Background. The inflammatory process in the hepatobiliary system contributes to the development and progression of pathological changes in the adjacent digestive organs. The data available in the literature suggest that laser radiation and magnetic therapy are effective in treating hepatobiliary diseases. Objective. To evaluate the effects of magnetic laser radiation on the status of gastroduodenal organs in patients with chronic acalculous cholecystitis. Subjects and methods. Fifty patients with chronic acalculous cholecystitis, mostly women, were followed up; their mean age was 44±8 years (36 to 56 years); the disease duration was 6±1.5 years. The patients were randomized into 2 groups: 1) a comparison group (n=20) and 2) a study group (n=30). Both groups were homogeneous for sex, age, disease duration and severity. The basic treatment included the oral intake of Jermuk mineral water according to the generally accepted scheme, acupuncture, iodine-bromine baths, massage of the collar area, exercise therapy, and, if indicated, therapeutic enemas. During the basic treatment, the patients in the study group were prescribed magnetic laser radiation to the right subcostal area. Results were assessed at 20—22 days after treatment. Results. The performed treatment resulted in positive clinical changes and improvement in the indicators characterizing the status of gastroduodenal organs. Conclusion. The studies have established that rehabilitation in patients with chronic acalculous cholecystitis along with laser radiation contributes to positive clinical changes and improvement in the status of the gastroduodenal system. There is a tendency to normalize acid-forming function and morphological state of the gastric and duodenal mucosa.