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Yurova V.A.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Bobrova L.A.

Kafedra nefrologii i gemodializa instituta professional'nogo obrazovaniia GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Minzdrava Rossii

Kozlovskaya N.L.

Department of Nephrology and Hemodialysis, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia;
Research Department of Nephrology, Research Center, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Korotchaeva Yu.V.

Department of Nephrology and Hemodialysis, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia;
Research Department of Nephrology, Research Center, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Serova A.G.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Kozlov L.V.

FGUN "Moskovskiĭ NII pidemiologii i mikrobiologii im. G.N. Gabrichevskogo" Rospotrebnadzora Rossii

Andina S.S.

G.N.Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow, Russia

Dem'ianova K.A.

Kafedra nefrologii i gemodializa instituta professional'nogo obrazovaniia GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Minzdrava Rossii

Kuchieva A.M.

I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Roshchupkina S.V.

UKB #3, Klinika nefrologii, vnutrennikh i professional'nykh bolezneĭ im. E.M. Tareeva GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Minzdrava Rossii

Changes in the complement system in membranoproliferative glomerulonephritis

Authors:

Yurova V.A., Bobrova L.A., Kozlovskaya N.L., Korotchaeva Yu.V., Serova A.G., Kozlov L.V., Andina S.S., Dem'ianova K.A., Kuchieva A.M., Roshchupkina S.V.

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Journal: Therapeutic Archive. 2017;89(6): 69‑77

DOI: 10.17116/terarkh201789669-77

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Table of contents

CHANGES IN THE COMPLEMENT SYSTEM IN MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
CHANGES IN THE COMPLEMENT SYSTEM IN MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS

To cite this article:

Yurova VA, Bobrova LA, Kozlovskaya NL, et al. . Changes in the complement system in membranoproliferative glomerulonephritis. Therapeutic Archive. 2017;89(6):69‑77. (In Russ.)
https://doi.org/10.17116/terarkh201789669-77

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Abstract:

Aim. To compare the clinical manifestations membranoproliferative glomerulonephritis (MPGN) in its idiopathic variant, lupus nephritis (LN), and C3 glomerulopathy (C3-GP), by comparing them with changes in the complement system. Subjects and methods. The clinic of nephrology followed up 42 patients with different types of MPGN in 2013 to 2015. The study included 35 patients divided into 3 groups: 1) 8 patients with C3-GP, 2) 13 with idiopathic MPGN; 3) 14 with Class IV LN. The investigators studied the blood and urine levels of components and markers for activation of the classical and alternative pathways (C3 and C4, С3а, C5a, CFH, CFB, and CFD) of the terminal complement complex (TCC). Results. The detection rate of C3-GP was 19%. The patients with C3-GP were noted to have the lowest blood concentration of S3 and the highest urinary level of С3а, C5a, TCC, CFH, CFB, and CFD. C3 nephritic factor was detected in 2 patients from the C3-GP (dense deposit disease) group. Conclusion. Alternative complement pathway dysregulation caused by genetic or autoimmune factors plays a leading role in the pathogenesis of C3-GP.

Keywords:

membranoproliferative glomerulonephritis
C3 glomerulopathy
dense deposit disease
alternative complement pathway
complement dysregulation
C3 nephritic factor

Authors:

Yurova V.A.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Bobrova L.A.

Kafedra nefrologii i gemodializa instituta professional'nogo obrazovaniia GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Minzdrava Rossii

Kozlovskaya N.L.

Department of Nephrology and Hemodialysis, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia;
Research Department of Nephrology, Research Center, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Korotchaeva Yu.V.

Department of Nephrology and Hemodialysis, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia;
Research Department of Nephrology, Research Center, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Serova A.G.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Kozlov L.V.

FGUN "Moskovskiĭ NII pidemiologii i mikrobiologii im. G.N. Gabrichevskogo" Rospotrebnadzora Rossii

Andina S.S.

G.N.Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow, Russia

Dem'ianova K.A.

Kafedra nefrologii i gemodializa instituta professional'nogo obrazovaniia GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Minzdrava Rossii

Kuchieva A.M.

I.M. Sechenov First Moscow State Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991

Roshchupkina S.V.

UKB #3, Klinika nefrologii, vnutrennikh i professional'nykh bolezneĭ im. E.M. Tareeva GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova" Minzdrava Rossii

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References:

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