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Krukov A.I.
Sverzhevsky Moscow Scientific and Practical Othorhinolaryngology Center, Moscow
Kunel’skaya N.L.
N.I. Pirogov Russian National Research Medical University, Moscow, Russia, 117997;
L.I. Sverzhevsky Moscow Research and Practical Centre of Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152
Shershunova E.A.
The Institute for Electrophysics and Electric Power of the Russian Academy of Sciences, Saint-Petersburg, Russia, 191186
Rebrov I.E.
The Institute for Electrophysics and Electric Power of the Russian Academy of Sciences, Saint-Petersburg, Russia, 191186
Yamshchikov V.A.
The Institute for Electrophysics and Electric Power of the Russian Academy of Sciences, Saint-Petersburg, Russia, 191186
Garov E.V.
Moskovskiĭ nauchno-prakticheskiĭ tsentr otorinolaringologii Departamenta zdravookhraneniia Moskvy
Tsarapkin G.Yu.
Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russia
Mishchenko V.V.
L.I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152
Topical drug administration to the inner ear. Modern state of the problem and development perspectives
Journal: Russian Bulletin of Otorhinolaryngology. 2019;84(5): 6‑14
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To cite this article:
Krukov AI, Kunel’skaya NL, Shershunova EA, et al. . Topical drug administration to the inner ear. Modern state of the problem and development perspectives. Russian Bulletin of Otorhinolaryngology.
2019;84(5):6‑14. (In Russ.)
https://doi.org/10.17116/otorino2019840516
The work assessed modern methods of drug delivery through biological barriers to the lesion, in particular, through the most studied — skin. The main advantages and disadvantages of the existing methods for the topical administration of drugs into the inner ear — intra-imperial and intra-labyrinth delivery are analyzed. A brief review of medicinal substances for topical administration to the inner ear, both widely used (for example, aminoglycosides, steroid drugs) and undergoing clinical trials, is given. An assessment is made of the prospects for the use of transmembrane drug delivery to the inner ear using an electric field, which has a combined electro-creative and iontophoretic effect.
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Authors:
Krukov A.I.
Sverzhevsky Moscow Scientific and Practical Othorhinolaryngology Center, Moscow
Kunel’skaya N.L.
N.I. Pirogov Russian National Research Medical University, Moscow, Russia, 117997;
L.I. Sverzhevsky Moscow Research and Practical Centre of Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152
Shershunova E.A.
The Institute for Electrophysics and Electric Power of the Russian Academy of Sciences, Saint-Petersburg, Russia, 191186
Rebrov I.E.
The Institute for Electrophysics and Electric Power of the Russian Academy of Sciences, Saint-Petersburg, Russia, 191186
Yamshchikov V.A.
The Institute for Electrophysics and Electric Power of the Russian Academy of Sciences, Saint-Petersburg, Russia, 191186
Garov E.V.
Moskovskiĭ nauchno-prakticheskiĭ tsentr otorinolaringologii Departamenta zdravookhraneniia Moskvy
Tsarapkin G.Yu.
Sverzhevskiy Otorhinolaryngology Healthcare Research Institute, Moscow Department of Healthcare, Moscow, Russia
Mishchenko V.V.
L.I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152
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