Fuchs endothelial corneal dystrophy

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Fuchs endothelial dystrophy is a severe disease characterized by slowly progressing bilateral asymmetric corneal edema usually seen in elderly patients. The primary purpose of treatment is to minimize edema-related symptoms, such as ocular discomfort and visual acuity loss. Conservative therapy is symptomatic and has a short-term positive effect that does not lead to full functional rehabilitation of the patient, while endothelial keratoplasty is pathogenetically oriented. Intentional replacement of pathologically altered corneal layers has several advantages: preservation of corneal architectonics, rapid recovery of visual function, ‘closed eye’ surgery with corneal tunnel approach, and independence from expensive equipment. However, principle indications and contraindications for various modifications of endothelial keratoplasty in the presence of comorbidity are still to be defined. Further improvement of the methods and their broader implementation into clinical practice are the most pressing and promising issues of corneal transplantation.

Keywords:

cornea

dystrophy

cornea guttata

endothelium

endothelial keratoplasty

DSEK

DSAEK

FS-DSEK

DMEK

Authors:

Trufanov S.V.

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ RAMN", Moskva

SPIN RSCI: 1603-8931
Scopus AuthorID: 6508163770
ORCID: 0000-0003-4360-793X

Salovarova E.P.

Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021

Malozhen S.A.

Uchrezhdenie Rossiĭskoĭ akademii meditsinskikh nauk "NII glaznykh bolezneĭ" RAMN, Moskva

Bagh R.Z.

Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021

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