidemiological characteristics of multiple sclerosis (MS) and neuroopticomyelitis spectrum diseases (NOMSD) in Semej town (Kazakhstan) taking into account ethnic identity. Material and methods. Epidemiological indicators and clinical characteristics of MS and NOMSD in Semej (the Central Asia region) were studied. Results and discussion. General MS prevalence was 10.1 per 100 000 population, 16.8 in Caucasians, 4.9 in Asians (OR=2.64; 95% CI 1.31—5.36). General female to male (F/M) ratio was 1:2.5, 1:1.2 in Asians; 1:5 in Caucasians. Mean age of patients and EDSS index at the time of observation were equal in both ethnic groups. Ten cases of NOMSD were found, all of them were recorded in the Asian population (prevalence 4.9 per 100 000 population). F/M was 1:9. Mean age (p=0.02) and age at disease onset (p=0.01), as well as EDSS indexes at time of onset and observation (p<0.001 and p<0.001) were higher in NOMSD patients compared to MS. No NOMSD cases were identified in Caucasians, while in Asians the equal prevalence of MS and NOMSD was shown. This finding may be explained by the presence of both Asian and Caucasian haplogroups in the Kazakh population.

Keywords:

multiple sclerosis

NOMSD

Central Asia

Kazakhs

aquaporin-4

Authors:

Khaybullin T.N.

Semey State Medical University, Semey, Kazahstan

Kirillova E.V.

Medical University of Semey, Semey, Kazakhstan

Bikbaev R.M.

Medical University of Semey, Semey, Kazakhstan

Boĭko A.N.

KGBUZ "Krasnoiarskiĭ kraevoĭ Tsentr po profilaktike i bor'be so SPID i infektsionnymi zabolevaniiami"

Scopus AuthorID: 57224826008
ORCID: 0000-0001-6476-6417

Close metadata

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