The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Malyugin B.E.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Geliastanov A.M.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”

Antonova O.P.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”

Andreeva E.A.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Poletaeva M.V.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”

Isabekov R.S.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”

Outcomes of hemi-Descemet membrane endothelial keratoplasty and phacoemulsification for the treatment of primary Fuchs’ endothelial corneal dystrophy combined with cataract

Authors:

Malyugin B.E., Geliastanov A.M., Antonova O.P., Andreeva E.A., Poletaeva M.V., Isabekov R.S.

More about the authors

Journal: Russian Annals of Ophthalmology. 2024;140(1): 36‑44

DOI: 10.17116/oftalma202414001136

Read: 1745 times

Download PDF (RU)
Contact the author
Table of contents

OUTCOMES OF HEMI-DESCEMET MEMBRANE ENDOTHELIAL KERATOPLASTY AND PHACOEMULSIFICATION FOR THE TREATMENT OF PRIMARY FUCHS’ ENDOTHELIAL CORNEAL DYSTROPHY COMBINED WITH CATARACT
OUTCOMES OF HEMI-DESCEMET MEMBRANE ENDOTHELIAL KERATOPLASTY AND PHACOEMULSIFICATION FOR THE TREATMENT OF PRIMARY FUCHS’ ENDOTHELIAL CORNEAL DYSTROPHY COMBINED WITH CATARACT

To cite this article:

Malyugin BE, Geliastanov AM, Antonova OP, Andreeva EA, Poletaeva MV, Isabekov RS. Outcomes of hemi-Descemet membrane endothelial keratoplasty and phacoemulsification for the treatment of primary Fuchs’ endothelial corneal dystrophy combined with cataract. Russian Annals of Ophthalmology. 2024;140(1):36‑44. (In Russ.)
https://doi.org/10.17116/oftalma202414001136

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Method for obtaining a pre-Descemet’s stro­mal layer graft. Russian Annals of Ophthalmology. 2025;(5):82-86
Abstract:

PURPOSE

This study evaluates the long-term results of surgical treatment of patients with Fuchs’ endothelial corneal dystrophy and cataract.

MATERIAL AND METHODS

The study included 24 patients (24 eyes) with primary Fuchs’ endothelial corneal dystrophy and cataract, who underwent cataract phacoemulsification with IOL implantation and of Descemet’s membrane endothelial keratoplasty with a semicircular graft (hemi-DMEK). The effect of treatment was assessed by best corrected visual acuity (BCVA), central corneal thickness (CCT) and endothelial cell density (ECD).

RESULTS

In total, surgical treatment involved 14 donor corneas that were divided in half during the preparation and isolation of the Descemet’s membrane (DM). By month 12 after the surgery an increase in visual functions and graft transparency were observed in 23 patients (23 eyes) out of 24. Repeated keratoplasty was required in one case due to fibrosis of the posterior layers of recipient’s corneal stroma. At 12 months postoperatively, the study group showed an increase in BCVA from 0.16±0.1 to 0.75±20, a decrease in CCT from 650.9±4.5 μm to 519.6±43.9, and a decreased in ECD from 2850.5±84.7 cells/mm2 up to 1285.5±277.2 cells/mm2. Thus, the loss of endothelial cells at one year after surgery amounted to 54.9%.

CONCLUSIONS

The developed method for transplantation of a semicircular DM fragment provides a tissue-saving approach to endothelial keratoplasty, and considering the high percentage of transparent engraftment of grafts and complete visual rehabilitation, it can be recommended in the treatment of patients with cataract and Fuchs’ endothelial corneal dystrophy.

Keywords:

Fuchs’ endothelial corneal dystrophy
endothelial keratoplasty
corneal transplantation
Descemet’s membrane
corneal endothelium
corneal thickness

Authors:

Malyugin B.E.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Geliastanov A.M.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”

Antonova O.P.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”

Andreeva E.A.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Poletaeva M.V.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”

Isabekov R.S.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”

Received:

27.03.2022

Accepted:

12.07.2022

Close metadata

References:

  1. Gain P, Jullienne R, He Z, et al. Global Survey of Corneal Transplantation and Eye Banking. JAMA Ophthalmol. 2016;134(2):167-173.  https://doi.org/10.1001/jamaophthalmol.2015.4776
  2. Malyugin BE, Antonova OP, Skorodumova LO, Sharova EI, Selezneva OV, Danilenko SA, Kostryukova ES. The study of genetic markers associated with primary endothelial corneal dystrophy (Fuchs). Fyodorov Journal of Ophthalmic Surgery = Oftal’mokhirrgia. 2016;(4):44-50. (In Russ.). https://doi.org/10.25276/0235-4160-2016-4-44-50
  3. Trufanov SV, Salovarova EP, Malozhen SA, Bagh RZ. Fuchs endothelial corneal dystrophy. Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2017;133(6):106-112. (In Russ.). https://doi.org/10.17116/oftalma20171336106-112
  4. Skorodumova LO, Belodedova AV, Antonova OP, et al. CTG18.1 Expansion is the Best Classifier of Late-Onset Fuchs’ Corneal Dystrophy Among 10 Biomarkers in a Cohort From the European Part of Russia. Invest Ophthalmol Vis Sci. 2018;59(11):4748-4754. https://doi.org/10.1167/iovs.18-24590
  5. Ong HS, Ang M, Mehta J. Evolution of therapies for the corneal endothelium: past, present and future approaches. Br J Ophthalmol. 2021;105(4): 454-467.  https://doi.org/10.1136/bjophthalmol-2020-316149
  6. Singh R, Gupta N, Vanathi M, Tandon R. Corneal transplantation in the modern era. Indian J Med Res. 2019;150(1):7-22.  https://doi.org/10.4103/ijmr.IJMR_141_19
  7. Malyugin BE, Shilova NF, Antonova OP, Anisimova NS, Shormaz IN. Clinical and functional results following femtosecond laser-assisted DSEK versus microkeratome-assisted DSAEK surgeries. A comparative study. Fyodorov Journal of Ophthalmic Surgery = Oftal’mokhirrgia. 2019;(1):20-26. (In Russ.). https://doi.org/10.25276/0235-4160-2019-1-20-26
  8. Shilova NF, Livny E, Anisimova NS, Antonova OP, Malyugin BE. Refractive outcomes following cataract combined with lamellar keratoplasty: femtosecond-DSEK versus microkeratome-DSAEK. Int Ophthalmol. 2021; 41(2):639-647.  https://doi.org/10.1007/s10792-020-01619-7
  9. Shilova NF, Nahum Y, Adler A, et al. Comparative analysis of biomechanical parameters of the corneas following Descemet membrane endothelial keratoplasty and contralateral healthy corneas. Graefes Arch Clin Exp Ophthalmol. 2019;257(9):1925-1929. https://doi.org/10.1007/s00417-019-04387-y
  10. Malyugin BE, Shilova NF, Anisimova NS, Antonova OP. Transplantation of endothelium and Descemet’s membrane. Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2019;135(1):98-103. (In Russ.). https://doi.org/10.17116/oftalma201913501198
  11. Deng SX, Lee WB, Hammersmith KM, et al. Descemet Membrane Endothelial Keratoplasty: Safety and Outcomes: A Report by the American Academy of Ophthalmology. Ophthalmology. 2018;125(2):295-310.  https://doi.org/10.1016/j.ophtha.2017.08.015
  12. Melles GR, Ong TS, Ververs B, van der Wees J. Preliminary clinical results of Descemet membrane endothelial keratoplasty. Am J Ophthalmol. 2008; 145(2):222-227.  https://doi.org/10.1016/j.ajo.2007.09.021
  13. Lam FC, Baydoun L, Dirisamer M, Lie J, Dapena I, Melles GR. Hemi-Descemet membrane endothelial keratoplasty transplantation: a potential method for increasing the pool of endothelial graft tissue. JAMA Ophthalmol. 2014;132(12):1469-1473. https://doi.org/10.1001/jamaophthalmol.2014.3328
  14. Zygoura V, Baydoun L, Ham L, et al. Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK) for Fuchs endothelial corneal dystrophy: 6 months clinical outcome. Br J Ophthalmol. 2018;102(10):1425-1430. https://doi.org/10.1136/bjophthalmol-2017-311398
  15. Oganesyan OG, Makarov PV, Grdikanyan AA, Getadaryan VR, Milash SV. The Partial Transplantation Of Descemet’s Membrane With Endothelium (1/2 And 1/4 DMEK). Medical Journal of the Russian Federation = Rossiyskiy meditsinskiy zhurnal. 2018;24(2):78-82. (In Russ.). https://doi.org/10.18821/0869-2106-2018-24-2-78-82
  16. Birbal RS, Hsien S, Zygoura V, et al. Outcomes of Hemi-Descemet Membrane Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy. Cornea. 2018;37(7):854-858.  https://doi.org/10.1097/ICO.0000000000001578
  17. Gerber-Hollbach N, Parker J, Baydoun L, et al. Preliminary outcome of hemi-Descemet membrane endothelial keratoplasty for Fuchs endothelial dystrophy. Br J Ophthalmol. 2016;100(11):1564-1568. https://doi.org/10.1136/bjophthalmol-2015-307783
  18. Godinho JV, Mian SI. Update on Descemet membrane endothelial keratoplasty. Curr Opin Ophthalmol. 2019;30(4):271-274.  https://doi.org/10.1097/ICU.0000000000000577
  19. Lie JT, Lam FC, Groeneveld-van Beek EA, van der Wees J, Melles GR. Graft preparation for hemi-Descemet membrane endothelial keratoplasty (hemi-DMEK). Br J Ophthalmol. 2016;100(3):420-424.  https://doi.org/10.1136/bjophthalmol-2015-307335
  20. Lazaridis A, Fydanaki O, Giallouros E, et al. Recovery of Corneal Clarity After DMEK Followed by Rebubbling Versus Uneventful DMEK. Cornea. 2018;37(7):840-847.  https://doi.org/10.1097/ICO.0000000000001554
  21. Gerber-Hollbach N, Baydoun L, López EF, et al. Clinical Outcome of Rebubbling for Graft Detachment After Descemet Membrane Endothelial Keratoplasty. Cornea. 2017;36(7):771-776.  https://doi.org/10.1097/ICO.0000000000001220
  22. Miron A, Spinozzi D, Bruinsma M, et al. Asymmetrical endothelial cell migration from in vitro Quarter-Descemet membrane endothelial keratoplasty grafts. Acta Ophthalmol. 2018;96(8):828-833.  https://doi.org/10.1111/aos.13841
  23. Malyugin BE, Malyutina EA, Tonaeva KD, Borzenok SA, Ostrovskiy DS. Study of human cornea endothelial cells migration into iatrogenic defect zone in experiment ex vivo. Practical Medicine = Prakticheskaya meditsina. 2018; 16(5):151-157. (In Russ.). https://doi.org/10.32000/2072-1757-2018-16-5-151-157
  24. Lam FC, Baydoun L, Satué M, Dirisamer M, Ham L, Melles GR. One year outcome of hemi-Descemet membrane endothelial keratoplasty. Graefes Arch Clin Exp Ophthalmol. 2015;253(11):1955-1958. https://doi.org/10.1007/s00417-015-3097-9
  25. Melles GR, Ong TS, Ververs B, van der Wees J. Descemet membrane endothelial keratoplasty (DMEK). Cornea. 2006;25(8):987-990.  https://doi.org/10.1097/01.ico.0000248385.16896.34
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.