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Kimelfeld E.I.

Pirogov Russian National Research Medical University, Moscow, Russia

Kol'tsova E.A.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova, Moskva

Petrova E.A.

FGBU "NII onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Gudkova V.V.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova, Moskva

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Tupitsyna T.V.

Institute of Molecular Genetics of Russian Academy of Sciences, Moscow, Russia

Bondarenko E.A.

Institut molekuliarnoĭ genetiki Rossiĭskoĭ akademii nauk, Moskva

Slominskiĭ P.A.

Limborska S.A.

Institue of Molecular Genetics of Russian Academy of Sciences, 123182, Moscow, Russia

The association of hemostasis system genes with the development of ischemic stroke in patients under the age of 50 years

Authors:

Kimelfeld E.I., Kol'tsova E.A., Petrova E.A., Gudkova V.V., Stakhovskaya L.V., Tupitsyna T.V., Bondarenko E.A., Slominskiĭ P.A., Limborska S.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(9‑2): 14‑21

DOI: 10.17116/jnevro201811809214

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Table of contents

THE ASSOCIATION OF HEMOSTASIS SYSTEM GENES WITH THE DEVELOPMENT OF ISCHEMIC STROKE IN PATIENTS UNDER THE AGE OF 50 YEARS
THE ASSOCIATION OF HEMOSTASIS SYSTEM GENES WITH THE DEVELOPMENT OF ISCHEMIC STROKE IN PATIENTS UNDER THE AGE OF 50 YEARS

To cite this article:

Kimelfeld EI, Kol'tsova EA, Petrova EA, et al. The association of hemostasis system genes with the development of ischemic stroke in patients under the age of 50 years. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(9‑2):14‑21. (In Russ.)
https://doi.org/10.17116/jnevro201811809214

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

Objective. To study an influence of polymorphic variants of hemostasis system genes on the risk of ischemic stroke (IS) in patients of the Slavic population under the age of 50 years. Material and methods. Ninety-two patients (19 women and 73 men), aged 18—50 years, were examined. The diagnosis of stroke was confirmed by neuroimaging (CT or MRI) in all patients. Polymorphic alleles of GP1BA, F2, F5 were studied by a real-time polymerase chain reaction using the TaqMan technology. Results and conclusion. An analysis of the GP1BA -5T/C polymorphism showed that it was associated with IS in young men, lacunar stroke and stroke due to thrombosis of the brachiocephalic arteries. This association was not found in young women. The F5 G1691A polymorphism was associated with lacunar stroke. The F2 G20210A polymorphism was associated with stroke due to thrombosis of the brachiocephalic arteries.

Keywords:

stroke
young adults
gene polymorphism
GP1BA
F2
F5

Authors:

Kimelfeld E.I.

Pirogov Russian National Research Medical University, Moscow, Russia

Kol'tsova E.A.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova, Moskva

Petrova E.A.

FGBU "NII onkologii im. N.N. Petrova" Minzdrava Rossii, Sankt-Peterburg

Gudkova V.V.

Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova, Moskva

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Tupitsyna T.V.

Institute of Molecular Genetics of Russian Academy of Sciences, Moscow, Russia

Bondarenko E.A.

Institut molekuliarnoĭ genetiki Rossiĭskoĭ akademii nauk, Moskva

Slominskiĭ P.A.

Limborska S.A.

Institue of Molecular Genetics of Russian Academy of Sciences, 123182, Moscow, Russia

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