The objective of the present study was to compare the effectiveness of two methods (transtympanic and intravenous) administration of steroids and standard therapy for the treatment of the patients presenting with acute sensorineural hearing impairment (OSNHI). Materials and methods: The study included 56 patients with this pathology. 18 of them were given transtympanic injections of steroids; 10 others received steroids intravenously in the combination with standard therapy. 28 patients were treated by the standard therapy alone. The effectiveness of the treatment was estimated by means of tonal threshold audiometry. Results: None of the patients in the first group enjoined total normalization of hearing. Its improvement by 10-29 dB was documented in 22 (78.6%) patients. In the second group hearing improved by 15-20 dB in 4 (40%) and by 5-10 dB in 6 (60%) patients. In the third group, 14 (77.7%) patients reported improvement of hearing and reduced noise as early as the first puncture. By the time of discharge from the hospital, their hearing improved by 30-40 dB while the 15-20 dB improvement was documented in 2 (11.1%) patients and the 5-10 dB improvement in another 2 (11.1%) patients. The study has demonstrated the high effectiveness of glucocorticoid therapy especially in the case of transtympanic administration of these steroids.