Influence of α2-adrenomimetics on incidence of choroidal effusion following laser trabeculoplasty in primary open angle glaucoma

Baranov I.Ia.

Sankt-Peterburgskiĭ filial FGBU MNTK "Mikrokhirurgiia glaza" im. akad. S.N. Fedorova

Shiryaev I.V.

Saint-Petersburg branch of the Academician S.N. Fyodorov IRTC «Eye Microsurgery», 21 Yaroslava Gasheka St., Saint-Petersburg, Russian Federation, 192283

Molodkina N.A.

Saint-Petersburg branch of the Academician S.N. Fyodorov IRTC «Eye Microsurgery», 21 Yaroslava Gasheka St., Saint-Petersburg, Russian Federation, 192283

Efimov O.A.

Saint Petersburg branch of S. Fyodorov Eye Microsurgery Federal State Institution, 21 Yaroslava Gasheka St., Saint Petersburg, Russian Federation, 192283

Mitrofanova N.V.

Sankt-Peterburgskiĭ filial FGBU MNTK "Mikrokhirurgiia glaza" im. akad. S.N. Fedorova

Influence of α2-adrenomimetics on incidence of choroidal effusion following laser trabeculoplasty in primary open angle glaucoma

Authors:

Baranov I.Ia., Shiryaev I.V., Molodkina N.A., Efimov O.A., Mitrofanova N.V.

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Journal: Russian Annals of Ophthalmology. 2018;134(5): 26‑31

DOI: 10.17116/oftalma201813405126

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To cite this article:

Baranov IIa, Shiryaev IV, Molodkina NA, Efimov OA, Mitrofanova NV. Influence of α2-adrenomimetics on incidence of choroidal effusion following laser trabeculoplasty in primary open angle glaucoma. Russian Annals of Ophthalmology. 2018;134(5):26‑31. (In Russ.)
https://doi.org/10.17116/oftalma201813405126

Подписка 2025 (Russian Annals of Ophthalmology)

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Purpose — to evaluate the influence of different topical hypotensive drugs on incidence of choroidal effusion (CE) following laser trabeculoplasty as the second stage of combined laser-surgical treatment plan in patients with primary open-angle glaucoma (POAG). Material and methods. The study included 60 patients with previously operated stage I and II POAG who has «b—c» intraocular pressure (IOP) on maximum hypotensive therapy. Fistulizing subscleral removal of the outer wall of Schlemm’s canal (a.k.a. subscleral sinusotomy) was the first stage of treatment plan. The second stage took place 14 days later in the form of laser trabeculoplasty. In order to reduce the risk of IOP spikes, all patients were prescribed specific hypotensive therapy 5 days prior to the procedure. The 1st group included 30 patients (30 eyes) who were asked to use Brimonidine-Purite (0.15%). The 2nd group included 30 patients (30 eyes) who used either nonselective β-blockers, or carbonic anhydrase inhibitors. IOP was measured on days 1, 5, 9, and 12 after stage 1, as well as after laser trabeculoplasty. Ophthalmic examination included ultrasound imaging and optical coherence tomography. Results. After the combined laser-surgical treatment, the IOP reliably decreased in both groups. Choroidal effusion was observed in 7 cases in the 1st group and in 15 cases in the 2nd group. Change in IOP was less prominent in patients who had received instillations of α2-adrenomimetic (p<0.05). Conclusion. Patients who received Brimonidine-Purite 0.15% before laser trabeculoplasty had lower IOP drop than those on pre-surgical therapy with nonselective β-blockers or carbonic anhydrase inhibitors. Topical application of 0.15% Brimonidine-Purite 5 days prior to laser trabeculoplasty as the second stage of combined laser-surgical treatment resulted in statistically significant reduction of the incidence of postoperative choroidal effusion, likely due to α2-adrenomimetics inhibiting the secretory function of the ciliary Body to the lesser extent than drugs of other groups that were tested.

Keywords:

primary open-angle glaucoma

hypotensive topical therapy

α2-adrenomimetics

subscleral sinusotomy

laser trabeculoplasty

choroidal effusion

Authors:

Baranov I.Ia.

Sankt-Peterburgskiĭ filial FGBU MNTK "Mikrokhirurgiia glaza" im. akad. S.N. Fedorova

Shiryaev I.V.

Saint-Petersburg branch of the Academician S.N. Fyodorov IRTC «Eye Microsurgery», 21 Yaroslava Gasheka St., Saint-Petersburg, Russian Federation, 192283

Molodkina N.A.

Saint-Petersburg branch of the Academician S.N. Fyodorov IRTC «Eye Microsurgery», 21 Yaroslava Gasheka St., Saint-Petersburg, Russian Federation, 192283

Efimov O.A.

Saint Petersburg branch of S. Fyodorov Eye Microsurgery Federal State Institution, 21 Yaroslava Gasheka St., Saint Petersburg, Russian Federation, 192283

Mitrofanova N.V.

Sankt-Peterburgskiĭ filial FGBU MNTK "Mikrokhirurgiia glaza" im. akad. S.N. Fedorova

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