Early electrophysiological consequences of dosed traumatic-brain injury in rats

Komoltsev I.G.; Frankevich S.O.; Shirobokova N.I.; Volkova A.A.; Levshina I.P.; Novikova M.R.; Manolova A.O.; Guliaeva N.V.

doi:https://doi.org/10.17116/jnevro201811810221

Komoltsev I.G.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia;
Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russia

Frankevich S.O.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Shirobokova N.I.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Volkova A.A.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Levshina I.P.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Novikova M.R.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Manolova A.O.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Guliaeva N.V.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Early electrophysiological consequences of dosed traumatic-brain injury in rats

Authors:

Komoltsev I.G., Frankevich S.O., Shirobokova N.I., Volkova A.A., Levshina I.P., Novikova M.R., Manolova A.O., Guliaeva N.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(10‑2): 21‑26

DOI: 10.17116/jnevro201811810221

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To cite this article:

Komoltsev IG, Frankevich SO, Shirobokova NI, et al. Early electrophysiological consequences of dosed traumatic-brain injury in rats. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(10‑2):21‑26. (In Russ.)
https://doi.org/10.17116/jnevro201811810221

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

Objective. To analyze the pathological electrical activity during the acute period after traumatic brain injury (TBI) and to search for potential morphological correlates of this activity in the neocortex and hippocampus. Material and methods. The study was performed on male Sprague Dawley rats. TBI was modeled using a lateral hydrodynamic impact in the sensorimotor cortex area. ECoG was continuously recorded one week before and one week after TBI. A histological analysis was performed one week after TBI. Brain slices were Nissl stained as well as immunohistochemically stained for astrocytes (GFAP) and microglia (Isolectin B4). The damage to the neocortex and hippocampus was evaluated. Results and conclusion. The slowdown of the background activity one and six hours after TBI and appearance of epileptiform activity in a half of animals one week after TBI were shown. The number of discharges was correlated with the area of astrocyte gliosis in the neocortex and with the number of dark (ischemic-like) neurons in the hippocampus. Microglial activation did not correlate with the epileptiform activity. These data are important to understanding early mechanisms of post-trauma epileptogenesis.

Keywords:

traumatic brain injury

EEG

epileptiform activity

epileptogenesis

hippocampus

Authors:

Komoltsev I.G.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia;
Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russia

Frankevich S.O.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Shirobokova N.I.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Volkova A.A.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Levshina I.P.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Novikova M.R.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Manolova A.O.

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia

Guliaeva N.V.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

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