Combined laser treatment of glaucoma

Ryabtseva A.A.; Khomyakova E.N.; Sergushev S.G.

doi:https://doi.org/10.17116/oftalma202013604199

Ryabtseva A.A.

Moscow Regional Research and Clinical Institute (MONIKI)

Khomyakova E.N.

Moscow Regional Research and Clinical Institute (MONIKI)

Sergushev S.G.

Moscow Regional Research and Clinical Institute (MONIKI)

Combined laser treatment of glaucoma

Authors:

Ryabtseva A.A., Khomyakova E.N., Sergushev S.G.

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(4): 99‑104

DOI: 10.17116/oftalma202013604199

Read: 1636 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Ryabtseva AA, Khomyakova EN, Sergushev SG. Combined laser treatment of glaucoma. Russian Annals of Ophthalmology. 2020;136(4):99‑104. (In Russ.)
https://doi.org/10.17116/oftalma202013604199

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

Close metadata

PURPOSE

To study the effectiveness of non-penetrating hypotensive laser sclerotomy (NHLS) in patients with non-stabilized primary open-angle (I—III) b glaucoma with previous laser trabeculoplasty and who are receiving drug therapy.

MATERIAL AND METHODS

The study included 54 patients (102 eyes) with initial (38 eyes), developed (46 eyes) and advanced (18 eyes) glaucoma who were examined and operated on. 26 patients (46 eyes) were instilled a combined drug containing brinzolamide and timolol, 28 patients (56 eyes) received prostaglandin F2α analogues (PGA). Intraocular pressure (IOP) levels were 27±2.4 mm Hg.

RESULTS

Reduction of IOP was observed in 89% of patients 2 weeks after NHLS with gradual improvement during the first 3 months of the follow-up; in 71% of patients the results preserved by the 6^th month. Patients receiving combination of brinzolamide and timolol had more pronounced IOP reduction after NHLS amounting to 2.4±1.8 mm Hg in the first 3 months. By the end of the observation period IOP levels remained within normal range, drug therapy was ceased in 16 patients (21 eyes, 20.6%), 32 patients (67 eyes, 65.7%) achieved normalized intraocular pressure with antihypertensive therapy, and 9 patients (9 eyes, 8.8%) were referred to surgical treatment.

CONCLUSION

Non-penetrating hypotensive laser sclerotomy (NHLS) allows measured reduction of IOP in various glaucoma stages achieving controlled and persistent hypotensive effect. In the group of patients receiving combination of brinzolamide and timolol, the effect is statistically significant and clinically superior when compared with patients receiving PGA.

Keywords:

glaucoma

non-penetrating hypotensive laser sclerotomy

trabeculoplasty

prostaglandin F2α analogues

combined brinzolamide and timolol

Authors:

Ryabtseva A.A.

Moscow Regional Research and Clinical Institute (MONIKI)

Khomyakova E.N.

Moscow Regional Research and Clinical Institute (MONIKI)

Sergushev S.G.

Moscow Regional Research and Clinical Institute (MONIKI)

Received:

26.11.2018

Accepted:

19.03.2019

Close metadata

References:

Oftal’mologiya. Natsional’noe rukovodstvo. Pod red. Avetisova S.E., Egorova E.A., Moshetovoi L.K. M.: Geotar Media; 2008. (In Russ.).
Libman ES, Ryazanov DP, Kalyaeva EV. Invalidnost’ vsledstvie narusheniya zreniya v Rossii. 5 Rossiiskii obshchenatsional’nyi forum. Sbornik trudov. 2012;2:797-798. (In Russ.).
Mikrokhirurgicheskaya anatomiya drenazhnoi sistemy glaza. Zolotarev A.V. S.: Izdatel’stvo Samarskii Universitet; 2009. (In Russ.).
Mikrokhirurgiya glaukom. Pod red. Krasnova M.M. M.: Izdarel’stvo Meditsina; 1980. (In Russ.).
Glaukoma. Pod red. Nesterova A.P. M.: Izdatel’stvo Meditsina; 1995. (In Russ.).
Ul’trazvukovaya biomikroskopiya v diagnostike patologii perednego otrezka glaza. Pod red. Takhchidi Kh.P., Egorovoi E.V., Uzunyan D.G. M.: Izdatel’stvo FGU MNTK Mikrokhirurgiya glaza; 2007. (In Russ.).
Redkie formy glaukomy. Pod red. Shchuko A.G., Yur’evoi T.N., Chekmarevoi L.T., Malysheva V.V. I.: PR-STUDIYA; 2002. (In Russ.).
Glaznoe davlenie v norme i patologii. Kn. 1.: Anatomo-fiziologicheskie kharakteristiki. Pod red. Dronova M.M., Korovenkova R.I. SPb.: Izdatel’stvo Nestor Istoria; 2011. (In. Russ.).
Shmyreva VF. Novyi klinicheskii sposob izucheniya limfaticheskoi sistemy perednego segmenta glaznogo yabloka. Vestnik oftal’mologii. 1984;3:8-10. (In Russ.).
Grüntzig J, Hollman F. Lymphatic vessels of the eye — old questions — new insights. Annals of Anatomy. 2018;221:1-16. https://doi.org/10.1016/j.aanat.2018.08.004
Rol’ rigidnosti fibroznoi obolochki glaza i fluktuatsii sklery v rannei diagnostike glaukomy. Accessed 12.12.18. (In Russ.). https://organum-visus.ru/rigfibrob.zip
Arutyunyan LL. Influence of antihypertensive therapy on morphofunctional and biomechanical parameters of eyes. Vestnik oftal’mologii. 2015;5:61-67. (In Russ.). https://doi.org/10.17116/oftalma2015131561-67
Shi MJ, Jia SB. Selective laser trabeculoplasty. Int J Ophthalmology. 2012; 5(6):742-749. https://doi.org/10.3980/j.issn.2222-3959.2012.06.17
General Ophthalmology. Vaughan D, Asbury T, Riordan-Eva P. Stamford Appleton & Lange. 1983. https://doi.org/10.1097/00006324-198310000-00012
Natsional’noe rukovodstvo po glaukome (putevoditel’) dlya poliklinicheskikh vrachei. Pod red. Egorova E.A., Astakhova Yu.S., Schuko A.G. M.: Izdatel’stvo OOO Alcon farmatsevtika; 2008. (In Russ.).
Latina MA, Park CH. Selective targeting of trabecular meshwork cells: in vitro studies at pulsed and CW laser interactions. Exp Eye Res. 1995;60:359-371. https://doi.org/10.1016/s0014-4835(05)80093-4
Wise JB, Witter SL. Argon laser therapy for open-angle glaucoma. A pilot study. Arch Ophthalmol. 1979;97:319-322. https://doi.org/10.1001/archopht.1979.01020010165017
Latina MA, Sibavan SA, Shin DH, Noecker RJ. Q-switched 532-nm Nd: YAG laser trabeculoplasty (SLT): multicentral, pilot, clinical study. Ophthalmology. 1998;105(11):2-8. https://doi.org/10.1016/s0161-6420(98)91129-0
Saimsek T. Efficacy of argon laser trabeculoplasty in primary open-angle and pseudoexfoliative Glaucoma. Annals of Ophthalmology. 2001;33:216-220. https://doi.org/10.1007/s12009-001-0030-0
Ryabtseva AA, Sergushev SG, Khomyakova EN. Biomekhanicheskoe obosnovanie i effektivnost’ lazernoi nepronikayushchei gipotenzivnoi sklerotomii. Sbornik trudov nauchno-prakticheskoĭ konferentsii Fedorovskie chteniya. 2008;158-159. (In Russ.).
Ryabtseva AA, Sergushev SG, Khomyakova EN. Novyi podkhod k lazernomu lecheniyu diabeticheskoi neovaskulyarnoi glaukomy. Al’manakh klinicheskoi meditsiny. 2011;24:3-7. (In Russ.).