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Lebedeva I.S.

Meditsinskiĭ kholding "SM-Klinika"

Hatsenko I.E.

Morozov Children Clinical Hospital, Moscow, Russia

Sturov N.V.

Peoples Friendship University of Russia, Moscow, Russia

Guseva M.R.

Kafedra oftal'mologii pediatricheskogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Lobanova I.V.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Iaroslavskoĭ gosudarstvennoĭ meditsinskoĭ akademii, Iaroslavl'

Vykhristuik O.F.

Pirogov Russian National Research Medical University, Moscow, Russia

Kuhn Yu.A.

Morozov Children Clinical Hospital, Moscow, Russia

Tomyshev A.S.

Mental Health Research Center, Moscow, Russia

Cerebral structural characteristics in children with unilateral amblyopia: a MRI study

Authors:

Lebedeva I.S., Hatsenko I.E., Sturov N.V., Guseva M.R., Lobanova I.V., Vykhristuik O.F., Kuhn Yu.A., Tomyshev A.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(5‑2): 69‑74

DOI: 10.17116/jnevro20181185269

Views: 6977

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Table of contents

CEREBRAL STRUCTURAL CHARACTERISTICS IN CHILDREN WITH UNILATERAL AMBLYOPIA: A MRI STUDY
CEREBRAL STRUCTURAL CHARACTERISTICS IN CHILDREN WITH UNILATERAL AMBLYOPIA: A MRI STUDY

To cite this article:

Lebedeva IS, Hatsenko IE, Sturov NV, et al. . Cerebral structural characteristics in children with unilateral amblyopia: a MRI study. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(5‑2):69‑74. (In Russ.)
https://doi.org/10.17116/jnevro20181185269

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Objective. To study the mechanism of the development of amblyopia using the analysis of brain grey matter parameters. The areas primarily associated with visual cortex in children with amblyopia were analyzed. Material and methods. The study group comprised 8 right-handed children with left-sided amblyopia. MRI images were obtained by 1.5T Toshiba scanner with 3D MP-RAGE. T1-images were processed with FreeSurfer (5.3.0 version, http://surfer.nmr.mgh.harvard.edu/). Results and conclusion. No significant interhemisphere differences by cortical thickness were identified in all tested regions of interest. In correlation analysis, only the positive correlation between visual acuity in the left eye and cortical thickness in the left pericalcarine as well as the positive correlation between visual acuity in the left eye and cortical thickness in the left V1 area obtained using another anatomical atlas survived multiple comparison correction. The findings support the hypothesis that pathological ontogenetic processes in children with amblyopia lead to the structural abnormalities of the primary visual cortex.

Keywords:

amblyopia
MRI
grey matter
primary visual cortex

Authors:

Lebedeva I.S.

Meditsinskiĭ kholding "SM-Klinika"

Hatsenko I.E.

Morozov Children Clinical Hospital, Moscow, Russia

Sturov N.V.

Peoples Friendship University of Russia, Moscow, Russia

Guseva M.R.

Kafedra oftal'mologii pediatricheskogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Lobanova I.V.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Iaroslavskoĭ gosudarstvennoĭ meditsinskoĭ akademii, Iaroslavl'

Vykhristuik O.F.

Pirogov Russian National Research Medical University, Moscow, Russia

Kuhn Yu.A.

Morozov Children Clinical Hospital, Moscow, Russia

Tomyshev A.S.

Mental Health Research Center, Moscow, Russia

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