In modern ophthalmological practice, three types of adhesives are most often used: synthetic (cyanoacrylate), biological (fibrin), and polyethylene glycol. Cyanoacrylate adhesive is very strong and polymerizes quickly, however, is generally more toxic compared to other types of adhesives, especially if applied to highly vascularized tissues. It is also believed to have bacteriostatic activity and suppress progressive stroma lysis within the area of ulceration by inhibiting polymorphonuclear leukocytes that exhibit collagenolytic and proteolytic activity. The article presents a clinical case of effective use of Russian-made cyanoacrylate (sulfacrylate) adhesive for the treatment of corneal perforation in a patient with neurotrophic keratopathy. The use of polymer glue can be an effective, affordable, and safe alternative to other methods of urgent treatment of corneal perforations and deep ulcers, as shown by this case and literature data. Depending on the lesion location and prognosis for vision, the method can be used either independently or become a treatment stage before keratoplasty. The latter would enable delayed transplantation with lower risk of complications.