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Reznik E.V.

Pirogov Russian National Research Medical University;
Savelyeva City Clinical Hospital No. 31

Guseva A.L.

Pirogov Russian National Research Medical University;
Pirogov City Clinical Hospital No. 1

Yasnovskaya A.A.

Pirogov Russian National Research Medical University

Nguyen T.L.

Pirogov Russian National Research Medical University

Mikhaleva L.M.

Savelyeva City Clinical Hospital No. 31;
Petrovsky Russian Scientific Center of Surgery — Avtsyn Research Institute of Human Morphology

Gioeva Z.V.

Petrovsky Russian Scientific Center of Surgery — Avtsyn Research Institute of Human Morphology

Baibakova E.V.

Sverzevsky Research Institute of Otorhinolaryngology

Smirnov A.P.

City Outpatient Clinic No. 212

Bilateral vestibulopathy and sensorineural hearing loss in necrobiotic xanthogranuloma, multiple myeloma and amiloidosis

Authors:

Reznik E.V., Guseva A.L., Yasnovskaya A.A., Nguyen T.L., Mikhaleva L.M., Gioeva Z.V., Baibakova E.V., Smirnov A.P.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2024;89(2): 82‑87

DOI: 10.17116/otorino20248902182

Read: 1584 times

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Table of contents

BILATERAL VESTIBULOPATHY AND SENSORINEURAL HEARING LOSS IN NECROBIOTIC XANTHOGRANULOMA, MULTIPLE MYELOMA AND AMILOIDOSIS
BILATERAL VESTIBULOPATHY AND SENSORINEURAL HEARING LOSS IN NECROBIOTIC XANTHOGRANULOMA, MULTIPLE MYELOMA AND AMILOIDOSIS

To cite this article:

Reznik EV, Guseva AL, Yasnovskaya AA, et al. . Bilateral vestibulopathy and sensorineural hearing loss in necrobiotic xanthogranuloma, multiple myeloma and amiloidosis. Russian Bulletin of Otorhinolaryngology. 2024;89(2):82‑87. (In Russ.)
https://doi.org/10.17116/otorino20248902182

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This article describes a rare case of necrotic xanthogranuloma in a 46-year-old patient who presented with the development of periorbital xanthelasms, progressive bilateral sensorineural hearing loss and bilateral vestibulopathy, followed by multiple myeloma and amyloidosis. For several years, the patient underwent standard rehabilitation for chronic sensorineural hearing loss and was fitted with a hearing aid. During hospitalisation for exacerbation of chronic bronchitis, monoclonal gammopathy was identified, and later, after careful examination and repeated biopsies, necrotic xanthogranuloma, multiple myeloma and AL-amyloidosis were confirmed. Targeted immunochemotherapy resulted in improvement of hearing and significant recovery of the vestibuloocular reflex bilaterally.

Keywords:

Monoclonal gammopathy
sensorineural hearing loss
bilateral vestibulopathy
AL amyloidosis
necrotic xanthogranuloma
multiple myeloma

Authors:

Reznik E.V.

Pirogov Russian National Research Medical University;
Savelyeva City Clinical Hospital No. 31

Guseva A.L.

Pirogov Russian National Research Medical University;
Pirogov City Clinical Hospital No. 1

Yasnovskaya A.A.

Pirogov Russian National Research Medical University

Nguyen T.L.

Pirogov Russian National Research Medical University

Mikhaleva L.M.

Savelyeva City Clinical Hospital No. 31;
Petrovsky Russian Scientific Center of Surgery — Avtsyn Research Institute of Human Morphology

Gioeva Z.V.

Petrovsky Russian Scientific Center of Surgery — Avtsyn Research Institute of Human Morphology

Baibakova E.V.

Sverzevsky Research Institute of Otorhinolaryngology

Smirnov A.P.

City Outpatient Clinic No. 212

Received:

22.12.2023

Accepted:

16.01.2024

Close metadata

References:

  1. Strupp M, Feil K, Dieterich M, Brandt T. Bilateral vestibulopathy. Handbook of Clinical Neurology. 2016;137:235-240.  https://doi.org/10.1016/B978-0-444-63437-5.00017-0
  2. Zhiznevskiy DV, Zamergrad MV, Levin OS, Azimova AA. Bilateral peripheral vestibulopathy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2023;123(4):24-30. (In Russ.). https://doi.org/10.17116/jnevro202312304124
  3. Kunel’skaya NL, Baybakova EV, Guseva AL, Chugunova MA, Kulakova EA. Etiology and clinical symptoms of bilateral vestibulopathy. Vestnik otorinolaringologii. 2020;85(3):32-35. (In Russ.). https://doi.org/10.17116/otorino20208503132
  4. Kossard S, Winkelmann RK. Necrobiotic xanthogranuloma with paraproteinemia. Journal of the American Academy of Dermatology. 1980;3:257-270. 
  5. Sorokina EV, Vladimirova EV, Akhmatova NK, Markova YuA. Differential diagnosis of granulomatous dermatoses without proven infectious agents. Klinicheskaya dermatologiya i venerologiya. 2021;20(6):19-29. (In Russ.). https://doi.org/10.17116/klinderma20212006119
  6. Miguel D, Lukacs J, Illing T, Elsner P. Treatment of necrobiotic xanthogranuloma — a systematic review. Journal of the European Academy of Dermatology and Venereology. 2017;31(2):221-235.  https://doi.org/10.1111/jdv.13786
  7. Inthasotti S, Wanitphakdeedecha R, Manonukul J. A 7-Year History of Necrobiotic Xanthogranuloma following Asymptomatic Multiple Myeloma: A Case Report. Dermatology Research and Practice. 2011;2011:927852. https://doi.org/10.1155/2011/927852
  8. Rose A, Robinson M, Kamino H, Latkowski JA. Necrobiotic xanthogranuloma. Dermatology Online Journal. 2012;18(12):30. 
  9. Wood AJ, Wagner MV, Abbott JJ, Gibson LE. Necrobiotic xanthogranuloma: A review of 17 cases with emphasis on clinical and pathologic correlation. Archives of Dermatology. 2009;145(3):279-284.  https://doi.org/10.1001/archdermatol.2008.583
  10. Reznik EV, Nguyen TL, Stepanova EA, Ustyuzhanin DV, Nikitin IG. Cardiac Amyloidosis: Internist and Cardiologist Insight. Arkhiv vnutrennej meditsiny. 2020;10(6):430-457. (In Russ.). https://doi.org/10.20514/2226-6704-2020-10-6-430-457
  11. Reznik EV, Nguyen TL, Ustyuzhanin DV, Semyachkina AN, Shkolnikova MA. Red flags to diagnose infiltrative cardiomyopathies. Rossijskij kardiologicheskij zhurnal. 2023;28(1S):5259. (In Russ.). https://doi.org/10.15829/1560-4071-2023-5259
  12. Flann S, Wain EM, Halpern S, Andrews V, Whittaker S. Necrobiotic xanthogranuloma with paraproteinaemia. Clinical and Experimental Dermatology. 2006;31(2):248-251.  https://doi.org/10.1111/j.1365-2230.2005.02042.x
  13. Zelger B, Eisendle K, Mensing C, Zelger B. Detection of spirochetal micro-organisms by focus-floating microscopy in necrobiotic xanthogranuloma. Journal of the American Academy of Dermatology. 2007;57(6):1026-1030. https://doi.org/10.1016/j.jaad.2007.05.016
  14. Szalat R, Pirault J, Fermand JP, Carrié A, Saint-Charles F, Olivier M, Robillard P, Frisdal E, Villard EF, Cathébras P, Bruckert E, Chapman MJ, Giral P, Guerin M, Lesnik P, Le Goff W. Physiopathology of necrobiotic xanthogranuloma with monoclonal gammopathy. Journal of Internal Medicine. 2014;276(3):269-284.  https://doi.org/10.1111/joim.12195
  15. Sánchez NB, Canedo IF, García-Patos PE, de Unamuno Pérez P, Benito AV, Pascual AM. Paraneoplastic vasculitis associated with multiple myeloma. Journal of the European Academy of Dermatology and Venereology. 2004;18(6):731-735.  https://doi.org/10.1111/j.1468-3083.2004.01069.x
  16. Keay D. Total bilateral hearing loss as a complication of myeloma. The Journal of Laryngology and Otology. 1988;102(4):357-358.  https://doi.org/10.1017/s0022215100104955
  17. Karimi K, Chheda NN. Nasopharyngeal amyloidosis: A case report. Laryngoscope. 2010;120(Suppl 4):S197. https://doi.org/10.1002/lary.21664
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