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Mazina N.K.

Kirov State Medical Academy, Kirov

Mazin P.V.

Kirov State medical Academy, Kirov, Russia

Khafiz'ianova R.Kh.

Kafedra farmakologii, kafedra khirurgicheskikh bolezneĭ #1 Kazanskogo gosudarstvennogo meditsinskogo universiteta;
Respublikanskaia klinicheskaia bol'nitsa, Kazan'

Cycloferon efficacy in treatment of upper respiratory tract infections: systematic review and meta-analysis

Authors:

Mazina N.K., Mazin P.V., Khafiz'ianova R.Kh.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2019;84(3): 82‑88

DOI: 10.17116/otorino20198403182

Views: 4534

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To cite this article:

Mazina NK, Mazin PV, Khafiz'ianova RKh. Cycloferon efficacy in treatment of upper respiratory tract infections: systematic review and meta-analysis. Russian Bulletin of Otorhinolaryngology. 2019;84(3):82‑88. (In Russ.)
https://doi.org/10.17116/otorino20198403182

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)
 
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Medical scientific sources about randomized clinical trials of Cycloferon were studied as a single plot of 531 articles. AIM was to get the generalized cycloferon efficacy’s assessment in comparison with basic therapies curing the otorhinolaryngologic diseases. Groups heterogeneity and responding parameters’ variability were estimated also. Comparison groups were symmetric enough to annihilate end-point variabilities, so the results’ interpretations were clear enough and vector of clinical effects was detectable. Comparison groups were integrated to increase statistical power of metaanalysis. In result, cycloferon additional administration in treatment of otorhinolaryngologic diseases added 25% to absolute and relative usefulness of medical intervention. Also cycloferon increased 3,5 times the chances of recovery and absence of recurrent exacerbation.

Keywords:

cycloferon
otorhinolaryngologic diseases
meta-analysis
chance ratio
end-points
heterogeneity analysis
sensitivity analysis

Authors:

Mazina N.K.

Kirov State Medical Academy, Kirov

Mazin P.V.

Kirov State medical Academy, Kirov, Russia

Khafiz'ianova R.Kh.

Kafedra farmakologii, kafedra khirurgicheskikh bolezneĭ #1 Kazanskogo gosudarstvennogo meditsinskogo universiteta;
Respublikanskaia klinicheskaia bol'nitsa, Kazan'

List of references:

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  2. Demchenko EV, Romantzov MG, Grigoryan SS, Kovalenko AL. Cycloferon in complex medicaments management of chronic laryngitis. Antibiotiki i Chimioterapia. 2013;5-6:24-31. (In Russ.)
  3. Vasilenko IP, Romantzov MG, Kryukov AI, Grigorian SS, Kovalenko AL. Cycloferon as antirecurrence therapy drug in treatment of chronic hyperplastic sinusitis. Antibiotiki i Chimioterapia. 2013;7-8:17-22. (In Russ.)
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