The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
I.A. Ronzina
Research Institute of Eye Diseases
Yu.K. Murakhovskaya
Krasnov Research Institute of Eye Diseases;
Sechenov First Moscow State Medical University
T.A. Nevinitsyna
Research Institute of Eye Diseases
M.S. Shmelkova
Krasnov Research Institute of Eye Diseases
P.G. Tsygankova
Bochkov Research Center for Medical Genetics
E.S. Gerasimidi
Institute of Mitoengineering of the Lomonosov Moscow State University
K.G. Lyamzaev
Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University
M.V. Skulachev
Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University
E.M. Karger
Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University
Electrophysiological and psychophysical studies in assessment of visual functions in patients with hereditary optic neuropathy
Journal: Russian Annals of Ophthalmology. 2022;138(2): 5‑14
Views: 1218
Downloaded: 24
To cite this article:
Sheremet NL, Ronzina IA, Andreeva NA, Zhorzholadze NV, Murakhovskaya YuK, Nevinitsyna TA, Shmelkova MS, Krylova TD, Tsygankova PG, Gerasimidi ES, Lyamzaev KG, Skulachev MV, Karger EM. Electrophysiological and psychophysical studies in assessment of visual functions in patients with hereditary optic neuropathy. Russian Annals of Ophthalmology.
2022;138(2):5‑14. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma20221380215
To study the capabilities of electrophysiological and psychophysical examination methods for assessment of the functional state of ganglion cells, retina and optic nerve in patients with hereditary optic neuropathy (HON).
The study included 60 patients (118 eyes) with a genetically confirmed diagnosis of HON. All study patients underwent visual field test (VFT), spectral optical coherence tomography (OCT), flash and pattern visual evoked potentials (VEP) (Flash-VEP, FVEP; Pattern-VEP, PVEP), photopic electroretinography with photonegative response (PhNR) registration and the color vision test. In 24 patients (46 eyes), these parameters were assessed before the start of treatment and one year later. The treatment involved the mitochondria-targeted antioxidant SkQ1 — plastoquinonyl-decyl-triphenylphosphonium bromide (PDTP) in the form of eye drops.
The main PVEP components for 1.0° and 0.3° were registered in 20% and in 14% of patient eyes with HON and high visual functions, respectively. After one year of PDTP use, a significant decrease in P100 peak latency was found only in the group with disease duration of ≤1.5 years as of the time of treatment start (p<0.05). Significant differences were observed in the PhNR amplitude (p<0.004) between patients of the main and the control groups, as well as in the PhNR amplitude between patients with visual acuity of ≤0.1 and ≥0.13 (p<0.01). Patients with high visual functions were found to have a correlation between the PhNR amplitude, GCC thickness and the global loss index (GLV).
Along with VFT, OCT and color vision tests, electrophysiological studies are one of the main methods of examining patients with HON. After one year of PDTP use, there was a significant decrease in the FVEP P2 peak latency in the group with a disease duration of ≤1.5 years as of the time of treatment start. The PhNR amplitude in patients with high visual functions was found to correlate with structural changes in the ganglion cell layer and the retinal nerve fiber layer.
Keywords:
Authors:
I.A. Ronzina
Research Institute of Eye Diseases
Yu.K. Murakhovskaya
Krasnov Research Institute of Eye Diseases;
Sechenov First Moscow State Medical University
T.A. Nevinitsyna
Research Institute of Eye Diseases
M.S. Shmelkova
Krasnov Research Institute of Eye Diseases
P.G. Tsygankova
Bochkov Research Center for Medical Genetics
E.S. Gerasimidi
Institute of Mitoengineering of the Lomonosov Moscow State University
K.G. Lyamzaev
Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University
M.V. Skulachev
Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University
E.M. Karger
Institute of Mitoengineering of the Lomonosov Moscow State University;
A.N. Belozersky Institute of Physico-Chemical Biology of the Lomonosov Moscow State University
Received:
25.05.2021
Accepted:
30.11.2021
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.