Blood concentrations of total cholesterol, β-lipoproteins, triglycerides and testosterone were studied in 73 men (mean age 65,9±8,6 years) with acute ischemic stroke. The concentrations of testosterone and triglycerides in men decrease with age and those of cholesterol and β-lipoproteins do not depend on the age. In middle-aged patients, the negative correlations were found between concentrations of testosterone and β-lipoproteins (r = –0,404; p<0,05); testosterone and cholesterol (r = –0,273; p<0,001). In elderly patients, there were negative correlations between concentrations of testosterone and triglycerides (r = –0,348; p<0,05). In middle-aged and elderly patients, concentrations of triglycerides and testosterone were negatively correlated (r = –0,478; p<0,001). The lower blood testosterone level was associated with the higher risk of the development of atherosclerotic lesions of major arteries that allowed to estimate risks of ischemic stroke in middle-aged and elderly men.