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Mkrtchyan V.R.

Z.P. Solovyov Research and Practical Psychoneurology Center, Moscow Healthcare Department, Moscow, Russia

Kaĭmovskiĭ I.L.

Gorodskaia klinicheskaia bol'nitsa # 12, Moskva

Pharmacoeconomic aspects of monotherapy of focal epilepsy

Authors:

Mkrtchyan V.R., Kaĭmovskiĭ I.L.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11‑2): 92‑98

DOI: 10.17116/jnevro201911911292

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To cite this article:

Mkrtchyan VR, Kaĭmovskiĭ IL. Pharmacoeconomic aspects of monotherapy of focal epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(11‑2):92‑98. (In Russ.)
https://doi.org/10.17116/jnevro201911911292

 
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Objective. To perform a clinical/economic comparison of monotherapy with antiepileptic drugs (AED) in patients with newly diagnosed focal epilepsy (FE) based on the results of previous studies. Material and methods. The most common AEDs (carbamazepine (CBZ), oxcarbazepine (OXZ), lamotrigine (LTG), lacosamide (LCM)) were compared in patients, aged 16 years and over, with illness duration of five years. Results and Conclusion. CBZ, OXZ and LCM can be used as monotherapy in patients with newly diagnosed FE. Monotherapy with LCM is associated with lowest costs for stopping focal seizures and the highest percentage of seizure-free patients. CBZ remains the most economical AED: the cost-effectiveness is minimal compared to all other AEDs used in the study. However, monotherapy with LCM is advisable if it is necessary to minimize side-effects in patients with newly diagnosed FE.

Keywords:

focal epilepsy
pharmacoeconomics
carbamazepine
oxcarbazepine
lamotrigine
lacosamide

Authors:

Mkrtchyan V.R.

Z.P. Solovyov Research and Practical Psychoneurology Center, Moscow Healthcare Department, Moscow, Russia

Kaĭmovskiĭ I.L.

Gorodskaia klinicheskaia bol'nitsa # 12, Moskva

List of references:

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