Characteristics of immune response and inflammatory reaction in atherothrombotic stroke and myocardial infarction

Konstantinova E.V.; Kochetov A.G.; Shostak N.A.; Shurdumova M.Kh.; Eremin I.I.; Lyang O.V.; Skvortsova V.I.

doi:https://doi.org/10.17116/jnevro201511512248-53

Konstantinova E.V.

Nauchno-issledovatel'skiĭ institut tserebrovaskuliarnoĭ patologii i insul'ta;
kafedra fundamental'noĭ i klinicheskoĭ nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Kochetov A.G.

Tsentr kardiokhirurgii i tsentr urologii 3-go Tsentral'nogo voennogo klinicheskogo gospitalia im. A.A. Vishnevskogo MO RF, Moskovskaia oblast', Krasnogorsk

Shostak N.A.

Kafedra fakul'tetskoĭ terapii im. akad. A.I. Nesterova lechebnogo fakul'teta Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Shurdumova M.Kh.

Eremin I.I.

Nauchno-issledovatel'skiĭ institut tserebrovaskuliarnoĭ patologii i insul'ta;
kafedra fundamental'noĭ i klinicheskoĭ nevrologii i neĭrokhirurgii;
kafedra éksperimental'noĭ i teoreticheskoĭ fiziki mediko-biologicheskogo fakul'teta;
kafedra fakul'tetskoĭ terapii im. A.I. Nesterova Rossiĭskogo gosudarstvennogo meditsinskogo universiteta;
spetsializirovannaia laboratoriia tsitologii, genetiki i immunologii Federal'nogo meditsinskogo biofizicheskogo tsentra im. A.I. Burnaziana, Moskva

Lyang O.V.

Assotsiatsija spetsialistov i organizatsij laboratornoj sluzhby «Federatsija laboratornoj meditsiny», 127083 Moskva, ul. 8 Marta, 1, str.12

Skvortsova V.I.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
NII tserebrovaskuliarnoĭ patologii i insul'ta, Moskva

Characteristics of immune response and inflammatory reaction in atherothrombotic stroke and myocardial infarction

Authors:

Konstantinova E.V., Kochetov A.G., Shostak N.A., Shurdumova M.Kh., Eremin I.I., Lyang O.V., Skvortsova V.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2015;115(12‑2): 48‑53

DOI: 10.17116/jnevro201511512248-53

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To cite this article:

Konstantinova EV, Kochetov AG, Shostak NA, Shurdumova MKh, Eremin II, Lyang OV, Skvortsova VI. Characteristics of immune response and inflammatory reaction in atherothrombotic stroke and myocardial infarction. S.S. Korsakov Journal of Neurology and Psychiatry. 2015;115(12‑2):48‑53. (In Russ.)
https://doi.org/10.17116/jnevro201511512248-53

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

Objective. To study characteristics of ischemic tissue damage basing on the assessment of the correlations between markers of immune response, inflammation and apoptosis in patients with myocardial infarction (MI) and atherothrombotic stroke (AS). Material and methods. Concentrations of matrix metalloproteinase-9 (MMP-9), immune complexes with cryogenic properties, soluble Fas-ligand, tumor necrosis factor alpha, interleukin-10 measured with ELISA as well as the activity of spontaneous apoptosis of mononuclear cells and surface expression of Toll-like receptors-4 and intracellular heat shock proteins measured with flow cytofluorometry were determined in the blood of 93 patients with the first AS and 94 patients with MI without concomitant inflammation in the 1st and 7th day of the disease. Results and conclusion. Increased levels of the markers of immune response, inflammation, apoptosis and destruction of the extracellular matrix were identified at the beginning of MI and AS. The results provide the evidence that similar mechanisms may be involved in ischemic tissue damage. Multivariate analysis conducterd by of principal component analysis correlation matrix revealed the specificity of the relationships between all of these markers. This is the completely new approach to assessin the role and importance of defined parameters in the acute period of the myocardial ischemia and brain.

Keywords:

ischemic stroke

myocardial infarction

immune response

inflammation

multifactor analysis