Unilateral multifocal uveal melanoma (a clinical and genetic study)

Saakian S.V.; Parmon Ya.V.; Tsygankov A.Iu.; Amirian A.G.; Burdennyy A.M.

doi:https://doi.org/10.17116/oftalma201813405178

Saakian S.V.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Parmon Ya.V.

Helmholtz Moscow Research Institute of Eye Diseases, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062

Tsygankov A.Iu.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Amirian A.G.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Burdennyy A.M.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

Unilateral multifocal uveal melanoma (a clinical and genetic study)

Authors:

Saakian S.V., Parmon Ya.V., Tsygankov A.Iu., Amirian A.G., Burdennyy A.M.

More about the authors

Journal: Russian Annals of Ophthalmology. 2018;134(5): 78‑85

DOI: 10.17116/oftalma201813405178

Read: 1277 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Saakian SV, Parmon YaV, Tsygankov AIu, Amirian AG, Burdennyy AM. Unilateral multifocal uveal melanoma (a clinical and genetic study). Russian Annals of Ophthalmology. 2018;134(5):78‑85. (In Russ.)
https://doi.org/10.17116/oftalma201813405178

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Uveal melanoma and its local inflammation — good or bad for the patient?. Russian Annals of Ophthalmology. 2025;(1):5-12

Post-radiation choroidal melanoma pathomorphosis assessment in clinical practice. Russian Journal of Archive of Pathology. 2025;(3):33-39

Remote results of treatment of patients with prostate cancer who underwent radiation therapy in a combined version. P.A. Herzen Journal of Oncology. 2025;(3):14-19

Abstract:

The study presents clinical and genetic analysis of a case of unilateral multifocal uveal choroidal melanoma in a patient of 67 years. Results of ophthalmoscopy, echography, fluorescent angiography, optical coherence tomography are described. Molecular genetic testing of peripheral blood samples was performed, including detection of the occurrences of CC genotype in C3435T polymorphism of the gene ABCB1/MDR1 associated with unfavorable vital prognosis. Analysis of the genes GNAQ and GNA11 revealed two mutually exclusive mutations in the genes GNAQG183A and GNAQA209C showing genetic heterogeneity of the two tumor lesions. Organ preservation treatment of unilateral multifocal uveal melanoma was proven possible with brachytherapy method. Uveal melanoma with multicentric growth is of interest to ophthalmologists because it requires differential diagnostics from a variety of diseases including metastases in the choroid, such as metastases of uveal melanoma and skin melanoma, as well as other intraocular neoplasms.

Keywords:

uveal melanoma

multifocal thin-needle aspiration biopsy

polymorphism of ABCB1 gene

mutations in GNAQ/GNA11 genes

brachytherapy

Authors:

Saakian S.V.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Parmon Ya.V.

Helmholtz Moscow Research Institute of Eye Diseases, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062

Tsygankov A.Iu.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Amirian A.G.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Burdennyy A.M.

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315

Close metadata

References:

Brovkina AF. Current aspects of treatment for choroidal melanomas: problems, controversial questions. Vestnik Oftal’mologii. 2006;122(1):13-15 (In Russ.)
Brovkina AF, Panova IE, Saakyan SV. Ophthalmic oncology: achievements over the last two decades. Vestnik Oftal’mologii. 2014;130(6):13-19.(In Russ.)
Filloy A, Caminal JM, Bruzual MC, Varela Mdel M, Gomà M. Cytogenetical study of a multifocal uveal melanoma. Semin Ophthalmol. 2014;29(3):163-165. https://doi.org/10.3109/08820538.2013.801496
Brovkina AF, Mezentseva GA. Bilateral uveal melanomas. Vestnik Oftal’mologii. 1984;100(2):31-33. (In Russ.)
Pe’er J, Bernstein-Lifshitz L. Case report: anterior and posterior uveal melanomas in one eye. Arch Ophthalmol. 1988;10622-10623. https://doi.org/10.1001/archopht.1988.01060130024017
Lois N, Shields CL, Shields JA, De Potter P, Ramsey MS. Trifocal uveal melanoma. Am J Ophthalmol. 1997;124(6):848-850. https://doi.org/10.1016/s0002-9394(14)71708-8
Blumenthal EZ, Pe’er J. Multifocal choroidal malignant melanoma: at least 3 melanomas in one eye. Arch Ophthalmol. 1999;117255-117258. https://doi.org/10.1001/archopht.117.2.255
Dithmar S, Völcker HE, Grossniklaus HE. Multifocal intraocular malignant melanoma: report of two cases and review of the literature. Ophthalmology. 1999;106(7):1345-1348. https://doi.org/10.1016/s0161-6420(99)00722-8
Hammer ME, Margo CE. Unilateral multifocal uveal melanoma with occult ring melanoma. Arch Ophthalmol. 2002;120(8):1090-1091.
Dujmovic L, Ivekovic R, Bencic G, Vatavuk Z, Mandic Z. Different cell types in a unilateral multifocal intraocular melanoma. Klin Monbl Augenheilkd. 2013;230(7):678-679. https://doi.org/10.1055/s-0032-1328527
Neroev VV, Saakyan SV, Amiryan AG, Parmon YaV, Kruzhkova GV. Differential diagnostic criteria of uveal melanoma and choroidal metastases according to complex high frequency ultrasonography. Rossijskij Oftal’mologicheskij Zhurnal. 2015;8(2):5-13. (In Russ.)
Saakyan SV, Amiryan AG, Tsygankov AYu, Loginov VI, Burdennyy AM. Mutations in oncogenes GNAQ and GNA11 in uveal melanoma patients. Molekuljarnaja Medicina. 2014;2:34-37. (In Russ.)
Saakyan SV, Amiryan AG, Tsygankov AYu, Loginov VI, Burdennyy AM. Association of the ABCB1 gene with risk for uveal melanoma. Arhiv Patologii. 2014;76(2):3-7. (In Russ.)
Petousis V, Finger PT, Milman T. Multifocal iris melanoma treated with total anterior segment palladium-103 plaque radiation therapy. Graefes Arch Clin Exp Ophthalmol. 2011;249(6):937-940. https://doi.org/10.1007/s00417-010-1590-8
Zhang MM, Papakostas TD, Malcolm AW, Ancell KK, Biscotti CV, Gragoudas ES, Daniels AB. Multiple simultaneous choroidal melanomas arising in the same eye: globe salvage by radiotherapy. Acta Ophthalmol. 2016;94(8):799-802. https://doi.org/10.1111/aos.13034
Nissen EJ, Kalirai H, Damato B, Heimann H, Coupland SE. Two Distinct Uveal Melanomas in the Same Eye. JAMA Ophthalmol. 2015;133(9):1094-1096. https://doi.org/10.1001/jamaophthalmol.2015.1962