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Boĭko É.V.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Churashov S.V.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Kamilova T.A.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Molecular genetic basis of age-related macular degeneration

Authors:

Boĭko É.V., Churashov S.V., Kamilova T.A.

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Journal: Russian Annals of Ophthalmology. 2013;129(2): 81‑85

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MOLECULAR GENETIC BASIS OF AGE-RELATED MACULAR DEGENERATION
MOLECULAR GENETIC BASIS OF AGE-RELATED MACULAR DEGENERATION

To cite this article:

Boĭko ÉV, Churashov SV, Kamilova TA. Molecular genetic basis of age-related macular degeneration. Russian Annals of Ophthalmology. 2013;129(2):81‑85. (In Russ.)

Подписка 2025-2 (Russian Annals of Ophthalmology)
 
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Visual loss due to age-related macular degeneration (AMD) is caused by one or both forms of advanced disease: "wet" (neovascular) or "dry" (geographic atrophy). Immune system plays a central role in pathogenesis and progression of both AMD forms. Main genetic polymorphisms associated with risk of AMD development and progression were found to be genes that regulate inflammation especially in complement factor H gen (1q31 locus) and 10q26 locus (PLEKHA1/ARMS2/HTRA1). Association of response to treatment and genotype was shown in patients with AMD. Complete characterization of both common and rare alleles that influence AMD risk is necessary for accurate determination of individual genetic risk as well as identification of new targets for therapeutic intervention.

Keywords:

age-related macular degeneration
polymorphism
chronic inflammation
complement
extracellular matrix

Authors:

Boĭko É.V.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Churashov S.V.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Kamilova T.A.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

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