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Panova I.E.

St. Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Samkovich E.V.

Saint Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Melikhova M.V.

Saint Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Grigoreva N.N.

N.N. Burdenko National Medical Research Center of Neurosurgery

Indocyanine green angiography in the diagnostics of choroidal tumors

Authors:

Panova I.E., Samkovich E.V., Melikhova M.V., Grigoreva N.N.

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(5): 5‑13

DOI: 10.17116/oftalma20201360515

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Table of contents

INDOCYANINE GREEN ANGIOGRAPHY IN THE DIAGNOSTICS OF CHOROIDAL TUMORS
INDOCYANINE GREEN ANGIOGRAPHY IN THE DIAGNOSTICS OF CHOROIDAL TUMORS

To cite this article:

Panova IE, Samkovich EV, Melikhova MV, Grigoreva NN. Indocyanine green angiography in the diagnostics of choroidal tumors. Russian Annals of Ophthalmology. 2020;136(5):5‑13. (In Russ.)
https://doi.org/10.17116/oftalma20201360515

Подписка 2025-2 (Russian Annals of Ophthalmology)
 
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PURPOSE

To study the use of ultrasound color Doppler imaging and indocyanine green (ICG) angiography for identification of malignant vasculature of choroidal tumors.

MATERIAL AND METHODS

The study included 46 patients (46 eyes) with tumors of the choroid: 19 men and 26 women aged 22 to 89 years, average age 53.2±17.1 years. All patients underwent indocyanine green angiography and Doppler ultrasound imaging. At the time of examination, thickness of the tumors ranged from 1.1 mm to 3.0 mm, and the base diameter from 4.0 mm to 13.0 mm. Choroidal melanoma was diagnosed in 27 patients, choroidal nevus in 10, choroidal hemangioma in 5, and choroidal metastasis in 4 patients.

RESULTS

The results of indocyanine green angiography demonstrate that the pathological malignant vasculature was determined: nevi was diagnosed in 7 out of 10 patients, choroidal melanoma in 16 out of 27, metastasis in 2 out of 4, and hemangioma in none of the 5 patients. Pathological malignant vasculature was determined in most patients with choroidal melanoma (77.8%), in all patients with choroidal hemangioma and in 3 patients with choroidal metastases. Ultrasound imaging revealed malignant vasculature in 15 of 27 (56%) patients with choroidal melanoma, it could be identified in all patients with hemangioma in 2 patients and with choroidal metastases, and in none patients with choroidal nevi.

CONCLUSIONS

Indocyanine green angiography helps verify malignant vasculature in 77.8% of patients with small and medium sized choroidal melanomas. Angioarchitecture of choroidal tumors visualized with indocyanine green angiography is characterized by variability of patterns, which should be taken into account in the differential diagnosis of various pathological diseases.

Keywords:

indocyanine green angiography
choroidal tumors
choroidal melanoma
choroidal nevi
choroidal hemangioma
choroidal metastasis
Doppler ultrasound imaging

Authors:

Panova I.E.

St. Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Samkovich E.V.

Saint Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Melikhova M.V.

Saint Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Grigoreva N.N.

N.N. Burdenko National Medical Research Center of Neurosurgery

Received:

31.10.2019

Accepted:

26.12.2019

List of references:

  1. Brovkina AF. Oftal’moonkologiya. M.: Meditsina; 2002. (In Russ.).
  2. Brovkina AF. Differential diagnosis of choroidal melanoma. Oftal’mologicheskie vedomosti. 2008;1(4):68-76. (In Russ.).
  3. Brovkina AF, Panova IE, Saakyan SV. Ophthalmic oncology: new in the last two decades. Vestnik oftal’mologii. 2014;130(6):13-19. (In Russ.).
  4. Vazhenin AV, Panova IE. Izbrannye voprosy oftal’moonkologii. M.: Izd-vo RAMN; 2006 (In Russ.).
  5. Amiryan AG, Brovkina AF, Lelyuk VG. Angioarchitectonics of uveal melanomas. Oftal’mologiya. 2005;2(1):37-40. (In Russ.).
  6. Kat’kova EA. Ul’trazvukovaya diagnostika ob»emnykh protsessov organa zreniya. M.: OOO «Firma STROM»; 2002. (In Russ.).
  7. Lelyuk VG, Brovkina AF, Amiryan AG. Comprehensive ultrasound for uveal melanoma. Ekhografiya. 2004;5(2):166. (In Russ.).
  8. Yarovoi AA, Linnik LF, Semikova TS, Bulgakova ES. Small choroidal melanomas: features of the clinic and the choice of treatment method. Novoe v oftal’mologii. 2004;(2):28-37. (In Russ.).
  9. Wang ZY, Yang WL, Li DJ, Chen W, et al. Ultrasound diagnosis and differential diagnosis of medium and small choroidal melanomas. Chin J Ophthalmol. 2018;54(11):843-848.  https://doi.org/10.3760/cma.j.issn.0412-4081.2018.11.009
  10. Wolff-Korman PG, Kormann BA, Hasenfratz GC, et al. Duplex and color Doppler ultrasound in the differential diagnosis of choroidal tumor. Acta Ophthalmol. 1992;70(204):66-70. 
  11. Ziangirova GG, Likhvantseva VG. Opukholi sosudistogo trakta glaza. M.: Poslednee slovo; 2003. (In Russ.).
  12. Pal’tsev MA, Anichkov NM. Atlas patologii opukholei cheloveka. M.: Meditsina; 2005 (In Russ.).
  13. Shields CL, Shields JA, De Potter P. Patterns of indocyanine green videoangiography of choroidal tumours. Brit J Ophthalmol. 1995;79(3):237-245.  https://doi.org/10.1136/bjo.79.3.237
  14. Atmaca LS, Batioğlu F, Atmaca P. Fluorescein and indocyanine green videoangiography of choroidal melanomas. Jap J Ophthalmol. 1999;43(1):25-30.  https://doi.org/10.1016/S0021-5155(98)00059-8
  15. Andersen MVN, Scherfig E, Prause JU. Differential diagnosis of choroidal melanomas and naevi using scanner laser ophthalmoscopical indocyanine green angiography. Acta Ophthalmol Scand. 1995;73(5):453-456.  https://doi.org/10.1111/j.1600-0420.1995.tb00308.x
  16. Kubicka-Trzaska A, Starzycka M, Romanowska-Dixon B. Indocyanine green angiography in the diagnosis of small choroidal tumours. Ophthalmologica. 2002;216(5):316-319.  https://doi.org/10.1159/000066177
  17. Mueller AJ, Bartsch DU, Folberg R, Mehaffey MG, Boldt HC. Imaging the microvasculature of choroidal melanomas with confocal indocyanine green scanning laser ophthalmoscopy. Arch Ophthalmol. 1998;116(1):31-39.  https://doi.org/10.1001/archopht.116.1.31
  18. Shiraki K, Moriwaki M, Yanagihara N, Kohno T, Miki T. Indocyanine green angiograms of choroidal nevi: Comparison between confocal and nonconfocal scanning ophthalmoscope and fundus video camera. Jap J Ophthalmol. 2001;45(4):368-374.  https://doi.org/10.1016/S0021-5155(01)00362-8
  19. Yannuzzi L, Lawrence A. Indocyanine green angiography: a perspective on use in the clinical setting. Am J Ophthalmol. 2011;151(5):745-751.  https://doi.org/10.1016/j.ajo.2011.01.043
  20. Folberg R, Hendrix MJC, Maniotis AJ. Vasculogenic mimicry and tumor angiogenesis. Am J Pathol. 2000;156(2):361-381.  https://doi.org/10.1016/S0002-9440(10)64739-6
  21. Frenkel S, Barzel I, Levy J, Lin AY. Demonstrating circulation in vasculogenic mimicry patterns of uveal melanoma by confocal indocyanine green angiography. Eye. 2008;22(7):948.  https://doi.org/10.1038/sj.eye.6702783
  22. Shields JA. Diagnosis and management of intraocular tumors. St. Louis: CV Mosby; 1983. P. 279-321. 
  23. Arevalo JF. Retinal angiography and optical coherence tomography. Springer Science & Business Media; 2008.
  24. Samkovich EV, Melikhova MV, Panova IE. Possibilities of identification of the vascular network of pigmented choroidal tumors. Sovremennye tekhnologii v oftal’mologii: aktual’nye problemy oftal’mologii. 2019;29(4):223-227. (In Russ.).
  25. Shields CL, Furuta M, Berman EL, Zahler JD, et al. Choroidal nevus transformation into melanoma. Analysis of 2514 consecutive cases. Arch Ophthalmol. 2009;127(8):981-987.  https://doi.org/10.1001/archophthalmol.2009.151
  26. Mueller AJ, Freeman WR, Folberg R, Bartsch DU, et al. Evaluation of microvascularization pattern visibility in human choroidal melanomas: comparison of confocal fluorescein with indocyanine green angiography. Graefe’s Arch Clin Exper Ophthalmol. 1999;237(6):448-456.  https://doi.org/10.1007/s004170050260
  27. Folberg R, Chen X, Boldt HC, et al. Microcirculation patterns other than loops and networks in choroidal and ciliary body melanomas. Ophthalmology. 2001;108(5):996-1001. https://doi.org/10.1016/S0161-6420(01)00541-3

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