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Avetisov S.É.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Chernenkova N.A.

Research Institute of Eye Diseases, 11A, B Rossolimo St., Moscow, Russian Federation, 119021

Surnina Z.V.

FGBU "NII glaznykh bolezneĭ" RAMN

Clinical features and diagnosis of diabetic polyneuropathy

Authors:

Avetisov S.É., Chernenkova N.A., Surnina Z.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2017;133(5): 98‑102

DOI: 10.17116/oftalma2017133598-102

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To cite this article:

Avetisov SÉ, Chernenkova NA, Surnina ZV. Clinical features and diagnosis of diabetic polyneuropathy. Russian Annals of Ophthalmology. 2017;133(5):98‑102. (In Russ.)
https://doi.org/10.17116/oftalma2017133598-102

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Diabetic polyneuropathy (DPN) is a serious complication of diabetes that leads to early disability in patients if late diagnosed. There has been a lot of research into pathophysiological mechanisms of nerve fiber damage and risk factors for neurological complications of diabetes. Early diagnosis of the latter is quite a challenge and, thus, the problem of finding more reliable diagnostic modalities is rather pressing. In this review, an interdisciplinary approach to the said problem, high-end diagnostic methods, and clinical features of DPN are described.

Keywords:

diabetic polyneuropathy
peripheral nerves
corneal nerve fibers
confocal laser scanning microscopy

Authors:

Avetisov S.É.

FGBU "Nauchno-issledovatel'skiĭ institut glaznykh bolezneĭ" RAMN, Moskva

Chernenkova N.A.

Research Institute of Eye Diseases, 11A, B Rossolimo St., Moscow, Russian Federation, 119021

Surnina Z.V.

FGBU "NII glaznykh bolezneĭ" RAMN

List of references:

  1. International Diabetes Federation. IDF Diabetes Atlas. 6th ed. Brussels, Belgium: International Diabetes Federation. 2013.
  2. Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy: technical review. Diabetes Care. 2003;26(5):1553-1579. https://doi.org/10.2337/diacare.26.5.1553
  3. Abe H, Hoshi M. A statistical analysis of the neurological manifestations of Japanese diabetic patients. Diabetic Microangiopathy. 1983;3:143-152. https://doi.org/10.1159/000409018
  4. Pirart Jю Diabetes mellitus and its degenerative complications: a prospective study of 4400 patients observed between 1947 and 1973. Diabetes Care. 1978;1(3):168-188. https://doi.org/10.2337/diacare.1.3.168
  5. The prevalence of foot ulceration and its correlates in type 2 diabetic patients: a population-based studyю S Kumar, H A Ashe, L Parnell et al. Diabetic Medicine. 1994;11(5):480-484. https://doi.org/10.1111/j.1464-5491.1994.tb00310.x
  6. Boulton AJM, VinikAL, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005;28(4):956-996.
  7. Tesfaye S, Boulton AJ, Dickenson AH. Mechanisms and management of diabetic painful distal symmetrical polyneuropathy. Diabetes Care. 2013;36(9):2456-2465. https://doi.org/10.2337/dc12-1964
  8. Tesfaye S, Stevens LK, Stephenson JM, Fuller JH, Plater M, Ionescu-Tirgoviste C, Nuber A, Pozza G, Ward JD. Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors:the EURODIAB IDDM Complications Study. Diabetologia. 1996;39(11):1377-1384. https://doi.org/10.1007/s001250050586
  9. Abbott CA, Malik RA, van Ross ER, Kulkarni J, Boulton AJ. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Diabetes Care. 2011;34(10):2220-2224. https://doi.org/10.2337/dc11-1108
  10. Ziegler D, Rathmann W, Dickhaus T, Meisinger C, Mielck A. KORA Study Group. Neuropathic pain in diabetes, prediabetes and normal glucose tolerance:the MONICA/KORA Augsburg Surveys S2 and S3. Pain Medicine. 2009;10(2):393-400. https://doi.org/10.1111/j.1526-4637.2008.00555.x
  11. Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Heller GV, Iskandrian AE, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE. DIAD Investigators. Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes:the DIAD study:a randomized controlled trial. JAMA. 2009;301(15):1547. https://doi.org/10.1001/jama.2009.476
  12. Ziegler D Rathmann W, Dickhaus T, Meisinger C, Mielck A. Prevalence of Polyneuropathy in Prediabetes and Diabetes is Associated with Abdominal Obesity and Macroangiopathy. The MONICA/KORA Augsburg Surveys S2 and S3. Diabetes Care. 2007;31(3):464-469. https://doi.org/10.2337/dc07-1796
  13. Albers JW, Pop-Busui R. Diabetic neuropathy:mechanisms, emerging treatments, and subtypes. Curr Neurol Neurosci Rep. 2014;14(8):473. https://doi.org/10.1007/s11910-014-0473-5
  14. The Diabetes Control and Complications Trial Research Group. The effect of intensive diabetes therapy on the development and progression of neuropathy. Ann Intern Med. 1995;122(8):561-568. https://doi.org/10.7326/0003-4819-122-8-199504150-00001
  15. Herman WH, Aubert RE, EngelgauMMet al. Diabetes mellitus in Egypt: glycaemic control and microvascular and neuropathic complications. Diabet Med. 1998;15(12):1045-1051.
  16. Cabezas-Cerrato J. The prevalence of clinical diabetic polyneuropathy in Spain: a study in primary care and hospital clinic groups. Diabetologia. 1998;41(11):1263-1269. https://doi.org/10.1007/s001250051063
  17. Young MJ, Boulton AJM, Macleod AF et al. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia. 1993;36(2):150-154. https://doi.org/10.1007/bf00400697
  18. Partanen J, Niskanen L, Lehtinen J et al. Natural history of peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus. N Engl J Med. 1995;333(2):89-94. https://doi.org/10.1056/nejm199507133330203
  19. Haffner SM, Lehto S, Ronnemaa T et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998;339:229-234. https://doi.org/10.1056/nejm199807233390404
  20. Forrest KY, Maser RE, Pambianco G, Becker DJ, Orchard TJ. Hypertension as a risk factor for diabetic neuropathy: a prospective study. Diabetes. 1997;46(4):665-670. https://doi.org/10.2337/diabetes.46.4.665
  21. Adler AI, Boyko EJ, Ahroni JH, Stensel V, Forsberg RC, Smith DG. Risk factors for diabetic peripheral sensory neuropathy. Results of the Seattle Prospective Diabetic Foot Study. Diabetes Care. 1997;20(7):1162-1167. https://doi.org/10.2337/diacare.20.7.1162
  22. Harris M, Eastman R, Cowie C. Symptoms of sensory neuropathy in adults with NIDDM in the U.S. population. Diabetes Care. 1993;16(11):1446-52. https://doi.org/10.2337/diacare.16.11.1446
  23. Cameron NA, Eaton SE, Cotter MA, Tesfaye S. Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia. 2001;44(11):1973-1988. https://doi.org/10.1007/s001250100001
  24. Malik RA, Tesfaye S, Thompson SD, et al. Endoneurial localisation of microvasculardamage in human diabetic neuropathy. Diabetologia. 1993;36(5):454-459. https://doi.org/10.1007/bf00402283
  25. Newrick PG, Wilson AJ, Jakubowski J, Boulton AJ, Ward JD. Sural nerve oxygentension in diabetes. Br Med J (J Clin ResEd). 1986;293(6554):1053-1054. https://doi.org/10.1136/bmj.293.6554.1053
  26. Tesfaye S, Harris N, Jakubowski JJ, et al. Impaired blood flow and arterio-venous shunting in human diabetic neuropathy: a novel technique of nerve photography and fluoroscein angiography. Diabetologia. 1993;36(12):1266-1274. https://doi.org/10.1007/bf00400804
  27. Bromberg MB. Peripheral neurotoxic disorders. Neurol Clin. 2000;18(3):681-694. https://doi.org/10.1016/s0733-8619(05)70218-8
  28. Sugimoto K, Murakawa Y, Sima AA. Diabetic neuropathy — a continuing enigma. Diabetes Metab Res Rev. 2000;16(6):408-433.
  29. Vinik AI, Park TS, Stansberry KB, Pittenger GL. Diabetic neuropathies. Diabetologia. 2000;43(8):957-973. https://doi.org/10.1007/s001250051477
  30. Zochodne D. Diabetic polyneuropathy:an update. Curr Opin Neurol. 2008;21(5):527-533. https://doi.org/10.1097/wco.0b013e32830b84cb
  31. Russel JW, Sullivan KA, Windebank AJ, Hermann DN, Feldmann EL. Neurons undergo apoptosis in animal andmcell culture models of diabetes. Neurobiol. Dis.1999;6:347-363. https://doi.org/10.1006/nbdi.1999.0254
  32. Russel JW et al. High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB. 2002;16:1738-1748. https://doi.org/10.1096/fj.01-1027com
  33. Schmeichel AM, Schmelzer JD, and Low PA. Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes. 2003;52:165-171. https://doi.org/10.2337/diabetes.52.1.165
  34. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;424(6865):813-820. https://doi.org/10.1038/414813a
  35. Ryle C, Donaghy M. Non-enzymatic glycation of peripheral nerve proteins in human diabetics. J Neurol Sci. 1995;129(1):62-68. https://doi.org/10.1016/0022-510x(94)00251-i
  36. Tavee J, Zhov L. Small fiber neuropathy:A burning problem. Cleveland Clinic Journal of Medicine. 2009;76(5):297-305. https://doi.org/10.3949/ccjm.76a.08070
  37. Herman WH, Kennedy L. Underdiagnosis of peripheral neuropathy in type 2 diabetes. Diabetes Care. 2005;28(6):1480-1481. https://doi.org/10.2337/diacare.28.6.1480
  38. American Diabetes Association and American Academy of Neurology. Report and recommendations of the San Antonio conference on diabetic neuropathy (Consensus Statement). Diabetes Care. 1988;11(7):592-597. https://doi.org/10.2337/diacare.11.7.592
  39. Feng Y1, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy. J Vasc Surg. 2011;53(1):220-226.e5 https://doi.org/10.1016/j.jvs.2010.06.100
  40. Paisley AN, Abbott CA, Van Schie CHMand Boulton AJM. A comparison of the Neuropen against standard quantitative sensory-threshold measures for assessing peripheral nerve function. Diabet Med. 2002;19:400-405. https://doi.org/10.1046/j.1464-5491.2002.00706.x
  41. Casellini CM, Vinik AI. Clinical Manifestations and Current Treatment Options for Diabetic Neuropathies. Endocr Pract. 2007;13(5):550-566. https://doi.org/10.4158/ep.13.5.550
  42. Ziegler D. Diagnosis and management of diabetic peripheal neuropathy. Diabet Med. 1996;13(1):S34-38.
  43. Rolke R, Magerl W, Andrews Campbell K, Schalber C, Caspari S, Birklein F, Treede RD. Quantitative sensory testing:a comprehensive protocol for clinical trials. Eur J Pain. 2006;10:77-88. https://doi.org/10.1016/j.ejpain.2005.02.003
  44. Said G. Diabetic Neuropathy. Nat Clin Pract Neurol. 2007;3(6):331-340. https://doi.org/10.1038/ncpneuro0504
  45. Vinik AI, Mehrabyan A. Diabetic Neuropathies. Med Clin North Am. 2004;88(4):947-999. https://doi.org/10.1016/j.mcna.2004.04.009
  46. Boulton AJ, Malik RA, Arezzo JC, Sosenko JM. Diabetic somatic neuropathies. Diabetes Care. 2004;27:1458-1486. https://doi.org/10.2337/diacare.27.6.1458
  47. Boulton AJ, Vinik AI, Arezzo JC Diabetic Neuropathies:a statement by the American Diabetes Association. Diabetes Care. 2005;28(4):956-962. https://doi.org/10.2337/diacare.28.4.956
  48. Caselli A. Validation of the nerve axon reflex for the assessment of small nerve fibre dysfunction. J Neurol Neurosurg Psychiatry. 2006;77(8):927-932. https://doi.org/10.1136/jnnp.2005.069609
  49. Bril V. Role of Electrophysiological Studies in Diabetic Neuropathy. Can J of Neurol Sciences. 1994;21(S4):S8-S12. https://doi.org/10.1017/s0317167100040683
  50. Abraham RR, Abraham RM, Wynn V. Autonomic and electrophysiological studies studies in patients with signs or symptoms of diabetic neuropathy. Electroencephal. Clin. Neurophysiol. 1986;63(3):223-230. https://doi.org/10.1016/0013-4694(86)90088-x
  51. Ward JD, Fisher DJ, Barnes CG et al. Improvement in nerve conduction following treatment in newly diagnosed diabetics. Lancet. 1971;1:428-431. https://doi.org/10.1016/s0140-6736(71)92415-9
  52. Müller L, Pels L, de Wolf A, Vrensen G, Kliffen M. Ultrastructure of human corneal nerves. Vision Research. 1995;35:S135. https://doi.org/10.1016/0042-6989(95)90300-3
  53. Tavakoli M, Hossain P, Malik R. Clinical applications of corneal confocal microscopy. Clinical Ophtalmology. 2008;2(2):435-445. https://doi.org/10.2147/opth.s1490
  54. Uenda S, Del Cerro M, James V Aquavella. The Innervation in the Human Cornea. A Correlative Light and Electron Microscopic Study. The Cornea. 1987;6(1):75. https://doi.org/10.1097/00003226-198706010-00093
  55. Rosenberg Maria E, Tervo Timi MT, Immonen IJ, Müller LJ, Grönhagen—Riska C, Vesaluoma Minna H. Corneal structure and sensitivity in type 1 diabetes mellitus. Am J Ophthalmol. 2000;130(6):865. https://doi.org/10.1016/s0002-9394(00)00839-4
  56. Hosotani H, Ohashi Y, Yamada M, Tsubota K. Reversal of abnormal corneal epithelial cell morphologic characteristics and reduced corneal sensitivity in diabetic patients by aldose reductase inhibitor. Am J Ophthalmol. 1995;119:288-294. https://doi.org/10.1016/s0002-9394(14)71169-9
  57. Avetisov SE, Novikov IA, Makhotin SS, Surnina ZV. New approach to corneal nerve fibers morphometry in diabetes mellitus on the basis of confocal biomicroscopy. Vestnik oftal’mologii. 2015;131(4):5-11. (In Russ.)
  58. Avetisov SE, Novikov IA, Makhotin SS, Surnina ZV. Calculation of Anisotropy and Symmetry Coefficients of Corneal Nerve Orientation Based on Automated Recognition of Digital Confocal Images. Meditsinskaya tekhnika. 2015;49(3):23-25. (In Russ.)
  59. Ahmed A, Bril V,Orszag A, et al. Detection of diabetic sensorimotor polyneuropathy by corneal confocal microscopy in type 1 diabetes:a concurrent validity study. Diabetes Care. 2012;35:821-828. https://doi.org/10.2337/dc11-1396
  60. Perkins BA, Ngo M, Bril V. Symmetry of nerve conduction studies in different stages of diabetic polyneuropathy. Muscle Nerve. 2002;25:212-217. https://doi.org/https://doi.org/ 10.1002/mus.10044.abs
  61. Petropoulos IN, Alam U, Fadavi H, et al. Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. Diabetes Care. 2013;36:3646-3651. https://doi.org/10.2337/dc13-0193

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